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1.发明申请INDENTIFICATION OF COMPOUNDS THAT INHIBIT REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS 审中-公开抑制人类免疫缺陷病毒复制化合物的鉴定公开(公告)号：US20090170953A1
公开(公告)日：2009-07-02
申请号：US11929695
申请日：2007-10-30
IPC分类号： A61K31/164 , C12N7/04 , A61P31/18
CPC分类号： C07C237/06 , A61K31/164 , B01D15/34 , B01D15/362
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
摘要翻译： 本发明涉及发现抑制人类免疫缺陷病毒（HIV）复制的新一类化合物以及鉴定这些化合物的方法。 更具体地，已经发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺抑制人血清中HIV的复制。 实施方案包括鉴定修饰的抑制HIV的甘氨酰胺化合物的方法，分离和合成修饰的甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
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2.发明申请Identification of compounds that inhibit replication of human immunodeficiency virus 审中-公开鉴定抑制人类免疫缺陷病毒复制的化合物公开(公告)号：US20060188920A1
公开(公告)日：2006-08-24
申请号：US11409671
申请日：2006-04-24
CPC分类号： C07C237/06 , A61K31/164 , B01D15/34 , B01D15/362
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
摘要翻译： 本发明涉及发现抑制人类免疫缺陷病毒（HIV）复制的新一类化合物以及鉴定这些化合物的方法。 更具体地，已经发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺抑制人血清中HIV的复制。 实施方案包括鉴定修饰的抑制HIV的甘氨酰胺化合物的方法，分离和合成修饰的甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
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公开(公告)号：US20060183748A1
公开(公告)日：2006-08-17
申请号：US11410633
申请日：2006-04-25
IPC分类号： A61K31/513 , A61K31/4965 , A61K31/495
CPC分类号： A61K31/164 , A61K31/495 , A61K31/4965 , A61K31/513 , A61K31/53 , C07C237/06
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
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