公开(公告)号：US4148787A

公开(公告)日：1979-04-10

申请号：US849389

申请日：1977-11-08

申请人： Jan L. Mulder, deceased ,  Lars A. I. Carlsson

发明人： Jan L. Mulder, deceased ,  Lars A. I. Carlsson

IPC分类号： A61K38/00 ,  C07K7/16 ,  C07C103/52 ,  A61K37/10 ,  C07G7/00

CPC分类号： C07K7/16 ,  A61K38/00 ,  Y10S514/807 ,  Y10S930/15

摘要： Antidiuretically effective vasopressin derivates of the formula ##STR1## in which Mep is a 2-mercaptopropionyl residue (--S--CH.sub.2 CH.sub.2 CO--), and A and B are glutamine (Gln) or asparagine (Asn) and A is Gln only when B is Gln and D-arginine is in position 8.A method for preparing the derivatives comprises the steps of gradually producing the amino acid sequenceMep(SH)--Tyr--Phe--A--B--Cys(SH)--Pro--D--Arg--Gly--NH.sub.2and thereafter oxidizing this amino acid sequence to the desired vasopressin derivative of the formula (I).

摘要翻译： Mep为2-巯基丙酰基残基（-S-CH 2 CH 2 CO-），A和B为谷氨酰胺（Gln）或天冬酰胺（Asn）的式为“IMAGE”的抗药用有效的加压素衍生物，只有当B为Gln时，A为Gln 而D-精氨酸处于8位。