公开(公告)号：US20060068002A1

公开(公告)日：2006-03-30

申请号：US11281191

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060073201A1

公开(公告)日：2006-04-06

申请号：US11280712

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060068017A1

公开(公告)日：2006-03-30

申请号：US11280121

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/14

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060068001A1

公开(公告)日：2006-03-30

申请号：US11280908

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060067999A1

公开(公告)日：2006-03-30

申请号：US11280382

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060062843A1

公开(公告)日：2006-03-23

申请号：US11274984

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/28 ,  A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060068018A1

公开(公告)日：2006-03-30

申请号：US11280124

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/14

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.