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公开(公告)号：US20230173190A1
公开(公告)日：2023-06-08
申请号：US17997883
申请日：2021-05-04
申请人： Armando Miguel BARBOSA DE ABREU E SOUSA , Miguel Afonso BARBOSA DE ABREU SOUSA E BATISTA , Jens HOLM
发明人： Armando Miguel BARBOSA DE ABREU E SOUSA , Miguel Afonso BARBOSA DE ABREU SOUSA E BATISTA , Jens HOLM
CPC分类号： A61M5/3234 , A61M5/46 , A61M5/282 , A61M5/14244 , A61M2205/273
摘要： An injection capsule for medical use, having:
a closed main body having an internal reservoir receiving a medical substance in liquid form to be administered to a target subject; and
a needle, having one or more inlet bores located at its lateral skirt and configured to allow the inlet of the medical substance within its tubular body. The needle is activatable between a rest configuration, wherein it is housed within the reservoir and immersed in the medical substance, and an injection configuration, wherein it is pushed outside the closed main body to administer the medical substance by injection to the target subject.-
公开(公告)号：US20110052639A1
公开(公告)日：2011-03-03
申请号：US12837242
申请日：2010-07-15
申请人： Jens Holm , Mercedes Ferreras
发明人： Jens Holm , Mercedes Ferreras
CPC分类号： C07K14/415 , A61K38/00 , A61K2039/53
摘要： Novel recombinant allergens with multiple mutations and reduced IgE binding affinity are disclosed. The allergens are mutants of naturally occurring allergens. The overall α-carbon backbone tertiary structure is essentially preserved. Also disclosed is a method for preparing such recombinant allergens as well as uses thereof.
摘要翻译： 公开了具有多重突变和降低的IgE结合亲和力的新型重组变应原。 过敏原是天然存在的变应原的突变体。 总体上，α-碳骨架三级结构基本保持不变。 还公开了制备这种重组变应原及其应用的方法。
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公开(公告)号：US20090054625A1
公开(公告)日：2009-02-26
申请号：US12128181
申请日：2008-05-28
申请人： Jens Holm , Jorgen N. Larsen
发明人： Jens Holm , Jorgen N. Larsen
IPC分类号： C07K1/02
CPC分类号： C07K14/415 , A61K38/00 , A61K2039/57 , C07H21/04 , C07K14/43531 , C07K14/43568 , C07K2299/00
摘要： The present invention relates to novel recombinant protein variants that are useful as immunotherapeutic components. Also the present invention relates to DNA sequences encoding said protein variants as well as compositions comprising said protein variants.
摘要翻译： 本发明涉及可用作免疫治疗成分的新型重组蛋白变体。 本发明还涉及编码所述蛋白质变体的DNA序列以及包含所述蛋白质变体的组合物。
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公开(公告)号：US07384635B2
公开(公告)日：2008-06-10
申请号：US10698855
申请日：2003-10-31
申请人： Jens Holm , Jorgen N. Larsen
发明人： Jens Holm , Jorgen N. Larsen
CPC分类号： C07K14/415 , A61K38/00 , A61K2039/57 , C07H21/04 , C07K14/43531 , C07K14/43568 , C07K2299/00
摘要： The present invention relates to novel recombinant protein variants that are useful as immunotherapeutic components. Also the present invention relates to DNA sequences encoding said protein variants as well as compositions comprising said protein variants.
摘要翻译： 本发明涉及可用作免疫治疗成分的新型重组蛋白变体。 本发明还涉及编码所述蛋白质变体的DNA序列以及包含所述蛋白质变体的组合物。
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公开(公告)号：US20070079897A1
公开(公告)日：2007-04-12
申请号：US10576750
申请日：2004-10-19
申请人： Jens Holm
发明人： Jens Holm
IPC分类号： B67C11/04
摘要： A funnel for pouring liquid into a receptacle is collapsible and is stored in the receptacle when not in use. The funnel is automatically unfolded upon opening the receptacle lid. The funnel has no risk of is unfolding in the receptacle. A tube fixed to the base plate includes displaceable means that are fastened to the lid. The tube is terminated at the top with an arrester for securing the displaceable means. The foldable funnel is disposed inside the existing receptacle, and the funnel is unfolded as soon as the lid is lifted. The opened lid is disposed at the side of the funnel completely outside the funnel circumference so as not to interfere with filling. Placing the lid upon the tube, centering the lid on the funnel and pushing downward closes the receptacle and folds the funnel, which disappears downward into the receptacle.
摘要翻译： 用于将液体倒入容器的漏斗是可折叠的，并且在不使用时存储在容器中。 漏斗在打开插座盖时自动展开。 漏斗没有在容器中展开的风险。 固定在基板上的管子包括固定在盖子上的可移动的装置。 管子在顶部端接，用避雷器固定可移位装置。 可折叠漏斗设置在现有的容器内部，并且一旦盖被提起，漏斗就展开。 打开的盖子在漏斗的外侧完全设置在漏斗侧，以免干扰填充。 将盖放置在管上，将盖定位在漏斗上并向下推动关闭容器并折叠漏斗，漏斗向下消失到容器中。
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