公开(公告)号：US12115510B2

公开(公告)日：2024-10-15

申请号：US17695734

申请日：2022-03-15

Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC

Inventor： Bichlien Hoang Nguyen ,  Karin Strauss ,  Hsing-Yeh Parker

IPC: B01J19/00 ,  C07K1/04 ,  C25D5/16 ,  C25D5/48 ,  C25D17/10

CPC classification number: B01J19/0046 ,  C07K1/042 ,  C25D5/16 ,  C25D5/48 ,  C25D17/10 ,  B01J2219/00497 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00612 ,  B01J2219/00722 ,  B01J2219/00725

Abstract: High surface area coatings are applied to solid substrates to increase the surface area available for solid-phase synthesis of polymers. The high surface area coatings use three-dimensional space to provide more area for functional groups to bind polymers than an untreated solid substrate. The polymers may be oligonucleotides, polypeptides, or another type of polymer. The solid substrate is a rigid supportive layer made from a material such as glass, a silicon material, a metal material, and plastic. The coating may be thin films, hydrogels, microparticles. The coating may be made from a metal oxide, a high-κ dielectric, a low-κ dielectric, an etched metal, a carbon material, or an organic polymer. The functional groups may be hydroxyl groups, amine groups, thiolate groups, alkenes, n-alkenes, alkalines, N-Hydroxysuccinimide (NHS)-activated esters, polyaniline, aminosilane groups, silanized oxides, oligothiophenes, and diazonium compounds. Techniques for applying coatings to solid substrates and attaching functional groups are also disclosed.

公开(公告)号：US20230321625A1

公开(公告)日：2023-10-12

申请号：US18110846

申请日：2023-02-16

Applicant: Avery Digital Data, Inc.

Inventor： Barry Merriman ,  Ryan de Ridder ,  Matthew T. Holden ,  Tim Geiser

IPC: B01J19/00 ,  C40B40/06

CPC classification number: B01J19/0046 ,  C40B40/06 ,  B01J2219/00722 ,  B01J2219/00653 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00713

Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.

公开(公告)号：US10081588B2

公开(公告)日：2018-09-25

申请号：US15101251

申请日：2014-12-03

Applicant: ResCurve, LLC

Inventor： Sagar B. Gadewar ,  Brian Christopher Vicente ,  Peter K. Stoimenov

IPC: C07C67/03 ,  C07C29/34 ,  C07C67/40 ,  B01D3/00 ,  B01J8/02 ,  B01J19/00 ,  C07C67/54

CPC classification number: C07C67/03 ,  B01D3/009 ,  B01J8/0278 ,  B01J19/0046 ,  B01J2208/00893 ,  B01J2208/025 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01J2219/00759 ,  C07C29/34 ,  C07C67/40 ,  C07C67/54 ,  Y02P20/127 ,  Y02P20/582 ,  C07C69/14 ,  C07C31/12

Abstract: A reactive distillation method comprises introducing a feed stream to a reactive distillation column, wherein the feed stream comprises ethanol, contacting the feed stream with one or more catalysts in the reactive distillation column during a distillation, and removing butyl acetate during the distillation from the reactive distillation column as a bottoms stream. The feed stream reacts in the presence of the one or more catalysts to produce a reaction product comprising ethyl acetate, butanol, and water, wherein the butanol and the ethyl acetate react to produce a reaction product comprising the butyl acetate.

公开(公告)号：US20180264428A1

公开(公告)日：2018-09-20

申请号：US15991992

申请日：2018-05-29

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William Banyai ,  Bill James Peck ,  Andres Fernandez ,  Siyuan Chen ,  Pierre Indermuhle

IPC: B01J19/00 ,  C12N15/66 ,  C12N15/10 ,  C40B50/00 ,  C40B40/06 ,  C40B50/18 ,  C40B50/14

CPC classification number: B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00623 ,  B01J2219/00637 ,  B01J2219/00709 ,  B01J2219/00722 ,  C12N15/09 ,  C12N15/1093 ,  C12N15/1096 ,  C12N15/66 ,  C12N15/74 ,  C40B40/06 ,  C40B50/00 ,  C40B50/14 ,  C40B50/18

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

公开(公告)号：US20180200718A1

公开(公告)日：2018-07-19

申请号：US15409048

申请日：2017-01-18

Applicant: Vasiliy Abramov

Inventor： Vasiliy Abramov

IPC: B01L3/00

CPC classification number: B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00337 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00725

Abstract: A reaction cell for an automated peptide synthesizer consists of a body having adjacent first and second reaction wells for simultaneous reactions. The first reaction well is in fluid communication with the second reaction well for reagent pre-activation simultaneously with an amino acid addition for solid state peptide production.

公开(公告)号：US20180154362A1

公开(公告)日：2018-06-07

申请号：US15825689

申请日：2017-11-29

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Helen Song Baca ,  Lewis Spencer Roach

IPC: B01L3/00 ,  C12Q1/44 ,  B01F3/08 ,  B01F5/06 ,  B01F13/00 ,  C12P19/34 ,  B01J19/00 ,  G01N15/14 ,  G01N35/08 ,  B01L7/00 ,  B82Y30/00

CPC classification number: B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US09968901B2

公开(公告)日：2018-05-15

申请号：US14549411

申请日：2013-05-21

Applicant: Steven Robert Head ,  Phillip T. Ordoukhanian ,  Daniel R. Salomon

Inventor： Steven Robert Head ,  Phillip T. Ordoukhanian ,  Daniel R. Salomon

IPC: C12Q1/68 ,  C40B40/06 ,  B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/0059 ,  B01J2219/00709 ,  B01J2219/00722 ,  C12Q1/6874 ,  C40B40/06 ,  C12Q2525/161 ,  C12Q2525/191 ,  C12Q2531/125 ,  C12Q2535/122 ,  C12Q2563/143

Abstract: The present disclosure provides methods, compositions, and kits for methods that can improve techniques nucleic acid analysis, and can allow for more reliable and accurate targeted, multiplexed, high throughput sequencing. The methods, compositions, and kits can be used for sequencing target loci of nucleic acid. The methods, compositions, and kits disclosed herein can be used for assisted de novo targeted sequencing. The methods, compositions, and kits disclosed herein can also be used for library labeling for de novo sequencing and phasing.

公开(公告)号：US09950928B2

公开(公告)日：2018-04-24

申请号：US15104448

申请日：2014-12-16

Applicant: Casale SA

Inventor： Ermanno Filippi ,  Raffaele Ostuni

IPC: C01B3/02 ,  B01J7/02 ,  B01J19/00

CPC classification number: C01B3/025 ,  B01J7/02 ,  B01J19/0046 ,  B01J2219/0059 ,  B01J2219/00756 ,  C01B2203/0233 ,  C01B2203/0244 ,  C01B2203/0283 ,  C01B2203/043 ,  C01B2203/046 ,  C01B2203/048 ,  C01B2203/143

Abstract: A process and a related equipment for producing ammonia synthesis gas from a hydrocarbon-containing feedstock (20), the process comprising the steps of: primary reforming with steam (21), secondary reforming with an oxidant stream (23), and purification of the effluent of said secondary reforming, said purification comprising a step of shift conversion (13) of carbon monoxide, wherein the synthesis gas (25) produced by said secondary reforming is subject to a medium-temperature shift over a copper-based catalyst, and the global steam to carbon ratio of the process is not greater than 2.

公开(公告)号：US20180078919A1

公开(公告)日：2018-03-22

申请号：US15825311

申请日：2017-11-29

Applicant: Arkema Inc.

Inventor： Michael S. DeCourcy ,  John L. STEINBACH ,  Nicolas DUPONT ,  Roger L. ROUNDY

IPC: B01J15/00 ,  C07C51/235 ,  C07C51/25 ,  B01J8/04 ,  B01J19/00 ,  B01J19/24 ,  B01J8/06 ,  C07C51/215 ,  C07C57/04

CPC classification number: B01J8/067 ,  B01J8/0453 ,  B01J8/048 ,  B01J8/065 ,  B01J15/005 ,  B01J19/0046 ,  B01J19/242 ,  B01J2208/00221 ,  B01J2208/00849 ,  B01J2208/0092 ,  B01J2208/025 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00594 ,  B01J2219/0072 ,  B01J2219/30226 ,  B01J2219/30265 ,  B01J2219/30475 ,  C07C51/215 ,  C07C51/235 ,  C07C51/252 ,  C07C57/04

Abstract: The present disclosure relates to a single shell open interstage reactor (“SSOI”). The SSOI comprises a first reaction stage, an interstage heat exchanger, an open interstage region, and a second reaction stage. The SSOI may be configured for upflow or downflow operation. Further, the open interstage region of the SSOI may comprise a supplemental oxidant feed. When the open interstage region comprises a supplemental oxidant feed, the SSOI may further comprise a supplemental oxidant mixing assembly. Processes for producing acrylic acid through the oxidation of propylene are also disclosed.

公开(公告)号：US09856471B2

公开(公告)日：2018-01-02

申请号：US14317082

申请日：2014-06-27

Applicant: Gen9, Inc.

Inventor： Joseph Jacobson ,  George Church ,  Larry Li-Yang Chu

IPC: C12N15/10 ,  B01L3/02 ,  B01L3/00 ,  C12Q1/68 ,  C12N15/66

CPC classification number: C12N15/1093 ,  B01J2219/00378 ,  B01J2219/00389 ,  B01J2219/0052 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00608 ,  B01J2219/00659 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01L3/0268 ,  B01L3/502792 ,  B01L2400/0436 ,  B01L2400/0439 ,  C12N15/10 ,  C12N15/66 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q2525/131 ,  C12Q2521/514 ,  C12Q2565/501

Abstract: Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products.