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1.发明申请Identification of compounds that inhibit replication of human immunodeficiency virus 审中-公开鉴定抑制人类免疫缺陷病毒复制的化合物公开(公告)号：US20060188920A1
公开(公告)日：2006-08-24
申请号：US11409671
申请日：2006-04-24
CPC分类号： C07C237/06 , A61K31/164 , B01D15/34 , B01D15/362
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
摘要翻译： 本发明涉及发现抑制人类免疫缺陷病毒（HIV）复制的新一类化合物以及鉴定这些化合物的方法。 更具体地，已经发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺抑制人血清中HIV的复制。 实施方案包括鉴定修饰的抑制HIV的甘氨酰胺化合物的方法，分离和合成修饰的甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
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2.发明申请INDENTIFICATION OF COMPOUNDS THAT INHIBIT REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS 审中-公开抑制人类免疫缺陷病毒复制化合物的鉴定公开(公告)号：US20090170953A1
公开(公告)日：2009-07-02
申请号：US11929695
申请日：2007-10-30
IPC分类号： A61K31/164 , C12N7/04 , A61P31/18
CPC分类号： C07C237/06 , A61K31/164 , B01D15/34 , B01D15/362
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
摘要翻译： 本发明涉及发现抑制人类免疫缺陷病毒（HIV）复制的新一类化合物以及鉴定这些化合物的方法。 更具体地，已经发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺抑制人血清中HIV的复制。 实施方案包括鉴定修饰的抑制HIV的甘氨酰胺化合物的方法，分离和合成修饰的甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
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公开(公告)号：US20060183748A1
公开(公告)日：2006-08-17
申请号：US11410633
申请日：2006-04-25
IPC分类号： A61K31/513 , A61K31/4965 , A61K31/495
CPC分类号： A61K31/164 , A61K31/495 , A61K31/4965 , A61K31/513 , A61K31/53 , C07C237/06
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
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4.发明申请Identification of compounds that inhibit replication of human immunodeficiency virus 审中-公开鉴定抑制人类免疫缺陷病毒复制的化合物公开(公告)号：US20050096319A1
公开(公告)日：2005-05-05
申请号：US10920831
申请日：2004-08-18
申请人： Jan Balzarini , Anders Vahlne , Marita Hogberg , Weimin Tong
发明人： Jan Balzarini , Anders Vahlne , Marita Hogberg , Weimin Tong
IPC分类号： A61K31/164 , C07C237/06 , C07C409/40 , A61K31/53 , A61K31/445 , A61K31/495 , A61K31/513
CPC分类号： A61K31/164 , A61K31/495 , A61K31/4965 , A61K31/513 , A61K31/53 , C07C237/06
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
摘要翻译： 本发明涉及发现抑制人类免疫缺陷病毒（HIV）复制的新一类化合物以及鉴定这些化合物的方法。 更具体地，已经发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺抑制人血清中HIV的复制。 实施方案包括鉴定修饰的抑制HIV的甘氨酰胺化合物的方法，分离和合成修饰的甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
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公开(公告)号：US20080076824A1
公开(公告)日：2008-03-27
申请号：US11660429
申请日：2005-08-16
申请人： Jan Balzarini , Anders Vahlne , Marita Hogberg , Weimin Tong
发明人： Jan Balzarini , Anders Vahlne , Marita Hogberg , Weimin Tong
CPC分类号： A61K31/164 , A61K31/495 , A61K31/4965 , A61K31/513 , A61K31/53 , C07C237/06
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HUV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
摘要翻译： 本发明涉及发现抑制人类免疫缺陷病毒（HIV）复制的新一类化合物以及鉴定这些化合物的方法。 更具体地，已经发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺抑制人血清中HIV的复制。 实施方案包括鉴定修饰的抑制HUV的甘氨酰胺化合物的方法，分离和合成修饰的甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
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6.发明申请GLYCOSYLATED SPECIFICITY EXCHANGERS THAT INDUCE AN ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY (ADCC) RESPONSE 审中-公开诱导抗体依赖性细胞毒性（ADCC）反应的糖苷化特异性交换剂公开(公告)号：US20090092631A1
公开(公告)日：2009-04-09
申请号：US12055187
申请日：2008-03-25
申请人： Matti Sallberg , Anders Vahlne , Maria Perdomo
发明人： Matti Sallberg , Anders Vahlne , Maria Perdomo
IPC分类号： A61K39/385 , A61P37/04
CPC分类号： C07K14/70514 , C12N2740/16111 , C12N2740/16122
摘要： The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and methods of using said specificity exchangers to treat or prevent human disease are described herein.
摘要翻译： 本发明涉及包含糖或糖缀合物的配体/受体和抗原/抗体特异性交换剂。 本文描述了使这些特异性交换剂和使用所述特异性交换剂治疗或预防人类疾病的方法。
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7.发明授权Peptides for induction of neutralizing antibodies against human immunodeficiency virus 失效用于诱导针对人类免疫缺陷病毒的中和抗体的肽
公开(公告)号：US5589175A
公开(公告)日：1996-12-31
申请号：US410384
申请日：1995-03-27
申请人： Anders Vahlne , Bo Svennerholm , Lars Rymo , Stig Jeansson , Peter Horal
发明人： Anders Vahlne , Bo Svennerholm , Lars Rymo , Stig Jeansson , Peter Horal
IPC分类号： A61K39/21 , A61K39/00 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , A61K38/14 , A61K39/12 , C07K5/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
摘要： In accordance with the present invention, novel peptides corresponding to epitopes of human immunodeficiency virus-1 gp120 protein and analogues and homologs thereof are provided. These peptides can be utilized alone or in combination, uncoupled or coupled to other molecules or substrates. The peptides are useful in immunization against human immunodeficiency virus infection and in production of polyclonal and monoclonal antibodies.
摘要翻译： 根据本发明，提供了对应于人免疫缺陷病毒-1gp120蛋白的表位的新型肽及其类似物及其同系物。 这些肽可以单独使用或组合使用，分离或偶联到其它分子或底物。 这些肽可用于免疫人类免疫缺陷病毒感染和多克隆和单克隆抗体的产生。
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8.发明授权Peptides for HTLV-2 infection diagnosis of, therapy for, vaccination against, for distinguishing between HTLV-1 and HTLV-2 infections and antibodies derived therefrom 失效用于HTLV-2感染诊断的多肽，用于区分HTLV-1和HTLV-2感染的疫苗接种的治疗及其衍生的抗体
公开(公告)号：US5283320A
公开(公告)日：1994-02-01
申请号：US434239
申请日：1989-11-13
申请人： Anders Vahlne , Bo Svennerholm , Lars Rymo , Stig Jeansson , Peter Horal
发明人： Anders Vahlne , Bo Svennerholm , Lars Rymo , Stig Jeansson , Peter Horal
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/14022 , C12N2740/16122 , C12N2740/16222 , Y10S530/826
摘要： Peptides corresponding to epitopes of HTLV-2 proteins are provided. These peptides are immunologically reactive with HTLV-2 specific antibodies. Several of the peptides are sufficiently unreactive to antibodies to HTLV-1 to distinguish between antibodies which recognize HTLV-1 and those which recognize HTLV-2. Thus HTLV-1 infections can be distinguished from HTLV-2 infections. The peptides are useful in assays for detection of HTLV-2 infection or exposure. The peptides are also useful as vaccine compositions against HTLV-2. Antibodies generated in response to immunization by the peptides are also provided.
摘要翻译： 提供了相应于HTLV-2蛋白表位的肽。 这些肽与HTLV-2特异性抗体具有免疫反应性。 几种肽对HTLV-1的抗体没有足够的反应性，以区分识别HTLV-1的抗体和识别HTLV-2的抗体。 因此HTLV-1感染可以区别于HTLV-2感染。 该肽可用于检测HTLV-2感染或暴露的测定中。 肽也可用作抗HTLV-2的疫苗组合物。 还提供了响应于肽的免疫产生的抗体。
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公开(公告)号：US20160251400A1
公开(公告)日：2016-09-01
申请号：US15013773
申请日：2016-02-02
申请人： Albert Collinson , Peter Wagner , Matti Sallberg , Anders Vahlne , Gregor Schurmann , Robert Kamen
发明人： Albert Collinson , Peter Wagner , Matti Sallberg , Anders Vahlne , Gregor Schurmann , Robert Kamen
CPC分类号： C07K14/00 , C12N15/1062 , C40B30/04 , C40B40/08 , C40B50/06
摘要： Disclosed are methods for identifying high affinity adaptor molecules that bind to both a circulating antibody and a target molecule and redirect the specificity of the circulating antibody to the target molecule. Exemplary high affinity adaptor molecules are also provided.
摘要翻译： 公开了用于鉴定结合循环抗体和靶分子并将循环抗体的特异性重定向到靶分子的高亲和性衔接子分子的方法。 还提供了示例性的高亲和性衔接子分子。
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公开(公告)号：US06258932B1
公开(公告)日：2001-07-10
申请号：US09370368
申请日：1999-08-09
申请人： Anders Vahlne
发明人： Anders Vahlne
IPC分类号： A61K3806
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/15022 , C12N2740/16122 , Y10S977/916
摘要： The discovery of peptides in amide form that inhibit viral infection, including human immunodeficiency virus (HIV) infection is disclosed. Methods of use of peptides are also disclosed including use in medicaments for the treatment and prevention of viral infection, such as HIV infection.
摘要翻译： 公开了发现抑制病毒感染的酰胺形式的肽，包括人类免疫缺陷病毒（HIV）感染。 还公开了使用肽的方法，包括在药物中的用途，用于治疗和预防病毒感染，例如HIV感染。
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