Patent search ap:"John Joseph Masters" Page 1

1.

发明授权
3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake 失效

公开(公告)号：US07417064B2

公开(公告)日：2008-08-26

申请号：US10532657

申请日：2003-10-24

Applicant: Serge Louis Boulet , Sandra Ann Filla , Peter Thaddeus Gallagher , Kevin John Hudziak , Anette Margareta Johansson , Rushad E. Karanjawala , John Joseph Masters , Victor Giulio Matassa , Brian Michael Mathes , Richard Edmund Rathmell , Maria Ann Whatton , Chad Nolan Wolfe

Inventor： Serge Louis Boulet , Sandra Ann Filla , Peter Thaddeus Gallagher , Kevin John Hudziak , Anette Margareta Johansson , Rushad E. Karanjawala , John Joseph Masters , Victor Giulio Matassa , Brian Michael Mathes , Richard Edmund Rathmell , Maria Ann Whatton , Chad Nolan Wolfe

IPC: A61K31/381 , C07D333/64

CPC classification number: C07C217/20 , C07C217/34 , C07D333/54

Abstract: There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n— where n is 0, 1 or 2, —CF3, —CN and —CONH2; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, 5 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n— where n is 0, 1 or 2, nitro, acetyl, —CF3, —SCF3 and cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C1-C4 alkyl; Z is selected from H, OR3 or F, wherein R3 is selected from H, C1-C6 alkyl and phenyl C1-C6 alkyl; R1 and R2 are each independently H or C1-C4 alkyl; with the proviso that, when Z is H, then Y may not be optionally substituted phenyl or optionally substituted naphthyl.

2.

发明授权
Substituted carboxamides 失效
Title translation: 取代的甲酰胺

公开(公告)号：US07163938B2

公开(公告)日：2007-01-16

申请号：US10415756

申请日：2001-11-14

Applicant: David Kent Herron , Sajan Joseph , Angela Lynn Marquart , John Joseph Masters , David Mendel , Gerald Floyd Smith , Philip Parker Waid , Michael Robert Wiley , Ying Kwong Yee

Inventor： David Kent Herron , Sajan Joseph , Angela Lynn Marquart , John Joseph Masters , David Mendel , Gerald Floyd Smith , Philip Parker Waid , Michael Robert Wiley , Ying Kwong Yee

IPC: A61P7/00 , A61K31/44 , A61K31/55 , C07D213/00 , C07D401/12

CPC classification number: C07D213/75 , C07D213/81 , C07D401/12 , C07D401/14

Abstract: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

Abstract translation: 本申请涉及如本文所定义的式I化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。

3.

发明授权
Substituted heterocyclic amides 失效
Title translation: 取代的杂环酰胺

公开(公告)号：US07160878B2

公开(公告)日：2007-01-09

申请号：US10332120

申请日：2001-07-18

Applicant: David Kent Herron , Sajan Joseph , Angela Lynn Marquart , John Joseph Masters , David Mendel , Gerald Floyd Smith , Philip Parker Waid , Michael Robert Wiley , Ying Kwong Yee

Inventor： David Kent Herron , Sajan Joseph , Angela Lynn Marquart , John Joseph Masters , David Mendel , Gerald Floyd Smith , Philip Parker Waid , Michael Robert Wiley , Ying Kwong Yee

IPC: A61P7/02 , A61K31/55 , C07D243/08

CPC classification number: C07D401/14 , C07D237/24 , C07D403/04

Abstract: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

Abstract translation: 本申请涉及本文所定义的式（I）化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。

4.

发明授权
Serine protease inhibitors 失效
Title translation: 丝氨酸蛋白酶抑制剂

公开(公告)号：US06946467B2

公开(公告)日：2005-09-20

申请号：US10030187

申请日：2001-12-06

Applicant: John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer

Inventor： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer

IPC: C07D295/16 , A61K31/395 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/02 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/38 , C07D213/56 , C07D213/74 , C07D231/56 , C07D277/64 , C07D295/18 , C07D295/185 , C07D309/14 , C07D309/32 , C07D309/34 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D521/00

CPC classification number: C07D295/185 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/46 , C07D213/36 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D309/34 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14

Abstract: The compound 1-(indole-6-carbonyl-D-phenylglycinyl)-4-(1-methylpiperidin-4-yl)piperazine and physiologically-tolerable salts thereof are factor Xa inhibitors useful for the treatment of thrombotic disorders.

Abstract translation: 化合物1-（吲哚-6-羰基-D-苯基甘氨酰基）-4-（1-甲基哌啶-4-基）哌嗪及其生理上可耐受的盐是可用于治疗血栓形成障碍的因子Xa抑制剂。

5.

发明授权
Serine protease inhibitors 失效
Title translation: 丝氨酸蛋白酶抑制剂

公开(公告)号：US06855715B1

公开(公告)日：2005-02-15

申请号：US09926712

申请日：2000-06-13

Applicant: John Walter Liebeschuetz , Amanda Jane Lyons , Christopher William Murray , Andrew David Rimmer , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , Phillip John Morgan , Simon James Richards , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley

Inventor： John Walter Liebeschuetz , Amanda Jane Lyons , Christopher William Murray , Andrew David Rimmer , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , Phillip John Morgan , Simon James Richards , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley

IPC: C07D295/16 , A61K31/166 , A61K31/40 , A61K31/4025 , A61K31/433 , A61K31/4439 , A61K31/445 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/497 , A61P1/16 , A61P7/00 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/02 , A61P35/00 , A61P43/00 , C07C237/22 , C07C237/36 , C07C255/60 , C07D207/12 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/00 , C07D211/26 , C07D211/30 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/72 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/02 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/06 , C07D235/08 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/24 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D487/04 , C07D241/04

CPC classification number: C07D401/14 , C07C237/36 , C07C255/60 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/06 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/06 , C07D487/04

Abstract: Compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease inhibitors useful as antithrombotic agents.

Abstract translation: 其中R2，X，L，Y，Cy，Lp，D和n如说明书中所定义的式（I）化合物是用作抗血栓形成剂的丝氨酸蛋白酶抑制剂。

6.

发明授权
Antithrombotic agents 失效

公开(公告)号：US06583173B2

公开(公告)日：2003-06-24

申请号：US09967054

申请日：2001-09-28

Applicant: Douglas Wade Beight , Trelia Joyce Craft , Jeffrey Bernard Franciskovich , Theodore Goodson, Junior , Steven Edward Hall , David Kent Herron , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee

Inventor： Douglas Wade Beight , Trelia Joyce Craft , Jeffrey Bernard Franciskovich , Theodore Goodson, Junior , Steven Edward Hall , David Kent Herron , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee

IPC: A61K31381

CPC classification number: C07D213/75 , A61K31/44 , C07D209/42 , C07D333/38

Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

7.

发明授权
Antithrombotic agents 失效
Title translation: 抗血栓药

公开(公告)号：US06372759B1

公开(公告)日：2002-04-16

申请号：US09445969

申请日：2000-03-20

Applicant: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee

Inventor： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee

IPC: A61K314545

CPC classification number: C07D401/14 , C07D209/08 , C07D209/30 , C07D231/56 , C07D235/06 , C07D401/12 , C07D403/12 , C07D409/12

Abstract: This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

Abstract translation: 本申请涉及式（I）化合物，本文定义的化合物或其前药的药学上可接受的盐，其药物组合物及其作为因子Xa抑制剂的用途，以及其用于其制剂及其中间体。

8.

发明授权
Antithrombotic agents 失效
Title translation: 抗血栓药

公开(公告)号：US06924296B2

公开(公告)日：2005-08-02

申请号：US10333624

申请日：2001-08-06

Applicant: Douglas Wade Beight , John Joseph Masters , Jason Scott Sawyer , Robert Theodore Shuman , Michael Robert Wiley , Ying Kwong Yee

Inventor： Douglas Wade Beight , John Joseph Masters , Jason Scott Sawyer , Robert Theodore Shuman , Michael Robert Wiley , Ying Kwong Yee

IPC: A61P7/02 , A61P9/10 , C07D401/14 , C07D403/12 , A61K31/445

CPC classification number: C07D401/14 , C07D403/12

Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

Abstract translation: 本申请涉及如本文所定义的式I化合物（或其前体药物或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及用于其制备方法及其中间体。