公开(公告)号：US20090035302A1

公开(公告)日：2009-02-05

申请号：US12238087

申请日：2008-09-25

申请人： Adnan M. M. Mjalli ,  Robert C. Andrews ,  Jane M. Shen ,  Robert Rothlein

发明人： Adnan M. M. Mjalli ,  Robert C. Andrews ,  Jane M. Shen ,  Robert Rothlein

IPC分类号： A61K39/395 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/16 ,  A61K38/00

CPC分类号： A61K31/4164 ,  A61K31/4184 ,  A61K31/425

摘要： Disclosed are RAGE antagonist compounds that have the ability to reverse pre-existing amyloidosis. Treatment with the RAGE antagonist compounds described herein may be used to reduce plaque size and improve cognition for subjects in the later stages of Alzheimer's disease. Additionally, the RAGE antagonists described herein may be used to reduce the onset of plaque formation and thereby prevent loss of cognition and other symptoms associated with Alzheimer's Disease and other diseases of amyloid deposition.

摘要翻译： 公开了具有逆转预先存在的淀粉样变性的能力的RAGE拮抗剂化合物。 本文所述的RAGE拮抗剂化合物的治疗可用于减少斑块大小并改善阿尔茨海默病后期受试者的认知。 此外，本文所述的RAGE拮抗剂可用于减少斑块形成的发作，从而防止与阿尔茨海默病和其他淀粉样蛋白沉积疾病相关的认知和其它症状的丧失。