公开(公告)号：US20060257859A1

公开(公告)日：2006-11-16

申请号：US11404770

申请日：2006-04-17

申请人： Tse-Wen Chang ,  Jim Sheu ,  Lee-Hwa Lo ,  Nien-Yi Chen ,  Young-Sun Lin

发明人： Tse-Wen Chang ,  Jim Sheu ,  Lee-Hwa Lo ,  Nien-Yi Chen ,  Young-Sun Lin

IPC分类号： C12Q1/70 ,  C40B30/06 ,  C40B50/06 ,  C12N1/18 ,  C07K16/10

CPC分类号： C07K16/1009 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2319/00

摘要： Provided is an antibody against enterovirus 71 comprising the amino acid sequence shown in SEQ ID NOS: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, or 26 or functionally active homologues thereof. Also provided are methods for obtaining the antibody comprising (a) selecting a yeast expressing such an antibody from a yeast library, (b) culturing the yeast under conditions that the antibody is expressed, and (c) recovering the antibody from the culture. Also provided is a process for producing the antibody comprising (a) culturing a host cell under conditions that the antibody is expressed, (b) recovering the antibody from the culture, wherein the host cells are transformed or transfected for expressing the antibody against enterovirus 71. Also provided are pharmaceutical compositions comprising an antibody against enterovirus 71 and a pharmaceutically acceptable carrier or diluent, wherein the antibody has an anti-virus agent or detectable label attached thereto.