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    New piperazine and piperidine compounds
    2.
    发明申请
    New piperazine and piperidine compounds 有权
    新的哌嗪和哌啶化合物

    公开(公告)号：US20060089366A1

    公开(公告)日：2006-04-27

    申请号：US11129465

    申请日：2005-05-16

    申请人： Roelof Feenstra ,  Johannes van der Heijden ,  Cornelis Kruse ,  Stephen Long ,  Gustaaf van Scharrenburg

    发明人： Roelof Feenstra ,  Johannes van der Heijden ,  Cornelis Kruse ,  Stephen Long ,  Gustaaf van Scharrenburg

    IPC分类号： A61K31/496 ,  A61K31/454 ,  C07D413/02 ,  C07D417/02

    CPC分类号： C07D263/58 ,  C07D413/12

    摘要： The invention relates to a group of novel piperazine and piperidine derivatives of the formula wherein Y is hydrogen, halogen, alkyl (1-3C), or CN, CF3, OCF3, SCF3, alkoxy(1-3C), amino or mono- or dialkyl(1-3C) substituted amino or hydroxy, X is O, S, SO or SO2, ---Z represents -C, =C or -N, R1 and R2 independently represent hydrogen or alkyl (1-3C), Q is benzyl or 2-, 3- or 4-pyridylmethyl, wich groups may be substited with one or more more substituents from the group halogen, nitro, cyano, amino, mono- or di (1-3C)alkylamino, (1-3C) alkoxy, CF3, OCF3, SCF3, (1-4C)-alkyl, (1-3C)alkylsulfonyl or hydroxy, and salts and prodrugs thereof. It has been found that these compounds have interesting pharmacological properties due to a combination of (partial) agonism towards the members of the dopamine D2-receptor subfamily and affinity for relevant serotonin and/or noradrenergic receptors.

    摘要翻译： 本发明涉及下式的一组新的哌嗪和哌啶衍生物其中Y是氢，卤素，烷基（1-3C）或CN，CF 3，OCF 3， >，SCF 3，烷氧基（1-3C），氨基或单或二烷基（1-3C）取代的氨基或羟基，X是O，S，SO或SO 2， Z代表-C，= C或-N，R 1和R 2独立地代表氢或烷基（1-3C），Q是苄基 或2-，3-或4-吡啶基甲基，其可以被一个或多个取代基取代为卤素，硝基，氰基，氨基，单或二（1-3C）烷基氨基，（1-3C）烷氧基 ，CF 3 3，OCF 3，SCF 3，（1-4C） - 烷基，（1-3C）烷基磺酰基或羟基，和盐 及其前体药物。 已经发现，这些化合物由于（多）向多巴胺D 2受体亚家族的成员的组合以及对相关的5-羟色胺和/或去甲肾上腺素能受体的亲和力而具有令人感兴趣的药理学性质。

    Vapor releasing device
    3.
    发明授权
    Vapor releasing device 失效
    蒸气释放装置

    公开(公告)号：US5000383A

    公开(公告)日：1991-03-19

    申请号：US490874

    申请日：1990-03-09

    申请人： Johannes van der Heijden

    发明人： Johannes van der Heijden

    IPC分类号： A01N25/00 ,  A01M1/20 ,  A61L9/12 ,  B65D83/00 ,  B65D85/00

    CPC分类号： A01M1/2044 ,  A61L9/12 ,  Y10S261/88

    摘要： An air freshening device having an openable outer housing that, when open, activates the air freshening device by pulling an emanator out of a fluid reservoir and, when closed, seals the fluid reservoir from either evaporation or leakage. The activation and deactivation are accomplished by the use of a hooking pin within the upper housing which engages the emanator portion and pulls the wicking stem of the emanator out of the fluid reservoir. An air channel is exposed in the open position and closed off in the closed position.

    摘要翻译： 一种空气清新装置，其具有可打开的外壳，当打开时，通过将流出器拉出流体储存器来启动空气清新装置，并且当关闭时，密封流体储存器免于蒸发或泄漏。 激活和去激活通过使用上壳体内的钩销来实现，其接合发射器部分并将发射器的芯吸杆拉出流体储存器。 空气通道暴露在打开位置，并在关闭位置关闭。

    New phenylpiperazines
    7.
    发明申请
    New phenylpiperazines 有权
    新的苯基哌嗪

    公开(公告)号：US20060293313A1

    公开(公告)日：2006-12-28

    申请号：US11450323

    申请日：2006-06-12

    申请人： Roelof Hes ,  Johannes Van der Heijden ,  Cornelis Kruse ,  Tipker Jacobus ,  Martinus Tulp ,  Gerben Visser ,  Bernard Van Vliet

    发明人： Roelof Hes ,  Johannes Van der Heijden ,  Cornelis Kruse ,  Tipker Jacobus ,  Martinus Tulp ,  Gerben Visser ,  Bernard Van Vliet

    IPC分类号： A61K31/5415 ,  A61K31/538 ,  A61K31/496 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14

    CPC分类号： C07D401/12 ,  C07D209/34 ,  C07D209/40 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

    摘要： The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as anxiety disorders, depression, Parkinson's disease, and schizophrenia. The invention relates to a group of novel phenylpiperazine derivatives of the formula (I): wherein: X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text, m has the value 2 to 6; n has the value 0-2; R5 and R6 are independently H or alkyl (1-3C); or R5+R6 represent a group —(CH2)—p wherein p has the value 3-5, and R7 is alkyl (1-3C), alkoxy (1-3C), halogen or cyano; or R6+R7 (R7 at position 7 of the indole group) represent a group —(CH2)q wherein q has the value 2-4, and salts thereof.

    摘要翻译： 本发明涉及具有令人感兴趣的药理学性质的新一组苯基哌嗪，例如对多巴胺D 2 O受体和/或5-羟色胺再摄取位点的高亲和力，以及治疗与 多巴胺能和/或血清素能系统如焦虑障碍，抑郁症，帕金森病和精神分裂症。 本发明涉及一组新的式（I）的苯基哌嗪衍生物：其中：X是本文定义的式1,2,3,4,5,6或7的基团，m的值为2 至6; n的值为0-2; R 5和R 6独立地是H或烷基（1-3C）; 或R 5 + R 6表示基团 - （CH 2）2 - ，其中p的值为3 -5和R 7是烷基（1-3C），烷氧基（1-3C），卤素或氰基; 或吲哚基的第7位上的R 6（R 7）表示 - （CH 2）2 - 其中q具有2-4，及其盐。

    Glade overcap for tilt valve
    9.
    发明授权
    Glade overcap for tilt valve 失效
    倾斜阀的玻璃罩

    公开(公告)号：US4068782A

    公开(公告)日：1978-01-17

    申请号：US653331

    申请日：1976-01-29

    申请人： Johannes Van der Heijden

    发明人： Johannes Van der Heijden

    IPC分类号： B65D83/16 ,  B65D83/14

    CPC分类号： B65D83/206 ,  B65D83/46

    摘要： A valve actuating device for use with pressurized aerosol containers of the type having tilt actuatable valves. The device includes an actuator-overcap which defines an access opening for a tiltable valve stem and has a main portion adjacent the container and a finger-depressible tab portion hinged at one end to the main portion and having its other end adjacent the stem such that the stem is tilted thereby when the tab is depressed in a direction along the stem axis. In certain preferred embodiments, the valve stem includes a spray member and the access opening is defined within the tab portion.