公开(公告)号：US08110187B2

公开(公告)日：2012-02-07

申请号：US10267565

申请日：2002-10-08

申请人： Maurice Kent Gately ,  Ulrich Andreas Gubler ,  Jeffrey David Hulmes ,  Frank John Podlaski ,  Alvin Seth Stern ,  Richard Anthony Chizzonite ,  Yu-Ching Eugene Pan

发明人： Maurice Kent Gately ,  Ulrich Andreas Gubler ,  Jeffrey David Hulmes ,  Frank John Podlaski ,  Alvin Seth Stern ,  Richard Anthony Chizzonite ,  Yu-Ching Eugene Pan

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K14/5434 ,  A61K38/00 ,  C07K16/24 ,  C07K16/244 ,  Y10S530/806

摘要： The present invention is a novel cytokine protein called IL-12 or Cytotoxic Lymphocyte Maturation Factor (CLMF) which is produced and synthesized by human NC-37 B lymphoblastoid cells (American Type Culture Collection, Rockville, Md.). CLMF synergistically induces with low concentrations of IL-2 the cytolytic activity of Lymphokine Activated Killer (LAK) cells, and CLMF is capable of stimulating T-cell growth.Also claimed are the cloned gene for CLMF, its recombination in a suitable vector, the transformed cells containing said vector, the recombinant protein produced by the transformed cells and antibodies to CLMF.

摘要翻译： 本发明是由人类NC-37B淋巴母细胞细胞（American Type Culture Collection，Rockville，Md。）生产和合成的称为IL-12或细胞毒性淋巴细胞成熟因子（CLMF）的新型细胞因子蛋白质。 CLMF协同诱导低浓度的IL-2淋巴因子活化杀伤（LAK）细胞的细胞溶解活性，CLMF能够刺激T细胞生长。 还要求的是用于CLMF的克隆基因，其在合适载体中的重组，含有所述载体的转化细胞，由转化细胞产生的重组蛋白和针对CLMF的抗体。

公开(公告)号：US06683046B1

公开(公告)日：2004-01-27

申请号：US08459151

申请日：1995-06-02

申请人： Maurice Kent Gately ,  Ulrich Andreas Gubler ,  Jeffrey David Hulmes ,  Frank John Podlaski ,  Alvin Seth Stern ,  Richard Anthony Chizzonite ,  Yu-Ching Eugene Pan

发明人： Maurice Kent Gately ,  Ulrich Andreas Gubler ,  Jeffrey David Hulmes ,  Frank John Podlaski ,  Alvin Seth Stern ,  Richard Anthony Chizzonite ,  Yu-Ching Eugene Pan

IPC分类号： C07K1400

CPC分类号： C07K16/24 ,  A61K38/00 ,  C07K14/5434 ,  C07K16/244

摘要： The present invention is a novel cytokine protein called IL-12 or Cytotoxic Lymphocyte Maturation Factor (CLMF) which is produced and synthesized by human NC-37 B lymphoblastoid cells (American Type Culture Collection, Rockville, Md.). CLMF synergistically induces with low concentrations of IL-2 the cytolytic activity of Lymphokine Activated Killer (LAK) cells, and CLMF is capable of stimulating T-cell growth. Also claimed are the cloned gene for CLMF, its recombination in a suitable vector, the transformed cells containing said vector, the recombinant protein produced by the transformed cells and antibodies to CLMF.

摘要翻译： 本发明是由人类NC-37B淋巴母细胞细胞（American Type Culture Collection，Rockville，Md。）生产和合成的称为IL-12或细胞毒性淋巴细胞成熟因子（CLMF）的新型细胞因子蛋白质。 CLMF协同诱导低浓度的IL-2淋巴因子活化杀伤（LAK）细胞的细胞溶解活性，CLMF能够刺激T细胞生长。 还要求的是用于CLMF的克隆基因，其在合适载体中的重组，含有所述载体的转化细胞，由转化细胞产生的重组蛋白和针对CLMF的抗体。

公开(公告)号：US5780597A

公开(公告)日：1998-07-14

申请号：US460061

申请日：1995-06-02

申请人： Maurice Kent Gately ,  Ulrich Andreas Gubler ,  Jeffrey David Hulmes ,  Frank John Podlaski ,  Alvin Seth Stern ,  Richard Anthony Chizzonite ,  Yu-Ching Eugene Pan

发明人： Maurice Kent Gately ,  Ulrich Andreas Gubler ,  Jeffrey David Hulmes ,  Frank John Podlaski ,  Alvin Seth Stern ,  Richard Anthony Chizzonite ,  Yu-Ching Eugene Pan

IPC分类号： A61K38/00 ,  C07K14/54 ,  C07K16/24 ,  C12N5/08 ,  C12P21/08

CPC分类号： C07K14/5434 ,  C07K16/24 ,  C07K16/244 ,  A61K38/00 ,  Y10S530/806

摘要： The present invention relates to antibodies which bind to a novel cytotoxic lymphocyte maturation factor. When bound to the cytotoxic lymphocyte maturation factor, the antibodies can neutralize bioactivity of the factor.

摘要翻译： 本发明涉及结合新型细胞毒性淋巴细胞成熟因子的抗体。 当与细胞毒性淋巴细胞成熟因子结合时，抗体可以中和该因子的生物活性。