公开(公告)号：US20130078221A1

公开(公告)日：2013-03-28

申请号：US13434232

申请日：2012-03-29

申请人： Kyung Sun KANG ,  Oh Kyung KWON ,  Yun Hyeok JEONG ,  Ji Hey LIM ,  Chang Soo JUNG

发明人： Kyung Sun KANG ,  Oh Kyung KWON ,  Yun Hyeok JEONG ,  Ji Hey LIM ,  Chang Soo JUNG

IPC分类号： A61K35/48 ,  A61K35/50 ,  A61K35/34

CPC分类号： A61K35/51 ,  A61K35/34 ,  A61K35/50 ,  C12N5/0607

摘要： The present invention relates to multipotent adult stem cells derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart, and a method for preparing the same as well as a cellular therapeutic agent containing the same, more specifically, to a multipotent adult stem cell isolated by culturing an eukaryotic cell derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart in a FBS-containing medium and a method for preparing the same. Adult stem cells according to the present invention have characteristics highly similar to human mesenchymal stem cells as well as remarkable cell growth at the initial step compared to human UCB-derived mesenchymal stem cells so that the cells are useful to treat canine incurable diseases and difficult-to-cure diseases. Furthermore, multipotent adult stem cells are effective to treat musculoskeletal diseases and neural diseases.

摘要翻译： 本发明涉及来自犬脐带血的多潜能成体干细胞，来自犬胎心的胎盘血液和血液样品，以及其制备方法以及含有该成体干细胞的细胞治疗剂，更具体地，涉及多潜能 通过在含FBS的培养基中培养源自犬脐带血，胎盘血液和犬胎儿心脏的血液样品的真核细胞分离的成体干细胞及其制备方法。 根据本发明的成体干细胞具有与人间充质干细胞高度相似的特征，以及与人UCB衍生的间充质干细胞相比，在初始步骤中显着的细胞生长，使得细胞可用于治疗犬不治之症， 治愈疾病。 此外，多能成体干细胞有效治疗肌肉骨骼疾病和神经疾病。

公开(公告)号：US20100021436A1

公开(公告)日：2010-01-28

申请号：US12300281

申请日：2007-05-12

申请人： Kyung Sun Kang ,  Oh Kyung Kwon ,  Yun Hyeok Jeong ,  Ji Hey Lim ,  Chang Soo Jung

发明人： Kyung Sun Kang ,  Oh Kyung Kwon ,  Yun Hyeok Jeong ,  Ji Hey Lim ,  Chang Soo Jung

IPC分类号： A61K35/12 ,  C12N5/074

CPC分类号： A61K35/51 ,  A61K35/34 ,  A61K35/50 ,  C12N5/0607

摘要： The present invention relates to multipotent adult stem cells derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart, and a method for preparing the same as well as a cellular therapeutic agent containing the same, more specifically, to a multipotent adult stem cell isolated by culturing an eukaryotic cell derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart in a FBS-containing medium and a method for preparing the same. Adult stem cells according to the present invention are derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart. The adult stem cells have characteristics highly similar to human mesenchymal stem cells as well as remarkable cell growth at the initial step compared to human UCB-derived mesenchymal stem cells so that the cells are useful to treat canine incurable diseases and difficult-to-cure diseases. Furthermore, multipotent adult stem cells are effective to treat musculoskeletal diseases and neural diseases due to the ability to differentiate into osteogenic cells and neural cells.

摘要翻译： 本发明涉及来自犬脐带血的多潜能成体干细胞，来自犬胎心的胎盘血液和血液样品，以及其制备方法以及含有该成体干细胞的细胞治疗剂，更具体地，涉及多潜能 通过在含FBS的培养基中培养源自犬脐带血，胎盘血液和犬胎儿心脏的血液样品的真核细胞分离的成体干细胞及其制备方法。 根据本发明的成体干细胞衍生自犬脐带血，胎盘血和来自犬胎心的血液样品。 与人UCB来源的间充质干细胞相比，成体干细胞具有与人间充质干细胞高度相似的特征，并且在初始步骤中显着的细胞生长，使得细胞可用于治疗犬不治之症和难以治愈的疾病 。 此外，多能成体干细胞由于分化成成骨细胞和神经细胞的能力而有效治疗肌肉骨骼疾病和神经疾病。