公开(公告)号：US20060068002A1

公开(公告)日：2006-03-30

申请号：US11281191

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060073201A1

公开(公告)日：2006-04-06

申请号：US11280712

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060068017A1

公开(公告)日：2006-03-30

申请号：US11280121

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/14

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060068001A1

公开(公告)日：2006-03-30

申请号：US11280908

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060067999A1

公开(公告)日：2006-03-30

申请号：US11280382

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060062843A1

公开(公告)日：2006-03-23

申请号：US11274984

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/28 ,  A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060068018A1

公开(公告)日：2006-03-30

申请号：US11280124

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/14

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060068000A1

公开(公告)日：2006-03-30

申请号：US11280485

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Larner ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Larner ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20210177076A1

公开(公告)日：2021-06-17

申请号：US16710852

申请日：2019-12-11

申请人： John Clark ,  Steven White

发明人： John Clark ,  Steven White

IPC分类号： A41D27/10

摘要： Cuff frames and garments with cuff frames configured to receive an arm, a wrist, and a hand of a wearer. The cuff frames include a wall extending along and radially spaced from a longitudinal axis. The wall defines a wrist portion, a hand portion, and an arm portion. The wrist portion is radially spaced from the longitudinal axis at a first distance to define a wrist opening. The hand portion is longitudinally adjacent to the wrist portion and flares outwards from the wrist portion. The arm portion is longitudinally adjacent to the wrist portion opposite the hand portion and flares outwards from the wrist portion. The first distance is selected to enable the hand and the wrist of the wearer to pass through the wrist opening.

公开(公告)号：US20210177077A1

公开(公告)日：2021-06-17

申请号：US16710920

申请日：2019-12-11

申请人： John Clark ,  Steven White

发明人： John Clark ,  Steven White

IPC分类号： A41D27/10

摘要： Garments including a sleeve and a cuff frame. The sleeve including a cuff and defining a sleeve opening configured to receive an arm, a wrist, and a hand of a wearer. The cuff frame being secured to the sleeve proximate the cuff and configured to support the sleeve opening from collapsing under compressive forces. The cuff frame defines a wrist opening sized to enable the hand and the wrist of the wearer to pass through the wrist opening.