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公开(公告)号:US06168913A
公开(公告)日:2001-01-02
申请号:US08949987
申请日:1997-10-14
申请人: Jill Edie Hochlowski , Thomas J. Sowin , Daniel W. Norbeck , Warren S. Wade , David N. Whittern
发明人: Jill Edie Hochlowski , Thomas J. Sowin , Daniel W. Norbeck , Warren S. Wade , David N. Whittern
IPC分类号: C12Q100
CPC分类号: C40B50/16 , B01J2219/00576 , C07K1/047 , C40B99/00
摘要: The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching “tags” that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead.
摘要翻译: 本发明涉及通过以组合和/或比率附着包含含氟化合物的“标签”,在多个固体支持物上合成的组合化学文库编码。 可以通过氟核磁共振光谱法附着到固体支持物上来对标签进行解码,以跟踪单个珠粒的反应历程,并确定附着在珠粒上的文库的特定成员。
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公开(公告)号:US06355490B1
公开(公告)日:2002-03-12
申请号:US08923206
申请日:1997-09-04
申请人: Jill Edie Hochlowski , Thomas J. Sowin , Daniel W. Norbeck , Anne-Laure Marie Grillot , Rolf E. Swenson
发明人: Jill Edie Hochlowski , Thomas J. Sowin , Daniel W. Norbeck , Anne-Laure Marie Grillot , Rolf E. Swenson
IPC分类号: G01N33543
CPC分类号: C40B50/16 , B01J2219/005 , B01J2219/00572 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/0072 , C07B2200/11 , C40B70/00 , Y10T436/13
摘要: The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or raman spectroscopy when directly attached to the support.
摘要翻译: 本发明涉及编码和鉴定在经历混合和分裂合成的多个固体支持物上合成的化学组合文库的各个成员的方法。 该过程提供了用固定支持物附接的编码标识符来标记固体支持物,并且当直接连接到支持物时可以通过红外或拉曼光谱进行解码。
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公开(公告)号:US06274385B1
公开(公告)日:2001-08-14
申请号:US09370437
申请日:1999-08-09
申请人: Jill Edie Hochlowski , Thomas J. Sowin , Daniel W. Norbeck , Anne-Laure Marie Grillot , Rolf E. Swenson
发明人: Jill Edie Hochlowski , Thomas J. Sowin , Daniel W. Norbeck , Anne-Laure Marie Grillot , Rolf E. Swenson
IPC分类号: G01N33543
CPC分类号: C40B50/16 , B01J2219/005 , B01J2219/00572 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/0072 , C07B2200/11 , C40B70/00 , Y10T436/13
摘要: The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or raman spectroscopy when directly attached to the support.
摘要翻译: 本发明涉及编码和鉴定在经历混合和分裂合成的多个固体支持物上合成的化学组合文库的各个成员的方法。 该过程提供了用固定支持物附接的编码标识符来标记固体支持物,并且当直接连接到支持物时可以通过红外或拉曼光谱进行解码。
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