公开(公告)号：US09533074B2

公开(公告)日：2017-01-03

申请号：US13993896

申请日：2011-12-02

Applicant: Jin Sook Kwon ,  Young Keun Ahn ,  Myung Ho Jeong ,  Sun Jung Song ,  Dong Lyun Cho

Inventor： Jin Sook Kwon ,  Young Keun Ahn ,  Myung Ho Jeong ,  Sun Jung Song ,  Dong Lyun Cho

IPC: A61L27/00 ,  A61L27/54 ,  A61L31/02 ,  A61L31/16

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2310/00407 ,  A61L27/54 ,  A61L31/022 ,  A61L31/088 ,  A61L2300/22 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/418 ,  A61L2300/45 ,  A61L2300/802 ,  A61L2400/18 ,  A61L2420/08

Abstract: The present invention relates to a gene delivery stent using titanium oxide thin film coating and a method for fabricating the gene delivery stent. The gene delivery stent according to the present invention may be loaded with a drug having anti-inflammatory and anti-thrombotic effects and simultaneously deliver a gene capable of inhibiting proliferation of vascular smooth muscle cells. Accordingly, late thrombosis and metal allergy may be reduced, and vascular restenosis in the stent region may be prevented, thereby making it possible to increase treatment effects of the bare metal stent.

Abstract translation: 本发明涉及使用氧化钛薄膜包衣的基因递送支架和制造基因递送支架的方法。 根据本发明的基因递送支架可以装载具有抗炎和抗血栓形成作用的药物，同时递送能够抑制血管平滑肌细胞增殖的基因。 因此，可能降低晚期血栓形成和金属过敏，并且可以防止支架区域中的血管再狭窄，从而可以增加裸金属支架的治疗效果。

公开(公告)号：US20080139668A1

公开(公告)日：2008-06-12

申请号：US11951710

申请日：2007-12-06

Applicant: Byoung Mog Kwon ,  Yeo-Pyo Yun ,  Yong Lim ,  Dong-Woon Kim ,  Jin-Sook Kwon ,  Seung-ho Lee ,  Jin-Tae Hong

Inventor： Byoung Mog Kwon ,  Yeo-Pyo Yun ,  Yong Lim ,  Dong-Woon Kim ,  Jin-Sook Kwon ,  Seung-ho Lee ,  Jin-Tae Hong

IPC: A61K31/05 ,  A61P9/00

CPC classification number: A61K31/05

Abstract: Disclosed herein is a pharmaceutical composition for the prevention and treatment of restenosis following a blood vessel injury procedure, comprising obovatol as an active ingredient.

Abstract translation: 本文公开了一种用于预防和治疗血管损伤程序后的再狭窄的药物组合物，其包含奥泊他醇作为活性成分。

公开(公告)号：US20140018908A1

公开(公告)日：2014-01-16

申请号：US13993896

申请日：2011-12-02

Applicant: Jin Sook Kwon ,  Young Keun Ahn ,  Myung Ho Jeong ,  Sun Jung Song ,  Dong Lyun Cho

Inventor： Jin Sook Kwon ,  Young Keun Ahn ,  Myung Ho Jeong ,  Sun Jung Song ,  Dong Lyun Cho

IPC: A61L27/54

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2310/00407 ,  A61L27/54 ,  A61L31/022 ,  A61L31/088 ,  A61L2300/22 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/418 ,  A61L2300/45 ,  A61L2300/802 ,  A61L2400/18 ,  A61L2420/08

Abstract: The present invention relates to a gene delivery stent using titanium oxide thin film coating and a method for fabricating the gene delivery stent. The gene delivery stent according to the present invention may be loaded with a drug having anti-inflammatory and anti-thrombotic effects and simultaneously deliver a gene capable of inhibiting proliferation of vascular smooth muscle cells. Accordingly, late thrombosis and metal allergy may be reduced, and vascular restenosis in the stent region may be prevented, thereby making it possible to increase treatment effects of the bare metal stent.

Abstract translation: 本发明涉及使用氧化钛薄膜包衣的基因递送支架和制造基因递送支架的方法。 根据本发明的基因递送支架可以装载具有抗炎和抗血栓形成作用的药物，同时递送能够抑制血管平滑肌细胞增殖的基因。 因此，可能降低晚期血栓形成和金属过敏，并且可以防止支架区域中的血管再狭窄，从而可以增加裸金属支架的治疗效果。