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公开(公告)号:US5318781A
公开(公告)日:1994-06-07
申请号:US43419
申请日:1993-04-06
申请人: Navnit Shah , Joel Unowsky
发明人: Navnit Shah , Joel Unowsky
IPC分类号: A61K9/48 , A61K9/66 , A61K31/545
CPC分类号: A61K31/545 , A61K9/4858 , A61K9/4891 , Y10S514/946
摘要: The oral absorption of antibiotics given of administration is significantly enhanced by use of the antibiotic in conjunction with a two-component absorption enhancing system made up of Laureth-12 together with a second component salts of capric acid and caprylic acids. The antibiotic containing two component enhancer system includes Miglyol-812 for optimum absorption.
摘要翻译: 通过使用抗生素与由Laureth-12组成的双组分吸收增强系统以及癸酸和辛酸的第二组分盐组合,使得给予给药的抗生素的口服吸收显着增强。 含有双组分增强剂系统的抗生素包括Miglyol-812以获得最佳吸收。
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公开(公告)号:US4760059A
公开(公告)日:1988-07-26
申请号:US762248
申请日:1985-08-05
申请人: Charanjit Behl , Joel Unowsky
发明人: Charanjit Behl , Joel Unowsky
IPC分类号: A61K45/08 , A61K9/02 , A61K31/395 , A61K31/41 , A61K31/43 , A61K31/435 , A61K31/535 , A61K31/545 , A61K47/00 , A61K47/28 , A61P31/04
CPC分类号: A61K9/02 , A61K31/43 , A61K31/545 , A61K47/28 , Y10S424/15 , Y10S514/965 , Y10S514/966 , Y10S514/97
摘要: The rectal absorption of the beta-lactam antibiotic ceftriaxone in a solid dosage form is enhanced with chenodeoxycholic acid or its sodium salt, in the presence of a carrier consisting of a mixture of two or more glycerides of C.sub.12 to C.sub.18 fatty acids.
摘要翻译: 在由C12- C18脂肪酸的两种或多种甘油酯的混合物组成的载体存在下,鹅脱氧胆酸或其钠盐可增强固体剂型中β-内酰胺抗生素头孢曲松的直肠吸收。
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公开(公告)号:US5190748A
公开(公告)日:1993-03-02
申请号:US809244
申请日:1991-12-18
CPC分类号: A61K47/14 , A61K47/10 , A61K47/12 , A61K9/4858 , Y10S514/946 , Y10S514/947
摘要: The absorption of antibiotics given through oral and rectal routes of administration is significantly enhanced by use of the antibiotic in conjunction with a two-component absorption enhancing system made up of an ether of a C.sub.6 to C.sub.18 alcohol and a polyoxyethylene glycol together with a second component selected from among polyoxyethylene glycol C.sub.6 to C.sub.18 glyceride esters, C.sub.6 to C.sub.18 carboxylic acids or salts thereof, and esters of two or more C.sub.6 to C.sub.18 carboxylic acids, glycerol and a polyoxyethylene glycol. A carrier and adjuvants are usually included. These compositions can be administered in any convenient oral or rectal dosage form, including tablets, capsules, beadlets and suppositories.
摘要翻译: 通过口服和直肠给药途径给予的抗生素的吸收通过使用抗生素与由C6至C18醇的醚和聚氧乙烯二醇组合的双组分吸收增强系统与第二组分一起使用而显着增强 选自聚氧乙烯二醇C6至C18甘油酯,C6至C18羧酸或其盐,以及两种或多种C6至C18羧酸的酯,甘油和聚氧乙烯二醇。 通常包括载体和佐剂。 这些组合物可以以任何方便的口服或直肠剂型施用,包括片剂,胶囊,珠粒和栓剂。
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公开(公告)号:US4525339A
公开(公告)日:1985-06-25
申请号:US434452
申请日:1982-10-15
申请人: Charanjit Behl , George Beskid , Navnit Shah , Jacques Tossounian , Joel Unowsky
发明人: Charanjit Behl , George Beskid , Navnit Shah , Jacques Tossounian , Joel Unowsky
IPC分类号: C07D477/00 , A61K9/36 , A61K9/48 , A61K9/62 , A61K31/397 , A61K31/40 , A61K31/43 , A61K31/535 , A61K31/545 , A61K47/14 , A61K47/26 , C07D499/46 , C07D499/64 , C07D499/68 , C07D499/893 , C07D499/897
CPC分类号: A61K47/14 , A61K31/40 , A61K31/43 , A61K31/545 , A61K9/4891
摘要: There is presented a method, in the form of a dosage formulation, for transforming substantially orally inactive .beta.-lactam antibiotics or their pharmaceutically acceptable salts or the esters, ethers, or hydrates of said antibiotics or their salts into orally active compounds by combination of the chosen .beta.-lactam antibiotic with an enhancer comprising an aliphatic, preferably a C.sub.2 to C.sub.18, straight- or branched-chain, saturated or unsaturated, fatty acid or an aliphatic, preferably a C.sub.2 to C.sub.12, straight- or branched-chain, saturated or unsaturated, fatty acid mono-, di- or triglyceride or mixtures thereof, partial or total esters of propylene glycol, polyethylene glycol and carbohydrates of C.sub.2 to C.sub.12 fatty acids, as well as the pharmaceutically acceptable esters and ethers of said glycerides. The antibiotic and enhancer mixture may be administered orally as a solid dosage form with the .beta.-lactam antibiotic above or, optionally, with the enhancer protected by an enteric coating.
摘要翻译: 呈现剂型制剂形式的方法,用于将基本上口服无活性的β-内酰胺抗生素或其药学上可接受的盐或所述抗生素或其盐的酯,醚或水合物转化为口服活性化合物,通过 选择的具有增强剂的β-内酰胺抗生素,其包含脂族,优选C2至C18直链或支链饱和或不饱和脂肪酸或脂族,优选C2至C12直链或支链饱和或 不饱和脂肪酸单 - ,二 - 或甘油三酸酯或其混合物,丙二醇,聚乙二醇和C2至C12脂肪酸的碳水化合物的部分或全部酯,以及所述甘油酯的药学上可接受的酯和醚。 抗生素和增强剂混合物可以作为固体剂型口服施用,其中β-内酰胺抗生素在上面,或任选地与由肠溶衣保护的增强剂一起使用。
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