公开(公告)号：US20120329879A1

公开(公告)日：2012-12-27

申请号：US13607216

申请日：2012-09-07

申请人： Jena J. Steinle ,  Kimberly P. Williams ,  Jayaprakash Pagadala ,  Duane D. Miller

发明人： Jena J. Steinle ,  Kimberly P. Williams ,  Jayaprakash Pagadala ,  Duane D. Miller

IPC分类号： A61K31/137 ,  C07C215/56 ,  C12N5/071 ,  A61P27/02

CPC分类号： A61K31/137

摘要： Provided herein are methods for improving function in a retinal cell associated with a diabetic condition and for treating a diabetic retinopathic condition in a subject. The methods comprise contacting the retinal cell or administering to the subject a beta-adrenergic receptor agonist or R-isomer thereof such as have the chemical structural formula: where R1 is (CH2)n(CH3)2 or where n is 1 to 4, R2 is H or H.HX, where X is a halide and R3 is O(CH2)mCH3 at one or more of C2-C6, where m is 0 to 4. Also provided are BAR agonists having the structural where R1 is the (CH2)n-phenyl-R2 substituent and the hydroxy-benzene moiety is 1,2-benzene diol or 1,3-benzene diol.

摘要翻译： 本文提供了用于改善与糖尿病状况相关的视网膜细胞的功能和用于治疗受试者的糖尿病视网膜病变症状的方法。 所述方法包括使视网膜细胞接触或向受试者施用β-肾上腺素能受体激动剂或其R-异构体，例如具有以下化学结构式：其中R 1为（CH 2）n（CH 3）2或n为1至4， R2是H或H.HX，其中X是卤素，R3是一个或多个C2-C6上的O（CH2）mCH3，其中m是0-4。还提供了具有结构的BAR激动剂，其中R1是（ CH2）n-苯基-R2取代基，羟基 - 苯部分是1,2-苯二醇或1,3-苯二醇。

公开(公告)号：US07001982B2

公开(公告)日：2006-02-21

申请号：US10403815

申请日：2003-03-31

申请人： Gangavaram Vasantha Madhava Sharma ,  Kondireddi Ravinder Reddy ,  Radha Krishna Palakodety ,  Ajit Chand Kunwar ,  Ravi Sankar Ampapathi ,  Jagannadh Bulusu ,  Jayaprakash Pagadala

发明人： Gangavaram Vasantha Madhava Sharma ,  Kondireddi Ravinder Reddy ,  Radha Krishna Palakodety ,  Ajit Chand Kunwar ,  Ravi Sankar Ampapathi ,  Jagannadh Bulusu ,  Jayaprakash Pagadala

IPC分类号： C07K1/06 ,  C07K2/00 ,  C07K5/023 ,  C07K7/02 ,  C07K9/00

CPC分类号： C07D493/04 ,  C07C237/22 ,  Y10S930/29

摘要： Nonnatural C-linked carbo-β-peptides with robust secondary structures, which involves the synthesis of a new class of β-peptides called C-linked carbo-β-peptides. The compounds are favorably disposed for the formation of stable helical structures and are useful as biologically active carbo-β-peptides. The new class of β-peptides have the following formula The new class of β-peptides are useful as biologically active molecules to disrupt biological interactions of proteins, for molecular design and to synthesize peptide libraries.

摘要翻译： 具有强烈二级结构的非天然C连接的碳-β-肽，其涉及合成称为C-连接的碳-β-肽的新类型的β-肽。 该化合物有利地用于形成稳定的螺旋结构，并且可用作生物活性的碳-β-肽。 新类型的β-肽具有以下化学式：化学式id =“CHEM-US-00001”num =“000”