公开(公告)号：US20050043361A1

公开(公告)日：2005-02-24

申请号：US10728679

申请日：2003-12-05

申请人： Jerry Colca ,  William McDonald

发明人： Jerry Colca ,  William McDonald

IPC分类号： C07K14/47 ,  C07K14/705 ,  A61K31/4439

CPC分类号： C07K14/47 ,  C07K14/705

摘要： The invention relates generally to a family of polypeptides from mitochondrial membranes, which bind insulin sensitizing, antidiabetic thiazolodinediones, and nucleic acid sequences encoding the family of polypeptides. The invention relates to methods of identifying therapeutic agents that bind to the polypeptides of the present invention. The invention further relates to methods useful for treating or modulating metabolic disorders in mammals in need of such biological effect.

摘要翻译： 本发明一般涉及来自线粒体膜的多肽结合胰岛素敏化，抗糖尿病性噻唑烷二酮类和编码多肽家族的核酸序列。 本发明涉及鉴定结合本发明多肽的治疗剂的方法。 本发明还涉及可用于治疗或调节需要这种生物效应的哺乳动物代谢紊乱的方法。