公开(公告)号：US20100056608A1

公开(公告)日：2010-03-04

申请号：US12515344

申请日：2007-11-19

Applicant: Johan Bjorkegren ,  Jesper Tegner

Inventor： Johan Bjorkegren ,  Jesper Tegner

IPC: A61K31/7088 ,  C12Q1/68 ,  C12N5/10 ,  A01K67/00

CPC classification number: G01N33/5023 ,  A61K38/1709 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/323 ,  Y02A50/465

Abstract: The present invention relates to a method for identifying a compound as a candidate drug, comprising the steps a. bringing said compound into contact with a cell expressing the genes CYPC, AGPAT3, AGL, PVRL2, HMGB 3, HSDL2; and b. analyzing if said compound modulates the expression of at least one of said genes. It also relates to a method for identifying a compound as a candidate drug, comprising the steps a. bringing said compound into contact with a cell expressing the gene LDB2; and b. analyzing if said compound modulates the expression of LDB2. The invention further relates to genetically modified cells and animals useful in such methods and to methods for treatment of atherosclerosis, atherosclerosis-related diseases or inflammatory diseases, comprising the use of such identified compounds.

Abstract translation: 本发明涉及鉴定化合物作为候选药物的方法，包括步骤a。 使所述化合物与表达CYPC，AGPAT3，AGL，PVRL2，HMGB3，HSDL2基因的细胞接触; 和b。 分析所述化合物是否调节至少一种所述基因的表达。 它还涉及用于鉴定化合物作为候选药物的方法，包括步骤a。 使所述化合物与表达基因LDB2的细胞接触; 和b。 分析所述化合物是否调节LDB2的表达。 本发明还涉及可用于这些方法的遗传修饰的细胞和动物，以及用于治疗动脉粥样硬化，动脉粥样硬化相关疾病或炎性疾病的方法，其包括使用这种鉴定的化合物。

公开(公告)号：US20060293873A1

公开(公告)日：2006-12-28

申请号：US10506734

申请日：2003-03-05

Applicant: Timothy Gardner ,  James Collins ,  Diego di Bernardo ,  Jesper Tegner ,  Man Yeung

Inventor： Timothy Gardner ,  James Collins ,  Diego di Bernardo ,  Jesper Tegner ,  Man Yeung

IPC: G06G7/48 ,  G06G7/58

CPC classification number: G16B5/00 ,  G16B20/00 ,  G16B40/00

Abstract: The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems.

Abstract translation: 本发明提供了存储在用于构建生物网络的模型的计算机可读介质上的方法和伴随的基于计算机的系统和计算机可执行代码。 本发明还提供了用于在生物网络上执行灵敏度分析并且用于识别网络和整个网络中物种的主要调节剂的方法。 此外，本发明提供用于鉴定诸如由化合物暴露或环境变化引起的扰动目标的方法。 本发明还提供用于鉴定有助于生物系统表型差异的表型介质的方法。