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公开(公告)号:US20130224115A1
公开(公告)日:2013-08-29
申请号:US13638060
申请日:2011-04-01
申请人: Wei Wang , Jason Shohet , Michel Mawad , Shi Ke
发明人: Wei Wang , Jason Shohet , Michel Mawad , Shi Ke
IPC分类号: C07D209/26
CPC分类号: C07D209/26 , A61K49/0032 , A61K49/0052 , C09B23/0025 , C09B23/0066 , C09B23/086
摘要: Multi-modal tumor imaging of neuroblastoma is essential for tumor staging, response evaluation and detection of relapsed diseased. The present invention provides a norepinephine analogue with a near-infrared (near-IR) dye, W765-BG, that efficiently and stably detects neuroblastoma in vivo using near-IR optical imaging. Confocal microscopy and optical imaging of neuroblastoma xenografts shows cell specific uptake and reveals exceptional tumor retention with a high tumor-to-tissue ratio up to 7 days after injection of W765-BG.
摘要翻译: 神经母细胞瘤的多形态肿瘤成像对肿瘤分期,应答评估和复发性疾病的检测至关重要。 本发明提供了具有近红外(近红外)染料W765-BG的去甲肾上腺素类似物,其使用近红外光学成像在体内有效且稳定地检测神经母细胞瘤。 神经母细胞瘤异种移植物的共聚焦显微镜和光学成像显示细胞特异性摄取,并在注射W765-BG后7天内显示具有高肿瘤组织比的特殊肿瘤保留。