公开(公告)号：US08211649B2

公开(公告)日：2012-07-03

申请号：US12295572

申请日：2007-03-30

申请人： Thi-Sau Migone ,  Jerry L. Klein ,  Yasuhiro Oki ,  Anas Younes

发明人： Thi-Sau Migone ,  Jerry L. Klein ,  Yasuhiro Oki ,  Anas Younes

IPC分类号： G01N33/53 ,  G01N33/564 ,  G01N33/566 ,  G01N33/96 ,  C07K14/435 ,  C07K16/18

CPC分类号： C07K16/24 ,  A61K51/088 ,  A61K51/1021 ,  C07K14/525 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76

摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.

摘要翻译： 本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。 还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。