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1.发明申请公开(公告)号：US20090325862A1
公开(公告)日：2009-12-31
申请号：US12227055
申请日：2007-04-30
Applicant: Christian Steinkuhler , Gretchen Bain , John Trauger
Inventor： Christian Steinkuhler , Gretchen Bain , John Trauger
CPC classification number: G01N33/573 , A61K31/19 , G01N33/6896 , G01N2333/4703 , G01N2500/04
Abstract: The instant invention is directed to methods for treating neurodegenerative diseases comprises administering an effective amount of a selective histone deacetylase 8 inhibitor to a patient in need thereof.
Abstract translation: 本发明涉及治疗神经变性疾病的方法，包括向有需要的患者施用有效量的选择性组蛋白脱乙酰酶8抑制剂。
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公开(公告)号：US09512222B2
公开(公告)日：2016-12-06
申请号：US14307515
申请日：2014-06-18
Applicant: Kurt Alex Heldwein , Igor Splawski , Jennifer Brogdon , Joshua Goldstein , William Dole , John Trauger , Chonghui Zhang
Inventor： Kurt Alex Heldwein , Igor Splawski , Jennifer Brogdon , Joshua Goldstein , William Dole , John Trauger , Chonghui Zhang
IPC: C07K16/28 , A61K39/395 , C07K14/47 , A61P9/10 , A61K39/00
CPC classification number: C07K16/28 , A61K9/0019 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , C07K14/4726 , C07K16/2851 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes referred to as “LOX-1”), and pharmaceutical compositions and methods of treatment comprising the same.
Abstract translation: 本发明涉及与人凝集素样氧化的低密度脂蛋白（LDL）（低密度脂蛋白）受体1（以下有时称为“LOX-1”）结合的单克隆抗体，以及包含该受体的药物组合物和治疗方法。
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公开(公告)号：US20170260272A1
公开(公告)日：2017-09-14
申请号：US15390067
申请日：2016-12-23
Applicant: Kurt Alex HELDWEIN , Jennifer BROGDON , William DOLE , John TRAUGER , Yuting TANG , Julia NEUGEBAUER , Annika SCHMID
Inventor： Kurt Alex HELDWEIN , Jennifer BROGDON , William DOLE , John TRAUGER , Yuting TANG , Julia NEUGEBAUER , Annika SCHMID
IPC: C07K16/28
CPC classification number: C07K16/2851 , A61K39/3955 , A61K2039/505 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , C07K14/33 , C07K14/4726 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes referred to as “LOX-1”), and pharmaceutical compositions and methods of treatment comprising the same.
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公开(公告)号：US20160145326A1
公开(公告)日：2016-05-26
申请号：US14819680
申请日：2015-08-06
Applicant: John Trauger , Andrei Igorevich Voznesensky
Inventor： John Trauger , Andrei Igorevich Voznesensky
IPC: C07K16/18
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to monoclonal antibodies binding to human angiopoietin-like 4 protein (hereinafter, sometimes referred to as “ANGPTL4”), and pharmaceutical compositions and methods of treatment comprising the same.
Abstract translation: 本发明涉及与人类血管生成素样蛋白质（以下有时称为“ANGPTL4”）结合的单克隆抗体，以及包含其的药物组合物和治疗方法。
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5.发明申请公开(公告)号：US20150004168A1
公开(公告)日：2015-01-01
申请号：US14307515
申请日：2014-06-18
Applicant: Kurt Alex HELDWEIN , Igor SPLAWSKI , Jennifer BROGDON , Joshua GOLDSTEIN , William DOLE , John TRAUGER , Chonghui ZHANG
Inventor： Kurt Alex HELDWEIN , Igor SPLAWSKI , Jennifer BROGDON , Joshua GOLDSTEIN , William DOLE , John TRAUGER , Chonghui ZHANG
IPC: C07K16/28
CPC classification number: C07K16/28 , A61K9/0019 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , C07K14/4726 , C07K16/2851 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes referred to as “LOX-1”), and pharmaceutical compositions and methods of treatment comprising the same.
Abstract translation: 本发明涉及与人凝集素样氧化的低密度脂蛋白（LDL）（低密度脂蛋白）受体1（以下有时称为“LOX-1”）结合的单克隆抗体，以及包含该受体的药物组合物和治疗方法。
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Patent Agency Ranking
公开(公告)号：US09988443B2
公开(公告)日：2018-06-05
申请号：US14819700
申请日：2015-08-06
Applicant: John Trauger , Andrei Igorevich Voznesensky , Julia Neugebauer , Steffen Runz
Inventor： John Trauger , Andrei Igorevich Voznesensky , Julia Neugebauer , Steffen Runz
CPC classification number: C07K16/18 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to monoclonal antibodies binding to human angiopoetin-like protein 4 (hereinafter, sometimes referred to as “ANGPTL4”), and pharmaceutical compositions and methods of treatment comprising the same.
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7.发明申请公开(公告)号：US20140377281A1
公开(公告)日：2014-12-25
申请号：US14307519
申请日：2014-06-18
Applicant: Kurt Alex HELDWEIN , Jennifer BROGDON , William DOLE , John TRAUGER , Yuting TANG , Julia NEUGEBAUER , Annika SCHMID
Inventor： Kurt Alex HELDWEIN , Jennifer BROGDON , William DOLE , John TRAUGER , Yuting TANG , Julia NEUGEBAUER , Annika SCHMID
IPC: C07K16/28
CPC classification number: C07K16/2851 , A61K39/3955 , A61K2039/505 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , C07K14/33 , C07K14/4726 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes referred to as “LOX-1”), and pharmaceutical compositions and methods of treatment comprising the same.
Abstract translation: 本发明涉及与人凝集素样氧化的低密度脂蛋白（LDL）（低密度脂蛋白）受体1（以下有时称为“LOX-1”）结合的单克隆抗体，以及包含该受体的药物组合物和治疗方法。
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公开(公告)号：US09771417B2
公开(公告)日：2017-09-26
申请号：US14819680
申请日：2015-08-06
Applicant: John Trauger , Andrei Igorevich Voznesensky
Inventor： John Trauger , Andrei Igorevich Voznesensky
IPC: A61K39/395 , C07K16/18 , C07K16/22 , A61K39/00
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to monoclonal antibodies binding to human angiopoietin-like 4 protein (hereinafter, sometimes referred to as “ANGPTL4”), and pharmaceutical compositions and methods of treatment comprising the same.
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公开(公告)号：US09562101B2
公开(公告)日：2017-02-07
申请号：US14307519
申请日：2014-06-18
Applicant: Kurt Alex Heldwein , Jennifer Brogdon , William Dole , John Trauger , Yuting Tang , Julia Neugebauer , Annika Schmid
Inventor： Kurt Alex Heldwein , Jennifer Brogdon , William Dole , John Trauger , Yuting Tang , Julia Neugebauer , Annika Schmid
IPC: C07K16/28 , A61K39/395 , C07K14/47 , A61P9/10
CPC classification number: C07K16/2851 , A61K39/3955 , A61K2039/505 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , C07K14/33 , C07K14/4726 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes referred to as “LOX-1”), and pharmaceutical compositions and methods of treatment comprising the same.
Abstract translation: 本发明涉及与人凝集素样氧化的低密度脂蛋白（LDL）（低密度脂蛋白）受体1（以下有时称为“LOX-1”）结合的单克隆抗体，以及包含该受体的药物组合物和治疗方法。
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10.发明申请公开(公告)号：US20160108110A1
公开(公告)日：2016-04-21
申请号：US14819700
申请日：2015-08-06
Applicant: John Trauger , Andrei Igorevich Voznesensky , Julia Neugebauer , Steffen Runz
Inventor： John Trauger , Andrei Igorevich Voznesensky , Julia Neugebauer , Steffen Runz
IPC: C07K16/18
CPC classification number: C07K16/18 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to monoclonal antibodies binding to human angiopoetin-like protein 4 (hereinafter, sometimes referred to as “ANGPTL4”), and pharmaceutical compositions and methods of treatment comprising the same.
Abstract translation: 本发明涉及与人血管生成素样蛋白4（以下有时称为“ANGPTL4”）结合的单克隆抗体，以及包含该组合物的药物组合物和治疗方法。
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