Methods for expansion of hematopoietic stem and progenitor cells
    1.
    发明授权
    Methods for expansion of hematopoietic stem and progenitor cells 有权
    扩大造血干细胞和祖细胞的方法

    公开(公告)号:US08642569B2

    公开(公告)日:2014-02-04

    申请号:US13145706

    申请日:2010-01-21

    IPC分类号: C12N15/113

    摘要: Described herein are methods and compositions for expanding hematopoietic stem and progenitor cells (HSPC) ex vivo and in vivo, and methods and compositions for transplanting HSPCs and treatment of anemia in a human subject. HSPCs are expanded in the presence of an inhibitor of serine threonine kinase 38 (STK38), wherein said inhibitor is preferably an RNAi agent.

    摘要翻译: 本文描述了用于在体内和体内扩展造血干细胞和祖细胞(HSPC)的方法和组合物,以及人类受试者移植HSPC和治疗贫血的方法和组合物。 存在丝氨酸苏氨酸激酶38抑制剂(STK38)的情况下HSPC扩增,其中所述抑制剂优选为RNAi剂。

    METHODS FOR EXPANSION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS
    2.
    发明申请
    METHODS FOR EXPANSION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS 有权
    用于扩增HEMATOPOIETIC STEM和PROGENITOR细胞的方法

    公开(公告)号:US20110305675A1

    公开(公告)日:2011-12-15

    申请号:US13145706

    申请日:2010-01-21

    摘要: Described herein are methods and compositions for expanding hematopoietic stem and progenitor cells (HSPC) ex vivo and in vivo, and methods and compositions for transplanting HSPCs and treatment of anemia in a human subject. HSPCs are expanded in the presence of an inhibitor of serine threonine kinase 38 (STK38), wherein said inhibitor is preferably an RNAi agent.

    摘要翻译: 本文描述了用于在体内和体内扩展造血干细胞和祖细胞(HSPC)的方法和组合物,以及人类受试者移植HSPC和治疗贫血的方法和组合物。 存在丝氨酸苏氨酸激酶38抑制剂(STK38)的情况下HSPC扩增,其中所述抑制剂优选为RNAi剂。

    Rotor Disk With Spoke Openings
    3.
    发明申请
    Rotor Disk With Spoke Openings 有权
    转盘与旋转开口

    公开(公告)号:US20130119819A1

    公开(公告)日:2013-05-16

    申请号:US13732551

    申请日:2013-01-02

    IPC分类号: H02K1/24

    CPC分类号: H02K19/103 H02K1/246

    摘要: A rotor disk for a rotor of a synchronous reluctance machine consists of a disk body material with high magnetic permeability. In order to improve the ability of the rotor disk to stand centrifugal and thermal loads, spokes extending in radial direction between a shaft opening and a disk periphery are provided with spoke openings. These openings extend over a wide distance both in circumferential direction and in radial direction to worsen the heat conducting properties of the spokes and to render the spokes less stiff.

    摘要翻译: 用于同步磁阻电机的转子的转子盘由具有高磁导率的盘体材料组成。 为了提高转子盘承受离心和热负荷的能力,在轴向开口和盘周边之间沿径向方向延伸的轮辐设置有轮辐孔。 这些开口在圆周方向和径向方向上都延伸很长的距离,以加强轮辐的导热性能,并使辐条变得不那么坚固。

    MASKING ARRANGEMENT FOR A GAS TURBINE ENGINE
    4.
    发明申请
    MASKING ARRANGEMENT FOR A GAS TURBINE ENGINE 审中-公开
    气体涡轮发动机的掩蔽装置

    公开(公告)号:US20100146980A1

    公开(公告)日:2010-06-17

    申请号:US12600262

    申请日:2007-05-22

    IPC分类号: F02K1/82

    CPC分类号: F02K1/825 F02K3/10 Y02T50/671

    摘要: A masking arrangement for a gas turbine engine includes a plurality of annular elements arranged overlapping one another when these are viewed in an axial direction so as to mask at least a substantial portion of any interior hot and rotating gas turbine engine part at an aft end of the gas turbine engine from rear view when the masking arrangement is applied downstream the interior part in the gas turbine engine.

    摘要翻译: 用于燃气涡轮发动机的掩蔽装置包括当沿轴向方向观察时重叠的多个环形元件,以便在至少大部分的内部热转动燃气涡轮发动机部件的至少一部分 当在燃气涡轮发动机的内部部分的下游施加掩蔽装置时,后视图的燃气涡轮发动机。

    Rotor disk with spoke openings
    5.
    发明授权
    Rotor disk with spoke openings 有权
    带轮辐孔的转子盘

    公开(公告)号:US08749109B2

    公开(公告)日:2014-06-10

    申请号:US13732551

    申请日:2013-01-02

    IPC分类号: H02K1/24 H02K19/02

    CPC分类号: H02K19/103 H02K1/246

    摘要: A rotor disk for a rotor of a synchronous reluctance machine consists of a disk body material with high magnetic permeability. In order to improve the ability of the rotor disk to stand centrifugal and thermal loads, spokes extending in radial direction between a shaft opening and a disk periphery are provided with spoke openings. These openings extend over a wide distance both in circumferential direction and in radial direction to worsen the heat conducting properties of the spokes and to render the spokes less stiff.

    摘要翻译: 用于同步磁阻电机的转子的转子盘由具有高磁导率的盘体材料组成。 为了提高转子盘承受离心和热负荷的能力,在轴向开口和盘周边之间沿径向方向延伸的轮辐设置有轮辐孔。 这些开口在圆周方向和径向方向上都延伸很长的距离,以加强轮辐的导热性能,并使辐条变得不那么坚固。

    GAS TURBINE INTERMEDIATE STRUCTURE AND A GAS TURBINE ENGINE COMPRISING THE INTERMEDIATE STRUCTURE
    6.
    发明申请
    GAS TURBINE INTERMEDIATE STRUCTURE AND A GAS TURBINE ENGINE COMPRISING THE INTERMEDIATE STRUCTURE 审中-公开
    气体涡轮机中间结构和包含中间结构的气体涡轮发动机

    公开(公告)号:US20070012046A1

    公开(公告)日:2007-01-18

    申请号:US11163172

    申请日:2005-10-07

    IPC分类号: F02C7/00

    摘要: The invention relates to a gas turbine intermediate structure (14) for being arranged between a first and a second gas turbine structure (8 and 9) in an axial direction (18) of a gas turbine (1). The intermediate structure (14) comprises an gas duct (5c) arranged for guiding a gas flow from a gas duct (5a) in the first structure (8) to a gas duct (5b) in the second structure (9). An inlet (19) of the intermediate structure gas duct (5c) is substantially displaced in a radial direction in relation to an outlet (20) of the intermediate structure gas duct (5c). At least one guide vane (28,29) is arranged in the intermediate structure gas duct (5c) for guiding the gas flow.

    摘要翻译: 本发明涉及一种用于在燃气轮机(1)的轴向(18)上布置在第一和第二燃气轮机结构(8和9)之间的燃气轮机中间结构(14)。 中间结构(14)包括设置用于将第一结构(8)中的气体管道(5a)的气流引导到第二结构(9)中的气体管道(5b)的气体管道(5c) 。 中间结构气体管道(5c)的入口(19)相对于中间结构气体管道(5c)的出口(20)在径向方向上基本上位移。 至少一个引导叶片(28,29)布置在中间结构气体导管(5c)中,用于引导气流。