公开(公告)号：US07071341B2

公开(公告)日：2006-07-04

申请号：US10403034

申请日：2003-04-01

Applicant: Janaswamy Madhusudana Rao ,  Rao Jagadeeshwar Rao ,  Upparapalli Sampath Kumar ,  Singireddy Venkat Reddy ,  Ashok Kumar Tiwari ,  Jhillusingh Yadav ,  Kondapuram Vijaya Raghavan

Inventor： Janaswamy Madhusudana Rao ,  Rao Jagadeeshwar Rao ,  Upparapalli Sampath Kumar ,  Singireddy Venkat Reddy ,  Ashok Kumar Tiwari ,  Jhillusingh Yadav ,  Kondapuram Vijaya Raghavan

IPC: C07D311/74

CPC classification number: C07D311/64 ,  A61K31/353

Abstract: The present invention provides novel α-glucosidase inhibitory compound (−)-mesquitol and its analogs isolated in significant yield from traditional medicinal plant Dichrostachys cinerea and further modification of (−)-mesquitol to enhance the α-glucosidase inhibitory potential; the invention also identifies the usage of (−)-mesquitol and its analogues, based on their α-glucosidase inhibitory activity, as broad based potential therapeutics as antihyperglycernic, antidiabatic, antiobesity, antiviral, anticancer, immunestimulants and the like.

Abstract translation: 本发明提供了新型α-葡萄糖苷酶抑制化合物（ - ） - 精蛋白醇及其类似物，其从传统药用植物Dichrostachys cinerea中显着分离，并进一步修饰（ - ） - mesquitol以增强α-葡萄糖苷酶的抑制潜力; 本发明还基于其α-葡糖苷酶抑制活性鉴定了（ - ） - 麦芽糖醇及其类似物作为抗高血糖，抗绝育，抗肥胖，抗病毒，抗癌，免疫增强剂等的广泛潜在治疗剂的用途。