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公开(公告)号：US06770659B2
公开(公告)日：2004-08-03
申请号：US10228869
申请日：2002-08-26
Applicant: Yong-Moon Choi , Yong-Kil Kim , Jin-Uk Yoo , Eun-Ah Paek , Chun-Eung Park , Sung-Yong Seo , Coo-Min Chung , Joon Heo
Inventor： Yong-Moon Choi , Yong-Kil Kim , Jin-Uk Yoo , Eun-Ah Paek , Chun-Eung Park , Sung-Yong Seo , Coo-Min Chung , Joon Heo
IPC: A61K31445
CPC classification number: C07D401/06 , C07D211/32 , C07D409/06
Abstract: Provided herein are racemic or enantiomerically enriched benzoyl piperidine compounds and pharmaceutically useful salts thereof, pharmaceutical compositions comprising an effective amount of racemic or enantiomerically enriched benzoyl piperidine compounds to treat central nervous system diseases and methods of treating central nervous system diseases in a mammal, in particular psychoses and cognition disorders.
Abstract translation: 本文提供外消旋或对映异构体富集的苯甲酰哌啶化合物及其药学上可用的盐，包含有效量的外消旋或对映异构体富集的苯甲酰哌啶化合物以治疗中枢神经系统疾病的药物组合物，以及治疗哺乳动物中的中枢神经系统疾病的方法 精神病和认知障碍。
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2.发明申请PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND USE THEREOF 有权苯基哌嗪化合物，包含其的药物组合物及其用途公开(公告)号：US20090298851A1
公开(公告)日：2009-12-03
申请号：US12128999
申请日：2008-05-29
Applicant: Yonggil Kim , Kiho Lee , Nahmryune Cho , Jin Uk Yoo , Joon Heo , Choonho Ryu , Seonmin Dong , Man-Young Cha , Jong Gil Choi , Yunhee Kim , Mi Kyung Ji
Inventor： Yonggil Kim , Kiho Lee , Nahmryune Cho , Jin Uk Yoo , Joon Heo , Choonho Ryu , Seonmin Dong , Man-Young Cha , Jong Gil Choi , Yunhee Kim , Mi Kyung Ji
IPC: A61K31/495 , C07D241/04 , A61P25/00
CPC classification number: C07D295/088 , C07D295/096
Abstract: The present invention relates to a novel piperazine derivative or pharmaceutically acceptable salt thereof, a process for preparing the same, a pharmaceutical composition for treating central nervous system diseases comprising an effective amount of the piperazine compound and a method of treating central nervous system (CNS) disorder such as psychosis in a mammal.
Abstract translation: 本发明涉及一种新的哌嗪衍生物或其药学上可接受的盐，其制备方法，用于治疗中枢神经系统疾病的药物组合物，其包含有效量的哌嗪化合物和治疗中枢神经系统（CNS）的方法， 疾病如精神病在哺乳动物中。
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3.发明授权Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof 有权苯基哌嗪化合物，包含它们的药物组合物及其用途公开(公告)号：US07964605B2
公开(公告)日：2011-06-21
申请号：US12128999
申请日：2008-05-29
Applicant: Yonggil Kim , Kiho Lee , Nahmryune Cho , Jin Uk Yoo , Joon Heo , Choonho Ryu , Seonmin Dong , Man-Young Cha , Jong Gil Choi , Yunhee Kim , Mi Kyung Ji
Inventor： Yonggil Kim , Kiho Lee , Nahmryune Cho , Jin Uk Yoo , Joon Heo , Choonho Ryu , Seonmin Dong , Man-Young Cha , Jong Gil Choi , Yunhee Kim , Mi Kyung Ji
IPC: A61K31/4965 , C07D241/04 , C07D295/00
CPC classification number: C07D295/088 , C07D295/096
Abstract: The present invention relates to a novel piperazine derivative or pharmaceutically acceptable salt thereof, a process for preparing the same, a pharmaceutical composition for treating central nervous system diseases comprising an effective amount of the piperazine compound and a method of treating central nervous system (CNS) disorder such as psychosis in a mammal.
Abstract translation: 本发明涉及一种新的哌嗪衍生物或其药学上可接受的盐，其制备方法，用于治疗中枢神经系统疾病的药物组合物，其包含有效量的哌嗪化合物和治疗中枢神经系统（CNS）的方法， 疾病如精神病在哺乳动物中。
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