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    5α-androstane (alkyl)-3β, 5, 6β-triol injection and preparation method therefor
    2.
    发明授权
    5α-androstane (alkyl)-3β, 5, 6β-triol injection and preparation method therefor 有权
    5α-雄甾烷（烷基）-3＆bgr; 5,6和三烯注射剂及其制备方法

    公开(公告)号：US09161985B2

    公开(公告)日：2015-10-20

    申请号：US13821849

    申请日：2011-07-08

    申请人： Guangmei Yan ,  Halyan Hu ,  Jingxia Zhang ,  Pengxin Qiu ,  Ling Li ,  Ning Tian

    发明人： Guangmei Yan ,  Halyan Hu ,  Jingxia Zhang ,  Pengxin Qiu ,  Ling Li ,  Ning Tian

    IPC分类号： A61K31/56 ,  A61K47/40 ,  A61K9/00 ,  A61K31/565 ,  A61K47/48 ,  B82Y5/00 ,  A61K31/568

    CPC分类号： A61K47/40 ,  A61K9/0019 ,  A61K31/565 ,  A61K31/568 ,  A61K47/6951 ,  B82Y5/00

    摘要： A 5α-androstane-3β,5,6β-triol injection and its preparation are disclosed. The injection uses hydroxypropyl-β-cyclodextrin as a solubilizing agent and the active ingredient is present at a weight ratio of 1-20:40-500 to the hydroxypropyl-β-cyclodextrin. The injection may also comprise, by weight, 1-100 parts of at least one isotonic adjusting agent, 0-200 parts of at least one freeze drying filler, and 0-2000 parts of at least one solvent. The preparation method comprises dissolving hydroxypropyl-β-cyclodextrin solution, 5α-androstane-3β,5,6β-triol and at least one additional soluble excipient in water for injection in sequence to obtain a raw injection solution, and subjecting the raw injection solution to decolorization, depyrogenation, filtration and sterilization to obtain the injection, Drying the filtrate yields a solid for injection.

    摘要翻译： 公开了5α-雄甾烷-3＆bgr，5,6和三烯注射剂及其制备。 注射剂使用羟丙基 - 环糊精作为增溶剂，活性成分以1-20:40-500的重量比与羟丙基-β-环糊精一起存在。 注射剂还可以包含1-100份至少一种等渗调节剂，0-200份至少一种冷冻干燥填料和0-2000份至少一种溶剂。 该制备方法包括将羟丙基 - 环糊精溶液，5α-雄甾烷-3β，5,6α-三醇和至少一种额外的可溶性赋形剂在水中依次溶解，得到原始注射液， 注射溶液进行脱色，去热原，过滤和灭菌获得注射，干燥滤液得到固体用于注射。

    CRYSTALLINE FORMS OF 5alpha-ANDROSTANE-3beta,5,6beta-TRIOL AND PREPARATION METHODS THEREFOR
    3.
    发明申请
    CRYSTALLINE FORMS OF 5alpha-ANDROSTANE-3beta,5,6beta-TRIOL AND PREPARATION METHODS THEREFOR 有权
    5α-安息香酸-3β，5,6β-三醇的结晶形式及其制备方法

    公开(公告)号：US20150045566A1

    公开(公告)日：2015-02-12

    申请号：US14383405

    申请日：2012-04-11

    申请人： Suizhen Lin ,  Jingxia Zhang ,  Xinhua Li

    发明人： Suizhen Lin ,  Jingxia Zhang ,  Xinhua Li

    IPC分类号： C07J1/00

    CPC分类号： C07J1/0007 ,  C07B2200/13

    摘要： The present invention relates to four crystalline forms (crystalline forms A, B, C and D) of 5α-androstane-3β,5,6β-triol (YC-6) and preparation methods therefor. The four crystalline forms have significant difference in their lattice parameters, 2θ values and intensity in X-ray power diffraction, and melting points, etc. The study on its polymorphism is very important for further studying its effect, bioavailability and stability.

    摘要翻译： 本发明涉及5α-雄甾烷-3β，5,6α-三醇（YC-6）的四种结晶形式（晶型A，B，C和D）及其制备方法。 四种结晶形式在晶格参数方面有显着差异，2＆ X射线衍射和熔点等方面的价值和强度。其多态性研究对于进一步研究其影响，生物利用度和稳定性非常重要。

    5α-androstane-3β,5,6β-triol injection and preparation method therefor
    4.
    发明授权
    5α-androstane-3β,5,6β-triol injection and preparation method therefor 有权
    5α-雄甾烷-3和bgr，5,6和三烯注射液及其制备方法

    公开(公告)号：US09265837B1

    公开(公告)日：2016-02-23

    申请号：US14839869

    申请日：2015-08-28

    申请人： Guangmei Yan ,  Haiyan Hu ,  Jingxia Zhang ,  Pengxin Qiu ,  Ling Li ,  Ning Tian

    发明人： Guangmei Yan ,  Haiyan Hu ,  Jingxia Zhang ,  Pengxin Qiu ,  Ling Li ,  Ning Tian

    IPC分类号： A61K31/56 ,  A61K47/40 ,  A61K31/568 ,  A61K9/00

    CPC分类号： A61K47/40 ,  A61K9/0019 ,  A61K31/565 ,  A61K31/568 ,  A61K47/6951 ,  B82Y5/00

    摘要： A 5α-androstane-3β,5,6β-triol injection and its preparation are disclosed. The injection uses hydroxypropyl-β-cyclodextrin as a solubilizing agent and the active ingredient is present at a weight ratio of 1-20:40-500 to the hydroxypropyl-β-cyclodextrin. The injection may also comprise, by weight, 1-100 parts of at least one isotonic adjusting agent, 0-200 parts of at least one freeze drying filler, and 0-2000 parts of at least one solvent. The preparation method comprises dissolving hydroxypropyl-β-cyclodextrin solution, 5α-androstane-3β,5,6β-triol and at least one additional soluble excipient in water for injection in sequence to obtain a raw injection solution, and subjecting the raw injection solution to decolorization, depyrogenation, filtration and sterilization to obtain the injection. Drying the filtrate yields a solid for injection.

    摘要翻译： 公开了5α-雄甾烷-3＆bgr，5,6和三烯注射剂及其制备。 注射剂使用羟丙基 - 环糊精作为增溶剂，活性成分以1-20:40-500的重量比与羟丙基-β-环糊精一起存在。 注射剂还可以包含1-100份至少一种等渗调节剂，0-200份至少一种冷冻干燥填料和0-2000份至少一种溶剂。 该制备方法包括将羟丙基 - 环糊精溶液，5α-雄甾烷-3β，5,6α-三醇和至少一种额外的可溶性赋形剂在水中依次溶解，得到原始注射液， 注射溶液脱色，去热原，过滤和灭菌获得注射。 干燥滤液得到固体，用于注射。

    5a-Androstane-3ß,5,6ß-Triol Injection and Preparation Method Theref48
    6.
    发明申请
    5a-Androstane-3ß,5,6ß-Triol Injection and Preparation Method Theref48 审中-公开
    5α-雄甾烷-3β，5,6β-三醇注射液及其制备方法

    公开(公告)号：US20160051685A1

    公开(公告)日：2016-02-25

    申请号：US14839869

    申请日：2015-08-28

    申请人： Guangmei Yan ,  Haiyan HU ,  Jingxia ZHANG ,  Pengxin QIU ,  Ling LI ,  Ning TIAN

    发明人： Guangmei Yan ,  Haiyan HU ,  Jingxia ZHANG ,  Pengxin QIU ,  Ling LI ,  Ning TIAN

    IPC分类号： A61K47/40 ,  A61K9/00 ,  A61K31/568

    CPC分类号： A61K47/40 ,  A61K9/0019 ,  A61K31/565 ,  A61K31/568 ,  A61K47/6951 ,  B82Y5/00

    摘要： A 5α-androstane-3β,5,6β-triol injection and its preparation are disclosed. The injection uses hydroxypropyl-β-cyclodextrin as a solubilizing agent and the active ingredient is present at a weight ratio of 1-20:40-500 to the hydroxypropyl-β-cyclodextrin. The injection may also comprise, by weight, 1-100 parts of at least one isotonic adjusting agent, 0-200 parts of at least one freeze drying filler, and 0-2000 parts of at least one solvent. The preparation method comprises dissolving hydroxypropyl-β-cyclodextrin solution, 5α-androstane-3β,5,6β-triol and at least one additional soluble excipient in water for injection in sequence to obtain a raw injection solution, and subjecting the raw injection solution to decolorization, depyrogenation, filtration and sterilization to obtain the injection. Drying the filtrate yields a solid for injection.

    摘要翻译： 公开了5α-雄甾烷-3＆bgr，5,6和三烯注射剂及其制备。 注射剂使用羟丙基 - 环糊精作为增溶剂，活性成分以1-20:40-500的重量比与羟丙基-β-环糊精一起存在。 注射剂还可以包含1-100份至少一种等渗调节剂，0-200份至少一种冷冻干燥填料和0-2000份至少一种溶剂。 制备方法包括将羟丙基 - 环糊精溶液，5α-雄甾烷-3β，5,6α-三醇和至少一种额外的可溶性赋形剂在水中依次溶解，得到原始注射液， 注射溶液脱色，去热原，过滤和灭菌获得注射。 干燥滤液得到固体，用于注射。

    5a-ANDROSTANE (ALKYL)-3b, 5, 6b-TRIOL INJECTION AND PREPARATION METHOD THEREFOR
    8.
    发明申请
    5a-ANDROSTANE (ALKYL)-3b, 5, 6b-TRIOL INJECTION AND PREPARATION METHOD THEREFOR 有权
    5-ANDROSTANE（ALKYL）-3b，5，6b-TRIOL注射及其制备方法

    公开(公告)号：US20130172307A1

    公开(公告)日：2013-07-04

    申请号：US13821849

    申请日：2011-07-08

    申请人： Guangmei Yan ,  Halyan Hu ,  Jingxia Zhang ,  Pengxin Qiu ,  Ling Li ,  Ning Tian

    发明人： Guangmei Yan ,  Halyan Hu ,  Jingxia Zhang ,  Pengxin Qiu ,  Ling Li ,  Ning Tian

    IPC分类号： A61K47/40 ,  A61K31/568

    CPC分类号： A61K47/40 ,  A61K9/0019 ,  A61K31/565 ,  A61K31/568 ,  A61K47/6951 ,  B82Y5/00

    摘要： A 5α-androstane-3β,5,6β-triol injection and its preparation are disclosed. The injection uses hydroxypropyl-β-cyclodextrin as a solubilizing agent and the active ingredient is present at a weight ratio of 1-20:40-500 to the hydroxypropyl-β-cyclodextrin. The injection may also comprise, by weight, 1-100 parts of at least one isotonic adjusting agent, 0-200 parts of at least one freeze drying filler, and 0-2000 parts of at least one solvent. The preparation method comprises dissolving hydroxypropyl-β-cyclodextrin solution, 5α-androstane-3β,5,6β-triol and at least one additional soluble excipient in water for injection in sequence to obtain a raw injection solution, and subjecting the raw injection solution to decolorization, depyrogenation, filtration and sterilization to obtain the injection, Drying the filtrate yields a solid for injection.

    摘要翻译： 公开了5α-雄甾烷-3β，5,6β-三醇注射剂及其制备方法。 注射剂使用羟丙基-β-环糊精作为增溶剂，活性成分以1-20:40-500的重量比与羟丙基-β-环糊精存在。 注射剂还可以包含1-100份至少一种等渗调节剂，0-200份至少一种冷冻干燥填料和0-2000份至少一种溶剂。 制备方法包括将羟丙基-β-环糊精溶液，5α-雄甾烷-3Beta，5,6-三醇和至少一种额外的可溶性赋形剂按顺序溶解在水中以获得原始注射溶液，并将原始注射溶液 脱色，去热原，过滤和灭菌获得注射，干燥滤液得到固体用于注射。