公开(公告)号：US5407912A

公开(公告)日：1995-04-18

申请号：US50697

申请日：1993-04-19

申请人： Ray F. Ebert ,  Richard D. Swerdlow

发明人： Ray F. Ebert ,  Richard D. Swerdlow

IPC分类号： A61K38/00 ,  A61P35/00 ,  C07K14/435 ,  A61K37/10

CPC分类号： C07K14/435 ,  A61K38/00

摘要： The present invention is directed to a stabilized keyhole limpet hemocyanin (KLH) composition in which (i) its intact non-degraded subunit is approximately 400,000 in molecular weight based on SDS-PAGE analysis; and (ii) are contained at least about 50% didecameric or higher KLH multimers, based on sedimentation-equilibrium and/or sedimentation-velocity ultracentrifugation analyses. The KLH composition is stabilized at 4.degree. C. by dissolving and storing it in an isotonic buffer preferably containing calcium and magnesium. It is critical that the KLH not have been frozen or lyophilized during its preparation or storage. The KLH composition demonstrates enhanced immunogenic activity, particularly enhanced anti-tumor activity, which is reduced if the KLH is frozen or lyophilized. The KLH composition of the present invention exhibits enhanced anti-tumor activity in a murine bladder tumor model and thereby represents a new and useful anti-tumor immunotherapeutic agent.

摘要翻译： 本发明涉及稳定的匙孔血蓝蛋白（KLH）组合物，其中（i）基于SDS-PAGE分析，其完整的未降解亚基的分子量约为400,000; 和（ii）基于沉降 - 平衡和/或沉降速度超速离心分析，含有至少约50％的多孔或更高的KLH多聚体。 通过将KLH组合物溶解并储存在优选含有钙和镁的等渗缓冲液中，将其稳定在4℃。 在制备或储存期间，KLH不被冷冻或冻干是至关重要的。 KLH组合物表现出增强的免疫原性活性，特别是增强的抗肿瘤活性，如果KLH被冷冻或冻干，则其降低。 本发明的KLH组合物在鼠膀胱肿瘤模型中表现出增强的抗肿瘤活性，因此代表了新的和有用的抗肿瘤免疫治疗剂。

公开(公告)号：US5407454A

公开(公告)日：1995-04-18

申请号：US763100

申请日：1991-09-20

申请人： Anthony Cavalieri ,  Thomas Czapla ,  John Howard ,  Gururaj Rao

发明人： Anthony Cavalieri ,  Thomas Czapla ,  John Howard ,  Gururaj Rao

IPC分类号： A01H1/06 ,  C07K14/42 ,  C12N15/82 ,  A01H1/00 ,  C07K3/00 ,  A61K37/10 ,  A61K35/78

CPC分类号： C12N15/8286 ,  A01H1/06 ,  A01N65/00 ,  C07K14/42

摘要： Selected plant lectins have been found to be larvicidal against a number of common insect pests of agricultural crops. In a preferred embodiment, plant resistance to these insects is produced by inserting into the cells of a plant a gene whose expression causes production of one or more of these lectins in larvicidal amounts.

摘要翻译： 已经发现选定的植物凝集素对一些常见的农作物有害生物是杀幼虫的。 在一个优选的实施方案中，通过将表达导致产生一种或多种这些凝集素的基因以杀幼鼠的量插入到植物的细胞中来产生对这些昆虫的植物抗性。

公开(公告)号：US5304464A

公开(公告)日：1994-04-19

申请号：US777277

申请日：1991-11-27

申请人： Eva Akerlof ,  Ake Pousette

发明人： Eva Akerlof ,  Ake Pousette

IPC分类号： A61K38/00 ,  A61K35/16 ,  A61K38/16 ,  A61K39/395 ,  A61P13/02 ,  A61P15/00 ,  C07K1/16 ,  C07K1/22 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/52 ,  C07K14/76 ,  C07K14/765 ,  C07K14/775 ,  C07K16/00 ,  C07K16/06 ,  C07K16/18 ,  C07K16/24 ,  C07K16/42 ,  C07K19/00 ,  G01N33/577 ,  A01N1/02 ,  A61K37/10

CPC分类号： C07K16/42 ,  C07K14/4705 ,  C07K14/765 ,  C07K14/775 ,  C07K16/06 ,  C07K16/18 ,  A61K38/00

摘要： The present invention relates to a macromolecule of proteinaceous nature which activates sperm motility, a process for the preparation thereof by purification of the macromolecule from extracellular fluids, pharmaceutical preparations containing the macromolecule and antibodies directed against determinants specific to the macromolecule and the use thereof as a method to assay the potential fertility of sperm.

摘要翻译： PCT No.PCT / SE90 / 00213 Sec。 371日期1991年11月27日 102（e）日期1991年11月27日PCT 1990年4月2日PCT PCT。 出版物WO90 / 12032 1990年10月18日的日期。本发明涉及一种活化精子活力的蛋白质性质的大分子，其通过从细胞外液中纯化大分子而制备的方法，含有大分子的药物制剂和针对特异性的决定簇的抗体 大分子及其用途作为测定精子潜在生殖力的方法。

公开(公告)号：US4148787A

公开(公告)日：1979-04-10

申请号：US849389

申请日：1977-11-08

申请人： Jan L. Mulder, deceased ,  Lars A. I. Carlsson

发明人： Jan L. Mulder, deceased ,  Lars A. I. Carlsson

IPC分类号： A61K38/00 ,  C07K7/16 ,  C07C103/52 ,  A61K37/10 ,  C07G7/00

CPC分类号： C07K7/16 ,  A61K38/00 ,  Y10S514/807 ,  Y10S930/15

摘要： Antidiuretically effective vasopressin derivates of the formula ##STR1## in which Mep is a 2-mercaptopropionyl residue (--S--CH.sub.2 CH.sub.2 CO--), and A and B are glutamine (Gln) or asparagine (Asn) and A is Gln only when B is Gln and D-arginine is in position 8.A method for preparing the derivatives comprises the steps of gradually producing the amino acid sequenceMep(SH)--Tyr--Phe--A--B--Cys(SH)--Pro--D--Arg--Gly--NH.sub.2and thereafter oxidizing this amino acid sequence to the desired vasopressin derivative of the formula (I).

摘要翻译： Mep为2-巯基丙酰基残基（-S-CH 2 CH 2 CO-），A和B为谷氨酰胺（Gln）或天冬酰胺（Asn）的式为“IMAGE”的抗药用有效的加压素衍生物，只有当B为Gln时，A为Gln 而D-精氨酸处于8位。

公开(公告)号：US5932619A

公开(公告)日：1999-08-03

申请号：US965935

申请日：1997-11-07

申请人： Lourens Jan Dirk Zaneveld ,  Robert Anthony Anderson, Jr. ,  Xiao Hui Diao ,  Paul Robert Young, Jr. ,  Donald Paul Waller ,  Sanjay Garg ,  Calvin J. Chany, II ,  Darrick S. H. L. Kim

发明人： Lourens Jan Dirk Zaneveld ,  Robert Anthony Anderson, Jr. ,  Xiao Hui Diao ,  Paul Robert Young, Jr. ,  Donald Paul Waller ,  Sanjay Garg ,  Calvin J. Chany, II ,  Darrick S. H. L. Kim

IPC分类号： A61K31/192 ,  A61K31/70 ,  A61K31/775 ,  A61K37/10

CPC分类号： A61K31/192 ,  A61K31/70 ,  A61K31/775

摘要： A method for the reduction in the risk of transmitting a sexually transmitted disease--especially HIV and/or HSV--during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably as a topical formulation, to the area or areas of sexual contact prior to engaging in sexual activity. Inhibitory agents which are useful in the present invention include, for example, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H.sub.2 SO.sub.4 -modified mandelic acids, and the like. This method can be used by heterosexuals, homosexuals, and/or bisexuals engaged in a wide variety of sexual activities. In addition to anti-STD activity, these agents may also act as vaginal contraceptives; moreover, they generally have fewer side effects than conventional vaginal contraceptives (e.g., nonoxynol-9). For example, the compounds useful in this invention are generally not toxic to natural and beneficial vaginal flora and, thus, do not upset the local microbiological balance. The anti-STD method of the present invention has the added advantage that it can be implemented and controlled by either sexual party. Methods are also provided for reducing the risk of transmission of STD-causing organisms to health care providers and laboratory personnel (or other persons) who may come into contact with biological samples and specimens.

公开(公告)号：US5376632A

公开(公告)日：1994-12-27

申请号：US906780

申请日：1992-06-30

申请人： Frank J. Konings ,  Marcus J. M. Noppe ,  Jean L. Mesens

发明人： Frank J. Konings ,  Marcus J. M. Noppe ,  Jean L. Mesens

IPC分类号： A61K38/22 ,  A61K38/18 ,  A61K47/40 ,  A61K47/48 ,  A61P7/00 ,  A61K37/10 ,  C08B37/16

CPC分类号： B82Y5/00 ,  A61K38/1816 ,  A61K47/48969 ,  Y10S514/814

摘要： The present invention relates to a new pharmaceutical composition for parenteral and local administration comprising an aqueous solution of erythropoietin and a .beta.- or .gamma.-cyclodextrin hydroxyalkyl derivative. The invention also relates to novel lyophilized or spray-dried erythropoietin compositions comprising a .beta.- or .gamma.-cyclodextrin hydroxyalkyl derivative, to processes for preparing such aqueous, lyophilized or spray-dried compositions and to a method for simultaneously stabilizing erythropoietin in an aqueous solution and preventing it from being adsorbed to surfaces.

摘要翻译： 本发明涉及用于胃肠外和局部给药的新型药物组合物，其包含促红细胞生成素的水溶液和β-或γ-环糊精羟烷基衍生物。 本发明还涉及包含β-或γ-环糊精羟烷基衍生物的新型冻干或喷雾干燥的促红细胞生成素组合物，用于制备这种水性，冻干或喷雾干燥的组合物的方法以及在水溶液中同时稳定促红细胞生成素的方法， 防止其吸附在表面上。

公开(公告)号：US5340579A

公开(公告)日：1994-08-23

申请号：US541119

申请日：1990-06-20

申请人： Riccardo Casero, deceased

发明人： Riccardo Casero, deceased

IPC分类号： A61K8/73 ,  A61K8/98 ,  A61Q7/00 ,  A61K35/00 ,  A61K37/00 ,  A61K37/02 ,  A61K37/10

CPC分类号： A61K8/735 ,  A61K8/982 ,  A61Q7/00 ,  Y10S514/844 ,  Y10S514/847 ,  Y10S514/858 ,  Y10S514/859 ,  Y10S514/86 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/863 ,  Y10S514/864 ,  Y10S514/865

摘要： A method is provided for treating dermatological conditions by binding and blocking 5-a-dihydrotestosterone receptors comprising applying to the skin an effective amount of composition comprising:(a) from about 0.1% to about 2.0% by weight of mucopolysaccharides free of proteins and having a pH ranging from about 5 to 7.5 in aqueous solution, a rotary power between about to +15, and a sulfur content greater than 6%;(b) from about 1% to about 3% by weight of an aqueous extract of human umbilical cord free from sulfur and having a DH of from about 5 to about 7, a viscosity of 30.degree. C. of from 10 to 25 centistokes, a hyaluronic acid titre of from about 500 to about 700 mg/dl, and an ash content of less than about 0.5%;(c) from about 0.05 to about 0.08% by weight of tetrahydrofurfuryl nicotinate; and(d) pharmaceutically and cosmetically acceptable vehicles and excipients.This method is particularly useful in treating dermatological conditions such as acne, wrinkles, lipodiystrophies, dermosclorosis, androgenic alopecia, hypertrichosis, and the like.

摘要翻译： 提供了通过结合和阻断5-α-二氢睾酮受体来治疗皮肤病学病症的方法，包括向皮肤施用有效量的组合物，其包含：（a）约0.1％至约2.0％重量的不含蛋白质的粘多糖， 在水溶液中约5至7.5的pH，约+15之间的旋转动力和大于6％的硫含量; （b）约1％至约3％重量的不含硫的人脐带水提取物，其DH为约5至约7，粘度为30至10厘沲， 约500至约700mg / dl的透明质酸滴度和小于约0.5％的灰分含量; （c）约0.05至约0.08重量％的四氢糠基烟酸酯; 和（d）药学上和化妆品上可接受的载体和赋形剂。 该方法特别可用于治疗皮肤病，如痤疮，皱纹，脂肪营养不良，皮肤病，雄激素性脱发，肥大症等。

公开(公告)号：US5290576A

公开(公告)日：1994-03-01

申请号：US810010

申请日：1991-12-20

申请人： Djurdjica Ljevakovic ,  Branka Vranesic ,  Jelka Tomasic ,  Ivo Hrsak ,  Branko Ladesic

发明人： Djurdjica Ljevakovic ,  Branka Vranesic ,  Jelka Tomasic ,  Ivo Hrsak ,  Branko Ladesic

IPC分类号： A61K38/00 ,  A61K51/00 ,  A61K51/08 ,  A61P35/00 ,  A61P37/04 ,  C07K1/02 ,  C07K1/06 ,  C07K1/113 ,  C07K1/14 ,  C07K9/00 ,  A61K37/10 ,  C07H15/00 ,  C07H17/00

CPC分类号： A61K51/088 ,  C07K9/005 ,  A61K2121/00

摘要： The present invention relates to the novel tert-butyloxycarbonyl-L-tyrosylpeptidoglycan monomer ##STR1## and to its .sup.125 I-labelled Boc-Tyr-PGM derivative; to the preparation and use thereof as pharmaceuticals of immunostimulating and antitumor activity.

摘要翻译： 本发明涉及新的叔丁氧基羰基-L-酪氨酰肽聚单体（*化学结构*）I（*化学结构*）及其125 I标记的Boc-Tyr-PGM衍生物; 作为免疫刺激和抗肿瘤活性的药物的制备和使用。

公开(公告)号：US5284829A

公开(公告)日：1994-02-08

申请号：US798565

申请日：1991-11-26

申请人： James H. McKerrow ,  Fred E. Cohen

发明人： James H. McKerrow ,  Fred E. Cohen

IPC分类号： A61K38/00 ,  A61K38/55 ,  C07K5/08 ,  A61K37/10 ,  A61K37/02

CPC分类号： A61K38/55 ,  C07K5/0827 ,  Y10S514/846 ,  Y10S514/969

摘要： The invention relates to synthetic tetrapeptides that contain a peptide blocking group at the amino terminus and an enzyme inhibitor at the carboxy terminus, and their use in the prevention of schistosome parasite infection.

摘要翻译： 本发明涉及在氨基末端含有肽封闭基团和羧基末端的酶抑制剂的合成四肽及其在预防血吸虫寄生虫感染中的用途。

公开(公告)号：US4751218A

公开(公告)日：1988-06-14

申请号：US804687

申请日：1985-12-04

申请人： Pierre Smets ,  Rene Zalisz

发明人： Pierre Smets ,  Rene Zalisz

IPC分类号： A61K31/715 ,  A61K35/74 ,  A61P37/00 ,  A61P37/08 ,  C08B37/00 ,  C12P19/04 ,  C12P19/26 ,  C12P21/00 ,  A61K31/70 ,  A61K37/10

CPC分类号： C08B37/00 ,  A61K31/715 ,  C12P19/04 ,  C12P19/26 ,  C12P21/005 ,  Y10S514/885

摘要： An acylglycan extract of Klebsiella consisting essentially of about 80% of neutral oses, about 20% of lipids and less than 2% of proteins and having a molecular weight of approximately 12,500 and a process for obtining them which have antiallergic and immunomodulating properties.

摘要翻译： 克雷伯菌的酰基甘氨酸提取物基本上由约80％的中性油，约20％的脂质和小于2％的蛋白质组成，分子量约为12,500，以及一种具有抗过敏和免疫调节特性的方法。