公开(公告)号：US20110172560A1

公开(公告)日：2011-07-14

申请号：US13055536

申请日：2009-07-22

申请人： Javanbakhsh Esfandiari

发明人： Javanbakhsh Esfandiari

IPC分类号： A61B5/00

CPC分类号： A61B10/0045 ,  A61B5/150015 ,  A61B5/150305 ,  A61B5/150351 ,  A61B5/150755 ,  A61B2010/0006

摘要： A kit and a method are disclosed for collecting and preparing a biological sample for testing where the sample is to be mixed with a buffer prior to being tested.

摘要翻译： 公开了一种试剂盒和方法，用于收集和制备用于在待测试之前将样品与缓冲液混合的测试的生物样品。

公开(公告)号：US20110151584A1

公开(公告)日：2011-06-23

申请号：US12964065

申请日：2010-12-09

申请人： Javanbakhsh Esfandiari

发明人： Javanbakhsh Esfandiari

IPC分类号： G01N33/543 ,  C40B60/12 ,  G01N21/75

CPC分类号： G01N33/54386 ,  G01N33/558 ,  Y10S435/805 ,  Y10S436/807 ,  Y10S436/81

摘要： The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test site with immobilized antigens or antibodies or other ligand binding molecules such as aptamers, nucleic acids, etc. located at the junction of the first and second sorbent materials for identifying one or more ligands. The first and second sorbent strips touch each other at the test site location. The test cell may be used to test for pregnancy, HIV (including different HIV antigens or peptides), tuberculosis, prion, urin-analysis/drug, cardiac markers, cancer markers, Chagas, Chlamydia, dental bacteria (SM/LC), influenza A, influenza B, adenovirus, rotavirus, strep A, other bacteria or viruses, etc., and veterinary applications such as CPV, FIV, FeLV, heartworm, etc., although it is not limited to those applications.

摘要翻译： 本发明的系统包括具有限定用于溶液的第一流动路径的第一吸附剂材料的测试电池，限定用于样品的第一流动路径的第二流动路径的第二吸附剂材料和具有固定化抗原或抗体的测试位点 或位于第一和第二吸附剂材料的接合处的其它配体结合分子例如适体，核酸等，用于鉴定一个或多个配体。 第一和第二吸附剂条在测试位置处彼此接触。 测试细胞可用于测试怀孕，HIV（包括不同的HIV抗原或肽），结核病，朊病毒，尿蛋白分析/药物，心脏标志物，癌症标志物，查加斯，衣原体，牙科细菌（SM / LC），流感 A，流感B，腺病毒，轮状病毒，链球菌A，其他细菌或病毒等，以及兽医学应用如CPV，FIV，FeLV，心丝虫等，但不限于这些应用。

公开(公告)号：US20080318341A1

公开(公告)日：2008-12-25

申请号：US11908071

申请日：2006-03-10

申请人： Javanbakhsh Esfandiari

发明人： Javanbakhsh Esfandiari

IPC分类号： G01N33/543 ,  C12M1/00

CPC分类号： G01N33/54386 ,  Y10S435/805 ,  Y10S436/807 ,  Y10S436/81

摘要： The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test site with immobilized antigens or antibodies or other ligand binding molecules such as aptamers, nucleic acids, etc. located at the junction of the first and second sorbent materials for identifying one or more ligands. The first and second sorbent strips touch each other at the test site location. The test cell may be used to test for pregnancy, HIV (including different HIV antigens or peptides), tuberculosis, prion, urin-analysis/drug, cardiac markers, cancer markers, Chagas, Chlamydia, dental bacteria (SM/LC), influenza A, influenza B, adenovirus, rotavirus, strep A, other bacteria or viruses, etc., and veterinary applications such as CPV, FIV, FeLV, heartworm, etc., although it is not limited to those applications.

摘要翻译： 本发明的系统包括具有限定用于溶液的第一流动路径的第一吸附剂材料的测试电池，限定用于样品的第一流动路径的第二流动路径的第二吸附剂材料和具有固定化抗原或抗体的测试位点 或位于第一和第二吸附剂材料的接合处的其它配体结合分子例如适体，核酸等，用于鉴定一个或多个配体。 第一和第二吸附剂条在测试位置处彼此接触。 测试细胞可用于测试怀孕，HIV（包括不同的HIV抗原或肽），结核病，朊病毒，尿蛋白分析/药物，心脏标志物，癌症标志物，查加斯，衣原体，牙科细菌（SM / LC），流感 A，流感B，腺病毒，轮状病毒，链球菌A，其他细菌或病毒等，以及兽医学应用如CPV，FIV，FeLV，心丝虫等，但不限于这些应用。

公开(公告)号：US20070054335A1

公开(公告)日：2007-03-08

申请号：US11222449

申请日：2005-09-08

申请人： Javanbakhsh Esfandiari ,  Konstantin Lyashchenko

发明人： Javanbakhsh Esfandiari ,  Konstantin Lyashchenko

IPC分类号： G01N33/554 ,  C12M1/34

CPC分类号： G01N33/5695 ,  G01N33/558 ,  G01N2469/20 ,  Y10T436/13

摘要： A universal test apparatus for detecting tuberculosis (TB) in any of many different species of non-primate mammals is provided. The universal test apparatus includes a test site having a mycobacterial antigen cocktail comprising ESAT-6/CFP10 and 16 kDa/MPB83 polyfusion antigens, and a tracer having the ESAT-6/CFP10 polyfusion antigen and MPB83 antigen conjugated to latex or colloidal gold. The universal test apparatus is effective across genuses, families and orders of non-primate mammals.

摘要翻译： 提供了用于检测许多不同种类的非灵长类哺乳动物中的任何一种中的结核病（TB）的通用测试装置。 通用试验装置包括具有包含ESAT-6 / CFP10和16kDa / MPB83多重融合抗原的分枝杆菌抗原混合物的试验部位，以及具有与胶乳或胶态金缀合的ESAT-6 / CFP10多聚体抗原和MPB83抗原的示踪剂。 通用测试仪器对非灵长动物哺乳动物的属性，家属和次序有效。

公开(公告)号：US08507259B2

公开(公告)日：2013-08-13

申请号：US12725923

申请日：2010-03-17

申请人： Javanbakhsh Esfandiari

发明人： Javanbakhsh Esfandiari

IPC分类号： C12M1/34

CPC分类号： G01N33/538 ,  G01N33/5695 ,  G01N33/56988

摘要： The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test line or test site with immobilized antigens or antibodies or other ligand binding molecules such as aptamers, nucleic acids, etc. located at the junction of the first and second sorbent materials. The first and second sorbent strips touch each other at the test site location.

摘要翻译： 本发明的系统包括具有限定用于溶液的第一流动路径的第一吸附剂材料的测试电池，限定用于样品的第一流动路径的第二流动路径的第二吸附剂材料，以及固定的测试线或测试位点 抗原或抗体或其它配体结合分子，例如位于第一和第二吸附剂材料的接合处的适配体，核酸等。 第一和第二吸附剂条在测试位置处彼此接触。

公开(公告)号：US20100173397A1

公开(公告)日：2010-07-08

申请号：US12725923

申请日：2010-03-17

申请人： Javanbakhsh Esfandiari

发明人： Javanbakhsh Esfandiari

IPC分类号： C12M1/34

CPC分类号： G01N33/538 ,  G01N33/5695 ,  G01N33/56988

摘要： The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test line or test site with immobilized antigens or antibodies or other ligand binding molecules such as aptamers, nucleic acids, etc. located at the junction of the first and second sorbent materials. The first and second sorbent strips touch each other at the test site location.

摘要翻译： 本发明的系统包括具有限定用于溶液的第一流动路径的第一吸附剂材料的测试电池，限定用于样品的第一流动路径的第二流动路径的第二吸附剂材料，以及固定的测试线或测试位点 抗原或抗体或其它配体结合分子，例如位于第一和第二吸附剂材料的接合处的适配体，核酸等。 第一和第二吸附剂条在测试位置处彼此接触。

公开(公告)号：US20080254444A1

公开(公告)日：2008-10-16

申请号：US12138963

申请日：2008-06-13

申请人： Javanbakhsh Esfandiari

发明人： Javanbakhsh Esfandiari

IPC分类号： C12Q1/70 ,  G01N33/558 ,  C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/815 ,  Y10S436/816 ,  Y10S436/818

摘要： An immunoassay device has a housing defining a first opening for receiving a solution and a second opening through which a liquid sample is deposited, a strip of sorbent material having a test site with immobilized antigen or antibody for the ligand to be tested, and a filter for filtering the sample. The filter is located at the second opening and directly above the test site. The sorbent material defines a horizontal flow path in the housing for the solution from the first opening to the test site. In use, the sample is first applied via the filter to the test site, and then, after the ligand has been captured, a buffer added through the first opening is used to cause a secondary specific binder conjugated to a marker to migrate horizontally by capillary action to the test site where it can bind to the already captured ligand. This immunoassay offer several advantages over the traditional chromatographic immunoassays.

摘要翻译： 免疫测定装置具有壳体，其限定用于接收溶液的第一开口和沉积液体样品的第二开口，具有用于待测配体的固定化抗原或抗体的测试位点的吸附剂材料条，以及过滤器 用于过滤样品。 过滤器位于第二个开口处，直接位于测试位置的上方。 吸附剂材料在壳体中限定了从第一开口到测试部位的溶液的水平流动路径。 在使用中，首先通过过滤器将样品施加到测试部位，然后在配体被捕获后，通过第一个开口加入的缓冲液用于引起缀合到标记物的第二特异性粘合剂通过毛细管水平迁移 作用到测试位置，在那里它可以结合已经捕获的配体。 该免疫测定比传统的色谱免疫测定提供了几个优点。

公开(公告)号：US20070148781A1

公开(公告)日：2007-06-28

申请号：US11683540

申请日：2007-03-08

申请人： Javanbakhsh Esfandiari

发明人： Javanbakhsh Esfandiari

IPC分类号： G01N33/558

CPC分类号： G01N33/538 ,  G01N33/5695 ,  G01N33/56988

摘要： The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test line or test site with immobilized antigens or antibodies or other ligand binding molecules such as aptamers, nucleic acids, etc. located at the junction of the first and second sorbent materials. The first and second sorbent strips touch each other at the test site location.

摘要翻译： 本发明的系统包括具有限定用于溶液的第一流动路径的第一吸附剂材料的测试电池，限定用于样品的第一流动路径的第二流动路径的第二吸附剂材料，以及固定的测试线或测试位点 抗原或抗体或其它配体结合分子，例如位于第一和第二吸附剂材料的接合处的适配体，核酸等。 第一和第二吸附剂条在测试位置处彼此接触。

公开(公告)号：US20120208299A1

公开(公告)日：2012-08-16

申请号：US13024422

申请日：2011-02-10

申请人： Javanbakhsh Esfandiari

发明人： Javanbakhsh Esfandiari

IPC分类号： G01N33/543 ,  G01N21/75 ,  G01N30/96

CPC分类号： G01N33/54386

摘要： Test cells have a first sorbent strip with a sample receiving location and defining a first migration path, a distinct second sorbent strip which receives buffer solution and at least partially defines a second migration path distinct from and elongated relative to the first migration path, conjugate supported by the second strip, a test site located at a junction of the first and second strips and having an immobilized ligand-binding mechanism, and a divider which directs a first amount of the buffer to the first strip to move the sample to the test site and a second amount to the second strip to move the conjugate to the test site. The first and second migration paths have first and second lengths chosen so that ligand in the sample reaches the test site and binds to the immobilized ligand-binding mechanism prior to the conjugate reaching the test site.

摘要翻译： 测试单元具有带有样品接收位置并且限定第一迁移路径的第一吸附剂条，接收缓冲溶液的不同的第二吸附剂条，并且至少部分地限定相对于第一迁移路径不同于和延伸的第二迁移路径， 通过第二条带，位于第一条带和第二条带的连接处并具有固定的配体结合机制的测试位置，以及将第一量的缓冲液引导到第一条带以将样品移动到测试位置的分隔器 以及第二数量到第二条带以将共轭物移动到测试部位。 第一和第二迁移路径具有选择的第一和第二长度，使得样品中的配体到达测试位点并且在缀合物到达测试位点之前结合固定的配体结合机制。

公开(公告)号：US20120003727A1

公开(公告)日：2012-01-05

申请号：US12965258

申请日：2010-12-10

申请人： Javanbakhsh Esfandiari

发明人： Javanbakhsh Esfandiari

IPC分类号： C12M1/34

CPC分类号： G01N33/558 ,  G01N33/54386 ,  G01N33/56988 ,  Y02A50/53

摘要： A fourth generation immunoassay device includes first, second, third, and fourth sorbent or bibulous materials defining first, second, third and fourth horizontal flow paths. The first and second flow paths are for migration of first and second conjugates while the third and fourth flow paths are for the migration of a liquid sample. A first test area for detecting the presence of one or more different antibodies is located at the juncture of the first and third flow paths, and a second test area for detecting the presence of one or more different antigens is located at the juncture of the second and fourth flow paths. A housing is optionally provided for the sorbent materials with an opening for receiving a sample, one or more openings for receiving buffer solution or a conjugate-buffer subcomplex. The housing may also have viewing windows above the detection areas.

摘要翻译： 第四代免疫测定装置包括限定第一，第二，第三和第四水平流动路径的第一，第二，第三和第四吸附剂或吸水材料。 第一和第二流动路径用于第一和第二共轭物的迁移，而第三和第四流动路径用于液体样品的迁移。 用于检测一种或多种不同抗体的存在的第一测试区域位于第一和第三流动路径的交界处，并且用于检测一种或多种不同抗原存在的第二测试区域位于第二 和第四流路。 任选地为吸附剂材料提供具有用于接收样品的开口，用于接收缓冲溶液的一个或多个开口或共轭 - 缓冲液子复合物的壳体。 壳体还可以具有在检测区域上方的观察窗。