公开(公告)号：US06583173B2

公开(公告)日：2003-06-24

申请号：US09967054

申请日：2001-09-28

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffrey Bernard Franciskovich ,  Theodore Goodson, Junior ,  Steven Edward Hall ,  David Kent Herron ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffrey Bernard Franciskovich ,  Theodore Goodson, Junior ,  Steven Edward Hall ,  David Kent Herron ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： A61K31381

CPC分类号： C07D213/75 ,  A61K31/44 ,  C07D209/42 ,  C07D333/38

摘要： This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.