公开(公告)号：US20180103890A1

公开(公告)日：2018-04-19

申请号：US15534037

申请日：2015-03-11

申请人： Cameron Anthony PIRON ,  Chad Tyler HARRIS ,  Jeff STAINSBY ,  Alexander Gyles PANTHER

发明人： Cameron Anthony PIRON ,  Chad Tyler HARRIS ,  Jeff STAINSBY ,  Alexander Gyles PANTHER

IPC分类号： A61B5/00 ,  A61B5/055 ,  A61K49/10 ,  G01R33/44 ,  G01R33/56 ,  G01R33/50 ,  G01R33/48

CPC分类号： A61B5/414 ,  A61B5/055 ,  A61K49/101 ,  G01R33/445 ,  G01R33/4806 ,  G01R33/50 ,  G01R33/5601

摘要： A magnetic resonance imaging (MRI) system is provided for imaging immune response of soft tissue to therapy by, prior to therapy, administering a contrast agent to the soft tissue; imaging a region of interest using delta relaxation enhanced magnetic resonance (DREMR) to define a functional section; selectively sampling local cells in the functional section; conducting immuno-assay analysis on the sampled local cells; and following therapy, further imaging said region of interest using DREMR to assess immune response of said cells to therapy.

公开(公告)号：US06704593B2

公开(公告)日：2004-03-09

申请号：US09837299

申请日：2001-04-19

申请人： Jeff Stainsby ,  Marshall S. Sussman ,  Graham A. Wright ,  Tzvi Goldman

发明人： Jeff Stainsby ,  Marshall S. Sussman ,  Graham A. Wright ,  Tzvi Goldman

IPC分类号： A61B505

CPC分类号： G01R33/5673 ,  A61B5/0456 ,  A61B5/055 ,  A61B5/7285 ,  G01R33/56509 ,  G01R33/5676 ,  G06F19/00

摘要： Realtime magnetic resonance imaging (MRI) uses cardiac and respiratory monitoring tools to avoid or minimize motion-induced image artifacts. A series of initial MR images are associated with the physiological data from the cardiac, respiratory, or other monitoring tools. The tools provide physiological data in conjunction with anatomic or spatial information such that the optimal gating times (i.e., for acquiring MR image data) in the cardiac and respiratory cycles can be identified and the optimal acquisition durations are identified relative to the physiological data. The process then uses MRI with the identified optimal gating times and acquisition durations to produce a high quality output image of the anatomy of interest. The high quality image can be one or more of the following: a two-dimensional (2D) with a higher signal-to-noise ratio (i.e., higher than the initial MR images), a 2D image with higher spatial resolution, and a three-dimensional (3D) image,

摘要翻译： 实时磁共振成像（MRI）使用心脏和呼吸监测工具来避免或最小化运动诱导的图像伪像。 一系列初始MR图像与来自心脏，呼吸或其他监测工具的生理数据相关联。 这些工具提供结合解剖或空间信息的生理数据，使得可以识别在心脏和呼吸周期中的最佳选通时间（即，用于获取MR图像数据），并且相对于生理数据识别最佳获取持续时间。 然后，该过程使用具有所识别的最佳门控时间和采集持续时间的MRI来产生感兴趣的解剖结构的高质量输出图像。 高质量图像可以是以下的一个或多个：具有较高信噪比（即，高于初始MR图像）的二维（2D），具有较高空间分辨率的2D图像，以及 三维（3D）图像，