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公开(公告)号：US07087626B2
公开(公告)日：2006-08-08
申请号：US10477111
申请日：2002-05-13
申请人： Douglas Wade Beight , Todd Vincent DeCollo , Alexander Glenn Godfrey , Theodore Goodson, Jr. , Hong-Yu Li , William Thomas McMillen , Shawn Christopher Miller , Jason Scott Sawyer , Edward C. R. Smith , Jonathan Michael Yingling
发明人： Douglas Wade Beight , Todd Vincent DeCollo , Alexander Glenn Godfrey , Theodore Goodson, Jr. , Hong-Yu Li , William Thomas McMillen , Shawn Christopher Miller , Jason Scott Sawyer , Edward C. R. Smith , Jonathan Michael Yingling
IPC分类号： A61K31/47 , C07D205/16 , C07D307/00 , C07D405/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S
摘要翻译： 新型吡唑衍生物化合物及其作为药剂的用途，特别是其作为TGF-β信号转导抑制剂的用途。 所公开的发明涉及结构（I）的化合物，其中（I）是四，五或六元饱和环，X是C，O或S
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公开(公告)号：US07834029B2
公开(公告)日：2010-11-16
申请号：US11782659
申请日：2007-07-25
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D487/04 , A61K31/4709
摘要： A compound according to formula II and the pharmaceutically acceptable salts thereof and the method of treating cancer in a patient in need thereof by administration of said compound.
摘要翻译： 根据式II的化合物及其药学上可接受的盐以及通过施用所述化合物在有需要的患者中治疗癌症的方法。
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公开(公告)号：US07265225B2
公开(公告)日：2007-09-04
申请号：US10531237
申请日：2003-11-10
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D487/04 , A61K31/4709
摘要： A compound according to formula II and the pharmaceutically acceptable salts thereof and the method of treating cancer in a patient in need thereof by administration of said compound.
摘要翻译： 根据式II的化合物及其药学上可接受的盐以及通过施用所述化合物在有需要的患者中治疗癌症的方法。
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公开(公告)号：US07365066B2
公开(公告)日：2008-04-29
申请号：US10524577
申请日：2003-09-16
申请人： Douglas Wade Beight , Rosanne Bonjouklian , Junkai Liao , William Thomas McMillen , Brandon Lee Parkhurst , Jason Scott Sawyer , Jonathan Michael Yingling , Jeremy Schulenburg York
发明人： Douglas Wade Beight , Rosanne Bonjouklian , Junkai Liao , William Thomas McMillen , Brandon Lee Parkhurst , Jason Scott Sawyer , Jonathan Michael Yingling , Jeremy Schulenburg York
IPC分类号： A61K31/535 , A61K31/50 , A01N43/42 , C07D471/02 , C07D413/00
CPC分类号： C07D471/04
摘要： Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.
摘要翻译： 公开了新的吡唑并吡啶衍生物化合物及其作为药剂的用途，特别是其用作TGF-β信号转导抑制剂的用途，其用于治疗受TGFβ影响的癌症和其它疾病状态。
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