公开(公告)号：US07786316B2

公开(公告)日：2010-08-31

申请号：US12503190

申请日：2009-07-15

申请人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

发明人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

IPC分类号： C07D315/00 ,  C07D211/72

CPC分类号： A61K31/435 ,  A61K31/167 ,  A61K31/35 ,  C07D213/69 ,  C07D309/36 ,  C07D309/40

摘要： The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

摘要翻译： 本发明涉及金属蛋白抑制剂，其包括：a。 有机取代基和与其共价结合的至少一个锌结合基团（ZBG）; 或b。 由ZBG由式（I）取代的ZBG：其中X是O或S，并且每个R 1，R 2，R 3和R 4分别是氢或有机基团。 金属蛋白抑制剂可用于预防或治疗与病理性金属蛋白酶活性相关的病理学疾病，病症或症状，和/或通过抑制所述活性而减轻。

公开(公告)号：US07705164B2

公开(公告)日：2010-04-27

申请号：US11568505

申请日：2005-04-28

申请人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

发明人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

IPC分类号： C07D315/00 ,  C07D213/62

CPC分类号： A61K31/435 ,  A61K31/167 ,  A61K31/35 ,  C07D213/69 ,  C07D309/36 ,  C07D309/40

摘要： The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

公开(公告)号：US07579486B2

公开(公告)日：2009-08-25

申请号：US11554475

申请日：2006-10-30

申请人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

发明人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

IPC分类号： C07D315/00

CPC分类号： A61K31/435 ,  A61K31/167 ,  A61K31/35 ,  C07D213/69 ,  C07D309/36 ,  C07D309/40

摘要： The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

摘要翻译： 本发明涉及金属蛋白抑制剂，其包括：a。 有机取代基和与其共价结合的至少一个锌结合基团（ZBG）; 或b。 由ZBG由式（I）取代的ZBG：其中X是O或S，并且每个R 1，R 2，R 3和R 4分别是氢或有机基团。 金属蛋白抑制剂可用于预防或治疗与病理性金属蛋白酶活性相关的病理学疾病，病症或症状，和/或通过抑制所述活性而减轻。

公开(公告)号：US20100173952A1

公开(公告)日：2010-07-08

申请号：US12722623

申请日：2010-03-12

申请人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

发明人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

IPC分类号： A61K31/351 ,  C07D309/40 ,  C07D213/69 ,  A61K31/4412 ,  A61P29/00 ,  A61P9/10

CPC分类号： A61K31/435 ,  A61K31/167 ,  A61K31/35 ,  C07D213/69 ,  C07D309/36 ,  C07D309/40

摘要： The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

摘要翻译： 本发明涉及金属蛋白抑制剂，其包括：a。 有机取代基和与其共价结合的至少一个锌结合基团（ZBG）; 或b。 由ZBG由式（I）取代的ZBG：其中X是O或S，并且每个R 1，R 2，R 3和R 4分别是氢或有机基团。 金属蛋白抑制剂可用于预防或治疗与病理性金属蛋白酶活性相关的病理学疾病，病症或症状，和/或通过抑制所述活性而减轻。

公开(公告)号：US08008510B2

公开(公告)日：2011-08-30

申请号：US12722623

申请日：2010-03-12

申请人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

发明人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

IPC分类号： C07D213/63 ,  C07D315/00

CPC分类号： A61K31/435 ,  A61K31/167 ,  A61K31/35 ,  C07D213/69 ,  C07D309/36 ,  C07D309/40

摘要： The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

摘要翻译： 本发明涉及金属蛋白抑制剂，其包括：a。 有机取代基和与其共价结合的至少一个锌结合基团（ZBG）; 或b。 由ZBG由式（I）取代的ZBG：其中X是O或S，并且每个R 1，R 2，R 3和R 4分别是氢或有机基团。 金属蛋白抑制剂可用于预防或治疗与病理性金属蛋白酶活性相关的病理学疾病，病症或症状，和/或通过抑制所述活性而减轻。

公开(公告)号：US20120135959A1

公开(公告)日：2012-05-31

申请号：US11888237

申请日：2007-07-30

申请人： Seth M. Cohen ,  Faith E. Jacobsen ,  Jana A. Lewis

发明人： Seth M. Cohen ,  Faith E. Jacobsen ,  Jana A. Lewis

IPC分类号： A61K31/69 ,  C12N9/99 ,  A61P35/00 ,  A61P29/00 ,  A61P37/02 ,  A61P31/10 ,  A61P33/00 ,  A61P1/16 ,  A61P9/10 ,  A61P37/08 ,  A61P25/14 ,  A61P27/02 ,  A61P33/02 ,  A61P7/06 ,  C07F5/02

CPC分类号： C12N9/99 ,  A61K31/69 ,  C07F3/003

摘要： Provided herein metalloproteinase inhibitors containing nitrogen or mixed nitrogen/oxygen donating zinc binding groups. Also provided are pharmaceutical compositions containing the compounds and methods of treating preventing or ameliorating the diseases associated with metalloproteinase activity using the compounds and compositions.

摘要翻译： 本文提供了含有氮或混合氮/氧的锌结合基团的金属蛋白酶抑制剂。 还提供了含有化合物的药物组合物和使用该化合物和组合物治疗预防或改善与金属蛋白酶活性相关的疾病的方法。

公开(公告)号：US20120041032A1

公开(公告)日：2012-02-16

申请号：US13209577

申请日：2011-08-15

申请人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

发明人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

IPC分类号： A61K31/4412 ,  A61P29/00 ,  A61P9/10 ,  A61P31/04 ,  A61P35/00

CPC分类号： A61K31/435 ,  A61K31/167 ,  A61K31/35 ,  C07D213/69 ,  C07D309/36 ,  C07D309/40

摘要： The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

摘要翻译： 本发明涉及金属蛋白抑制剂，其包括：a。 有机取代基和与其共价结合的至少一个锌结合基团（ZBG）; 或b。 由ZBG由式（I）取代的ZBG：其中X是O或S，并且每个R 1，R 2，R 3和R 4分别是氢或有机基团。 金属蛋白抑制剂可用于预防或治疗与病理性金属蛋白酶活性相关的病理学疾病，病症或症状，和/或通过抑制所述活性而减轻。

公开(公告)号：US08318945B2

公开(公告)日：2012-11-27

申请号：US13209577

申请日：2011-08-15

申请人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

发明人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

IPC分类号： C07D213/63 ,  A01N43/40

CPC分类号： A61K31/435 ,  A61K31/167 ,  A61K31/35 ,  C07D213/69 ,  C07D309/36 ,  C07D309/40

摘要： The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

摘要翻译： 本发明涉及金属蛋白抑制剂，其包括：a。 有机取代基和与其共价结合的至少一个锌结合基团（ZBG）; 或b。 由ZBG由式（I）取代的ZBG：其中X是O或S，并且每个R 1，R 2，R 3和R 4分别是氢或有机基团。 金属蛋白抑制剂可用于预防或治疗与病理性金属蛋白酶活性相关的病理学疾病，病症或症状，和/或通过抑制所述活性而减轻。

公开(公告)号：US20090286987A1

公开(公告)日：2009-11-19

申请号：US12503190

申请日：2009-07-15

申请人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

发明人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

IPC分类号： C07D213/62 ,  C07D309/32

CPC分类号： A61K31/435 ,  A61K31/167 ,  A61K31/35 ,  C07D213/69 ,  C07D309/36 ,  C07D309/40

摘要： The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

摘要翻译： 本发明涉及金属蛋白抑制剂，其包括：a。 有机取代基和与其共价结合的至少一个锌结合基团（ZBG）; 或b。 由ZBG由式（I）取代的ZBG：其中X是O或S，并且每个R 1，R 2，R 3和R 4分别是氢或有机基团。 金属蛋白抑制剂可用于预防或治疗与病理性金属蛋白酶活性相关的病理学疾病，病症或症状，和/或通过抑制所述活性而减轻。

公开(公告)号：US20080161362A1

公开(公告)日：2008-07-03

申请号：US11568505

申请日：2005-04-28

申请人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

发明人： David T. Puerta ,  Seth M. Cohen ,  Jana A. Lewis

IPC分类号： A61K31/351 ,  A61K31/44 ,  A61P43/00

CPC分类号： A61K31/435 ,  A61K31/167 ,  A61K31/35 ,  C07D213/69 ,  C07D309/36 ,  C07D309/40

摘要： The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

摘要翻译： 本发明涉及金属蛋白抑制剂，其包括：a。 有机取代基和与其共价结合的至少一个锌结合基团（ZBG）; 或b。 由侧链取代的ZBG，其中ZBG为式（I）：其中X为O或S，每个R 1，R 2，R 3 R 4和R 4分别是氢或有机基团。 金属蛋白抑制剂可用于预防或治疗与病理性金属蛋白酶活性相关的病理学疾病，病症或症状，和/或通过抑制所述活性而减轻。