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公开(公告)号:US09145450B2
公开(公告)日:2015-09-29
申请号:US11335878
申请日:2006-01-19
申请人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
发明人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
IPC分类号: C12N15/63 , C07K14/52 , C07K7/06 , C07K7/08 , C12N5/10 , C12P21/06 , C07H21/04 , C12N1/19 , A61K38/00
CPC分类号: C07K14/524 , A61K38/00 , C07K7/06 , C07K7/08 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
摘要翻译: 本发明涉及具有血小板生成活性的化合物,特别是肽或多肽的领域。 本发明的肽和多肽可用于增加哺乳动物中的血小板或血小板前体(例如巨核细胞)。
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公开(公告)号:US08748571B2
公开(公告)日:2014-06-10
申请号:US13278137
申请日:2011-10-20
申请人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
发明人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
CPC分类号: C07K14/524 , A61K38/00 , C07K7/06 , C07K7/08 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
摘要翻译: 本发明涉及具有血小板生成活性的化合物,特别是肽或多肽的领域。 本发明的肽和多肽可用于增加哺乳动物中的血小板或血小板前体(例如巨核细胞)。
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公开(公告)号:US20120208760A1
公开(公告)日:2012-08-16
申请号:US13458744
申请日:2012-04-27
申请人: Chuan-Fa LIU , Ulrich FEIGE , Janet C. CHEETHAM
发明人: Chuan-Fa LIU , Ulrich FEIGE , Janet C. CHEETHAM
CPC分类号: C07K14/524 , A61K38/00 , C07K7/06 , C07K7/08 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
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公开(公告)号:US08044174B2
公开(公告)日:2011-10-25
申请号:US10933133
申请日:2004-09-02
申请人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
发明人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
CPC分类号: C07K14/524 , A61K38/00 , C07K7/06 , C07K7/08 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
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公开(公告)号:US20090186822A1
公开(公告)日:2009-07-23
申请号:US12404047
申请日:2009-03-13
申请人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
发明人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
CPC分类号: C07K14/524 , A61K38/00 , C07K7/06 , C07K7/08 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
摘要翻译: 本发明涉及具有血小板生成活性的化合物,特别是肽或多肽的领域。 本发明的肽和多肽可用于增加哺乳动物中的血小板或血小板前体(例如巨核细胞)。
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公开(公告)号:US20120034657A1
公开(公告)日:2012-02-09
申请号:US13278137
申请日:2011-10-20
申请人: Chuan-Fa LIU , Ulrich FEIGE , Janet C. CHEETHAM
发明人: Chuan-Fa LIU , Ulrich FEIGE , Janet C. CHEETHAM
IPC分类号: C12P21/02
CPC分类号: C07K14/524 , A61K38/00 , C07K7/06 , C07K7/08 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
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公开(公告)号:US08618044B2
公开(公告)日:2013-12-31
申请号:US13458744
申请日:2012-04-27
申请人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
发明人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
CPC分类号: C07K14/524 , A61K38/00 , C07K7/06 , C07K7/08 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
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公开(公告)号:US07994117B2
公开(公告)日:2011-08-09
申请号:US12404047
申请日:2009-03-13
申请人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
发明人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
CPC分类号: C07K14/524 , A61K38/00 , C07K7/06 , C07K7/08 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
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公开(公告)号:US07488590B2
公开(公告)日:2009-02-10
申请号:US10645784
申请日:2003-08-18
CPC分类号: C12N9/6491 , A61K38/00 , A61K47/62 , C07K14/505 , C07K14/52 , C07K14/524 , C07K14/525 , C07K14/545 , C07K2319/00 , C07K2319/30
摘要: Pharmacologically active compounds are prepared by (a) selecting at least one peptide that modulates the activity of AGP-3, (b) preparing a gene construct that comprises at least one said selected sequence, and (c) expressing the pharmacologically active compound in which an Fc domain is covalently linked to the selected peptide. The pharmacologic agent can be expressed in E. coli.
摘要翻译: 通过(a)选择至少一种调节AGP-3的活性的肽,(b)制备包含至少一个所述选择的序列的基因构建体,和(c)表达其药理活性化合物,其中 Fc结构域与选定的肽共价连接。 药理剂可以在大肠杆菌中表达。
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公开(公告)号:US06835809B1
公开(公告)日:2004-12-28
申请号:US09422838
申请日:1999-10-22
申请人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
发明人: Chuan-Fa Liu , Ulrich Feige , Janet C. Cheetham
IPC分类号: A61K3816
CPC分类号: C07K14/524 , A61K38/00 , C07K7/06 , C07K7/08 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
摘要翻译: 本发明涉及具有血小板生成活性的化合物,特别是肽或多肽的领域。 本发明的肽和多肽可用于增加哺乳动物中的血小板或血小板前体(例如巨核细胞)。
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