公开(公告)号：US20110020332A1

公开(公告)日：2011-01-27

申请号：US12804419

申请日：2010-07-21

Applicant: Mark I. Greene ,  Makoto Matsumata ,  Jeffrey Drebin

Inventor： Mark I. Greene ,  Makoto Matsumata ,  Jeffrey Drebin

IPC: A61K39/395 ,  A61P35/00

CPC classification number: C07K16/32 ,  A61K38/00 ,  A61K2039/505

Abstract: Methods of preventing the transformation of a normal cell into a tumor cell that has p185 on its surface are disclosed. The methods comprise administering an antibody which specifically binds to p185. Methods of preventing the transformation of a normal cell into a tumor cell that has p185 on its surface in an individual at high risk of developing tumors are disclosed.

Abstract translation: 公开了防止正常细胞向其表面具有p185的肿瘤细胞转化的方法。 所述方法包括施用特异性结合p185的抗体。 公开了防止正常细胞转化成肿瘤细胞的方法，所述肿瘤细胞在具有高发展肿瘤风险的个体的表面上具有p185。

公开(公告)号：US20100040618A1

公开(公告)日：2010-02-18

申请号：US12589053

申请日：2009-10-15

Applicant: Mark I. Greene ,  Makoto Katsumata ,  Jeffrey Drebin

Inventor： Mark I. Greene ,  Makoto Katsumata ,  Jeffrey Drebin

IPC: A61K39/395

CPC classification number: C07K16/32 ,  A61K38/00 ,  A61K2039/505

Abstract: Methods of preventing the transformation of a normal cell into a tumor cell that has p185 on its surface are disclosed. The methods comprise administering an antibody which specifically binds to p185. Methods of preventing the transformation of a normal cell into a tumor cell that has p185 on its surface in an individual at high risk of developing tumors are disclosed.

Abstract translation: 公开了防止正常细胞向其表面具有p185的肿瘤细胞转化的方法。 所述方法包括施用特异性结合p185的抗体。 公开了防止正常细胞转化成肿瘤细胞的方法，所述肿瘤细胞在具有高发展肿瘤风险的个体的表面上具有p185。

公开(公告)号：US20180057603A1

公开(公告)日：2018-03-01

申请号：US15019924

申请日：2016-02-09

Applicant: Mark Greene ,  Hongtao Zhang ,  Hiromichi Tsuchiya ,  Yasuhiro Nagai ,  Lian Lam ,  Aaron Runkle ,  Jeffrey Drebin ,  Mei Qing Ji

Inventor： Mark Greene ,  Hongtao Zhang ,  Hiromichi Tsuchiya ,  Yasuhiro Nagai ,  Lian Lam ,  Aaron Runkle ,  Jeffrey Drebin ,  Mei Qing Ji

IPC: C07K16/30 ,  A61K38/02 ,  A61K39/395

CPC classification number: C07K16/3076 ,  A61K31/337 ,  A61K31/517 ,  A61K38/02 ,  A61K38/217 ,  A61K39/395 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/2818 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/70 ,  C07K2319/75 ,  A61K2300/00

Abstract: The present invention provides a fusion proteins comprising (a) a first stretch of consecutive amino acids, the sequence of which is the sequence of an anti-p185her2/neu polypeptide or an anti-EGFR polypeptide; (b) a second stretch of consecutive amino acids, the sequence of which is the sequence of a polypeptide capable of binding at least one polypeptide other than p185her2/neu or EGFR; and (c) a third stretch of consecutive amino acids, the sequence of which comprises the sequence of a biologically active portion of interferon-gamma (IFNγ), wherein (b) is located at the carboxy-terminal end of (a), and (c) is located at the carboxy-terminal end of (b). The present invention provides methods and compositions treating or preventing cancer and for sensitizing cancer cells to radiation or a chemotherapeutic agent, which comprises administering i) an anti-p185her2/neu antibody, an anti-EGFR antibody or an erbB kinase inhibitor and interferon-gamma (IFNγ); or ii) a fusion protein of the invention.

公开(公告)号：US20110274688A1

公开(公告)日：2011-11-10

申请号：US13186299

申请日：2011-07-19

Applicant: Mark I. Greene ,  Makoto Katsumata ,  Jeffrey Drebin

Inventor： Mark I. Greene ,  Makoto Katsumata ,  Jeffrey Drebin

IPC: A61K39/395 ,  A61P35/00

CPC classification number: C07K16/32 ,  A61K38/00 ,  A61K2039/505

Abstract: Methods of preventing the transformation of a normal cell into a tumor cell that has p185 on its surface are disclosed. The methods comprise administering an antibody which specifically binds to p185. Methods of preventing the transformation of a normal cell into a tumor cell that has p185 on its surface in an individual at high risk of developing tumors are disclosed.

Abstract translation: 公开了防止正常细胞向其表面具有p185的肿瘤细胞转化的方法。 所述方法包括施用特异性结合p185的抗体。 公开了防止正常细胞转化成肿瘤细胞的方法，所述肿瘤细胞在具有高发展肿瘤风险的个体的表面上具有p185。

公开(公告)号：US20090104191A1

公开(公告)日：2009-04-23

申请号：US12316299

申请日：2008-12-10

Applicant: Mark I. Greene ,  Makoto Katsumata ,  Jeffrey Drebin

Inventor： Mark I. Greene ,  Makoto Katsumata ,  Jeffrey Drebin

IPC: A61K39/395

CPC classification number: C07K16/32 ,  A61K38/00 ,  A61K2039/505

Abstract: Methods of preventing the transformation of a normal cell into a tumor cell that has p185 on its surface are disclosed. The methods comprise administering an antibody which specifically binds to p185. Methods of preventing the transformation of a normal cell into a tumor cell that has p185 on its surface in an individual at high risk of developing tumors are disclosed.

Abstract translation: 公开了防止正常细胞向其表面具有p185的肿瘤细胞转化的方法。 所述方法包括施用特异性结合p185的抗体。 公开了防止正常细胞转化成肿瘤细胞的方法，所述肿瘤细胞在具有高发展肿瘤风险的个体的表面上具有p185。