公开(公告)号：US06365748B1

公开(公告)日：2002-04-02

申请号：US09744000

申请日：2001-01-18

申请人： Joël Radisson

发明人： Joël Radisson

IPC分类号： C07D41712

CPC分类号： C07D417/12

摘要： A method for preparing the potassium dihydrate salt of 2-[[4-(2-chlorophenyl)-2-thiazolyl]carbamoyl]indole-1-acetic acid, by reacting 2-[[4-(2-chlorophenyl)-2-thiazolyl]carbamoyl]indole-1-acetic acid or its C1-C4 alkyl esters with potassium carbonate in a two phase solvent system comprising a mixture of water and an organic solvent which is only slightly miscible with water and optionally recrystallising the precipitated intermediate solvate from water and to the potassium dihydrate salt thus obtained.

摘要翻译： 2 - [[4-（2-氯苯基）-2-噻唑基]氨基甲酰基]吲哚-1-乙酸二水合盐酸盐的制备方法， 噻唑基]氨基甲酰基]吲哚-1-乙酸或其C1-C4烷基酯与碳酸钾在两相溶剂体系中的混合物，其包含水和仅与水轻微混溶的有机溶剂的混合物，并任选地将沉淀的中间体溶剂化物从 水和由此获得的二水合二水合盐。

公开(公告)号：US06242607B1

公开(公告)日：2001-06-05

申请号：US09437362

申请日：1999-11-10

申请人： Philippe Camus ,  Marcel Descamps ,  Joël Radisson

发明人： Philippe Camus ,  Marcel Descamps ,  Joël Radisson

IPC分类号： C07D2404

CPC分类号： C07D401/04 ,  C07D211/88 ,  C07D409/04

摘要： The invention relates to glutarimides of formula (I): in which Ar represents a phenyl non substituted or substituted one or more times with one of the substituents selected from a halogen atom, a hydroxyl, a (C1-C4)alkoxy, a trifluoromethyl, a (C1-C4)alkyl, said substituents being identical or different; a pyridyl group; a thienyl group and X is methylene or ethylene, their salts and their enantiomers, as well as their method of preparation and their use for the preparation of the corresponding 3,3-disubstituted piperidines.

摘要翻译： 本发明涉及式（I）的戊二酰亚胺：其中Ar表示未取代或取代一个或多个选自卤原子，羟基，（C 1 -C 4）烷氧基，三氟甲基， （C 1 -C 4）烷基，所述取代基相同或不同; 吡啶基; 噻吩基，X是亚甲基或亚乙基，它们的盐及其对映异构体，以及它们的制备方法及其用于制备相应的3,3-二取代的哌啶的用途。