公开(公告)号：US07709537B1

公开(公告)日：2010-05-04

申请号：US10110206

申请日：2000-10-18

Applicant: Kazuo Nagai ,  Jetae Woo ,  Yoshiro Sato ,  Kouichiro Hashimoto ,  Naoki Taketomo ,  Nobuo Yoda ,  Hiroshi Tsuchida

Inventor： Kazuo Nagai ,  Jetae Woo ,  Yoshiro Sato ,  Kouichiro Hashimoto ,  Naoki Taketomo ,  Nobuo Yoda ,  Hiroshi Tsuchida

IPC: A01N31/08 ,  A61K31/05 ,  A01N29/10 ,  A01N29/02 ,  A61K31/02 ,  A01N27/00 ,  A61K31/015

CPC classification number: A61K35/741 ,  A23L29/065 ,  A23L33/10 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2320/25 ,  A61K31/122 ,  A61K31/195 ,  A61K31/196 ,  A61K35/747 ,  A23V2250/206 ,  A23V2250/30 ,  A23V2250/714

Abstract: This invention relates to drinks and foods having osteogenetic function, each of which comprises as an active ingredient an effective amount of a culture of a propionic acid bacterium and/or a lactic acid bacterium, said culture containing 2-amino-3-carboxy-1,4-naphthoquinone; and preventives and/or remedies for metabolic bone diseases, each of which comprises as an active ingredient a naphthoquinone compound selected from the group consisting of 2-amino-3-carboxy-1,4-naphthoquinone, 1,4-naphthoquinone, 2-hydroxy-1,4-naphthoquinone, 2,3-dichloro-1,4-naphthoquinone, 5-hydroxy-1,4-naphthoquinone, 8-hydroxy-1,4-naphthoquinone, 2-(α-hydroxy-δ-methylpentenyl)-5,8-dihydroxy-1,4-naphthoquinone and salts thereof. These cultures and naphthoquinones promote bone metabolism and increase bone mass and bone strength.

Abstract translation: 本发明涉及具有成骨功能的饮料和食品，其每一种都含有有效量的丙酸细菌和/或乳酸菌的培养物作为活性成分，所述培养物含有2-氨基-3-羧基-1 ，4-萘醌; 以及代谢性骨疾病的预防剂和/或补救剂，其各自包含作为活性成分的选自2-氨基-3-羧基-1,4-萘醌，1,4-萘醌，2-甲基苯酚， 羟基-1,4-萘醌，2,3-二氯-1,4-萘醌，5-羟基-1,4-萘醌，8-羟基-1,4-萘醌，2-（α-羟基-δ-甲基戊烯基 ）-5,8-二羟基-1,4-萘醌及其盐。 这些培养物和萘醌促进骨代谢并增加骨量和骨强度。

公开(公告)号：US20060093651A1

公开(公告)日：2006-05-04

申请号：US11295601

申请日：2005-12-07

Applicant: Kazuo Nagai ,  Jetae Woo ,  Yoshiro Sato ,  Kouichiro Hashimoto ,  Naoki Taketomo ,  Nobuo Yoda ,  Hiroshi Tsuchida

Inventor： Kazuo Nagai ,  Jetae Woo ,  Yoshiro Sato ,  Kouichiro Hashimoto ,  Naoki Taketomo ,  Nobuo Yoda ,  Hiroshi Tsuchida

IPC: A61K35/74 ,  A61K47/00 ,  A61K31/12

CPC classification number: A61K35/741 ,  A23L29/065 ,  A23L33/10 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2320/25 ,  A61K31/122 ,  A61K31/195 ,  A61K31/196 ,  A61K35/747 ,  A23V2250/206 ,  A23V2250/30 ,  A23V2250/714

Abstract: This invention relates to drinks and foods having osteogenetic function, each of which comprises as an active ingredient an effective amount of a culture of a propionic acid bacterium and/or a lactic acid bacterium, said culture containing 2-amino-3-carboxy-1,4-naphthoquinone; and preventives and/or remedies for metabolic bone diseases, each of which comprises as an active ingredient a naphthoquinone compound selected from the group consisting of 2-amino-3-carboxy-1,4-naphthoquinone, 1,4-naphthoquinone, 2-hydroxy-1,4-naphthoquinone, 2,3-dichloro-1,4-naphthoquinone, 5-hydroxy-1,4-naphthoquinone, 8-hydroxy-1,4-naphthoquinone, 2-(α-hydroxy-δ-methylpentenyl)-5,8-dihydroxy-1,4-naphthoquinone and salts thereof. These cultures and naphthoquinones promote bone metabolism and increase bone mass and bone strength.

Abstract translation: 本发明涉及具有成骨功能的饮料和食品，其每一种都含有有效量的丙酸细菌和/或乳酸菌的培养物作为活性成分，所述培养物含有2-氨基-3-羧基-1 ，4-萘醌; 以及代谢性骨疾病的预防剂和/或补救剂，其各自包含作为活性成分的选自2-氨基-3-羧基-1,4-萘醌，1,4-萘醌，2-甲基苯酚， 羟基-1,4-萘醌，2,3-二氯-1,4-萘醌，5-羟基-1,4-萘醌，8-羟基-1,4-萘醌，2-（α-羟基-δ-甲基戊烯基 ）-5,8-二羟基-1,4-萘醌及其盐。 这些培养物和萘醌促进骨代谢并增加骨量和骨强度。