公开(公告)号：US4921654A

公开(公告)日：1990-05-01

申请号：US408737

申请日：1989-09-18

Applicant: Chung-Jen Hou ,  James Disbrow ,  Kenneth C. Hou

Inventor： Chung-Jen Hou ,  James Disbrow ,  Kenneth C. Hou

IPC: B01D67/00

CPC classification number: B01D67/0093 ,  B01D67/0011 ,  B01D2323/08 ,  B01D2323/12 ,  B01D2323/38 ,  B01D2323/385

Abstract: A modified microporous membrane comprising an organic polymeric microporous membrane having microporous surfaces and having hydroxyl, mercapto, carboxyl, or amino functionality on the surfaces modified by a reactive modifying polymer having a polymer chain and having along the polymer chain epoxy or epithio functional groups capable of reacting with the functionality on the surface of the membrane and terminal neutral chemical functionality. The preferred reactive modifying polymer is made from a free radical polymerization of:(a) a polymerizable compound containing an epoxy or epithio group capable of direct covalent coupling to the surface functionalities of the microporous membrane and a vinyl group capable of free radical polymerization; and(b) ##STR1## wherein R.sub.1 is an alpha, beta ethylenically unsaturated polymerizable radical of two or three carbon atoms;R.sub.2 is an alkyl substituent of two to five carbon atoms having a terminal hydroxyl functionality or (R.sub.3 O).sub.n H,wherein R.sub.3 is an alkyl substituent of two or three carbon atoms and n is 1 to 20.The membranes have a relatively low-binding capacity for protein.

Abstract translation: 一种改性微孔膜，其包含具有微孔表面并且具有羟基，巯基，羧基或氨基官能团的有机聚合物微孔膜，所述表面由具有聚合物链且具有聚合物链的反应性改性聚合物改性的表面具有环氧或环硫官能团 与膜表面的功能和末端中性化学官能团反应。 优选的反应性改性聚合物由以下的自由基聚合制成：（a）含有能够与微孔膜的表面官能团直接共价偶联的环氧基或环硫基的可聚合化合物和能够进行自由基聚合的乙烯基; 和（b）其中R1是两个或三个碳原子的α，β烯键式不饱和可聚合基团; R2是具有末端羟基官能度的二至五个碳原子的烷基取代基或（R3O）nH，其中R3是两个或三个碳原子的烷基取代基，n是1至20.该膜具有相对低的结合能力 用于蛋白质。