公开(公告)号：US07776867B2

公开(公告)日：2010-08-17

申请号：US11169312

申请日：2005-06-29

申请人： John Laird Buchanan ,  William H. Buckner ,  Simon A. Burkitt ,  Erin F. DiMauro ,  Christopher N. Farthing ,  Alexander D. Frenkel ,  Martin J. Harrison ,  Frank Kayser ,  Jinqian Liu ,  Sarah E. Lively ,  Teresa L. Marshall ,  David C. McGowan ,  Rajiv Sharma ,  Stephen J. Shuttleworth ,  Xiaotian Zhu

发明人： John Laird Buchanan ,  William H. Buckner ,  Simon A. Burkitt ,  Erin F. DiMauro ,  Christopher N. Farthing ,  Alexander D. Frenkel ,  Martin J. Harrison ,  Frank Kayser ,  Jinqian Liu ,  Sarah E. Lively ,  Teresa L. Marshall ,  David C. McGowan ,  Rajiv Sharma ,  Stephen J. Shuttleworth ,  Xiaotian Zhu

IPC分类号： C07D495/04 ,  C07D243/08 ,  C07D519/00 ,  A61K31/519 ,  A61K31/4995 ,  A61K31/496 ,  A61K31/427 ,  A61K31/5513 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61P35/00

CPC分类号： C07D491/04 ,  C07D495/04

摘要： The present invention relates to furanopyrimidine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula I.

摘要翻译： 本发明涉及具有通式I的呋喃并嘧啶化合物及其立体异构体，互变异构体，溶剂合物，药用盐和衍生物及其前药。 本发明还包括药物组合物，其包含式I化合物，治疗哺乳动物各种疾病和病症的方法，包括炎症，抑制T细胞活化，增殖，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风， 多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球性肾炎，过敏性疾病，哮喘，干草病，湿疹， 结肠癌和胸腺瘤，包括向哺乳动物施用治疗有效量的式I化合物。本发明还涉及制备药物的方法，其包含一种或多种式I化合物。