公开(公告)号：US20060293313A1

公开(公告)日：2006-12-28

申请号：US11450323

申请日：2006-06-12

申请人： Roelof Hes ,  Johannes Van der Heijden ,  Cornelis Kruse ,  Tipker Jacobus ,  Martinus Tulp ,  Gerben Visser ,  Bernard Van Vliet

发明人： Roelof Hes ,  Johannes Van der Heijden ,  Cornelis Kruse ,  Tipker Jacobus ,  Martinus Tulp ,  Gerben Visser ,  Bernard Van Vliet

IPC分类号： A61K31/5415 ,  A61K31/538 ,  A61K31/496 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14

CPC分类号： C07D401/12 ,  C07D209/34 ,  C07D209/40 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as anxiety disorders, depression, Parkinson's disease, and schizophrenia. The invention relates to a group of novel phenylpiperazine derivatives of the formula (I): wherein: X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text, m has the value 2 to 6; n has the value 0-2; R5 and R6 are independently H or alkyl (1-3C); or R5+R6 represent a group —(CH2)—p wherein p has the value 3-5, and R7 is alkyl (1-3C), alkoxy (1-3C), halogen or cyano; or R6+R7 (R7 at position 7 of the indole group) represent a group —(CH2)q wherein q has the value 2-4, and salts thereof.

摘要翻译： 本发明涉及具有令人感兴趣的药理学性质的新一组苯基哌嗪，例如对多巴胺D 2 O受体和/或5-羟色胺再摄取位点的高亲和力，以及治疗与 多巴胺能和/或血清素能系统如焦虑障碍，抑郁症，帕金森病和精神分裂症。 本发明涉及一组新的式（I）的苯基哌嗪衍生物：其中：X是本文定义的式1,2,3,4,5,6或7的基团，m的值为2 至6; n的值为0-2; R 5和R 6独立地是H或烷基（1-3C）; 或R 5 + R 6表示基团 - （CH 2）2 - ，其中p的值为3 -5和R 7是烷基（1-3C），烷氧基（1-3C），卤素或氰基; 或吲哚基的第7位上的R 6（R 7）表示 - （CH 2）2 - 其中q具有2-4，及其盐。

公开(公告)号：US20050227405A1

公开(公告)日：2005-10-13

申请号：US10514347

申请日：2003-05-19

申请人： Ernst Jan Sudholter ,  Alexander Sieval ,  Han Zuilhof ,  Louis Cornelia De Smet ,  Gerben Visser ,  Wouter Olthuis ,  Piet Bergveld ,  E.J. Faber

发明人： Ernst Jan Sudholter ,  Alexander Sieval ,  Han Zuilhof ,  Louis Cornelia De Smet ,  Gerben Visser ,  Wouter Olthuis ,  Piet Bergveld ,  E.J. Faber

IPC分类号： G01N27/414 ,  H01L29/78 ,  H01L51/40 ,  H01L21/00 ,  H01L21/336

CPC分类号： G01N27/414

摘要： The invention relates to a method for producing a hybrid organic silicon field effect transistor structure, comprising the steps of: i) providing a group IV element based semiconductor substrate provided with a source region, gate region and drain region, having at least in the gate region a surface with hydrogen terminated group IV elements; and ii) covering at least the gate region with an organic monolayer by covalently reacting monolayer forming molecules with terminated hydrogen of the group IV elements at the surface, which monolayer forming molecules comprise a proximal terminated hydrogen reactive group and a spacer group and to a hybrid organic silicon field effect transistor structure as obtainable with the method.

摘要翻译： 本发明涉及一种用于制造混合有机硅场效应晶体管结构的方法，包括以下步骤：i）提供具有至少在栅极中的源极区，栅极区和漏极区的基于IV族元素的半导体衬底 区域具有氢端基IV族元素的表面; 和ii）通过使单层形成分子与表面上的IV族元素的终止氢共价反应，至少覆盖具有有机单层的栅区，所述单层形成分子包含近端封端的氢反应性基团和间隔基团，并且与混合物 有机硅场效应晶体管结构可用该方法获得。