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公开(公告)号：US07087626B2
公开(公告)日：2006-08-08
申请号：US10477111
申请日：2002-05-13
申请人： Douglas Wade Beight , Todd Vincent DeCollo , Alexander Glenn Godfrey , Theodore Goodson, Jr. , Hong-Yu Li , William Thomas McMillen , Shawn Christopher Miller , Jason Scott Sawyer , Edward C. R. Smith , Jonathan Michael Yingling
发明人： Douglas Wade Beight , Todd Vincent DeCollo , Alexander Glenn Godfrey , Theodore Goodson, Jr. , Hong-Yu Li , William Thomas McMillen , Shawn Christopher Miller , Jason Scott Sawyer , Edward C. R. Smith , Jonathan Michael Yingling
IPC分类号： A61K31/47 , C07D205/16 , C07D307/00 , C07D405/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S
摘要翻译： 新型吡唑衍生物化合物及其作为药剂的用途，特别是其作为TGF-β信号转导抑制剂的用途。 所公开的发明涉及结构（I）的化合物，其中（I）是四，五或六元饱和环，X是C，O或S
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公开(公告)号：US07405299B2
公开(公告)日：2008-07-29
申请号：US10535381
申请日：2003-11-24
申请人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
发明人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
IPC分类号： C07D241/36 , C07D217/00 , C07D401/00
CPC分类号： C07D487/04
摘要： The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
摘要翻译： 本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。
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公开(公告)号：US07365066B2
公开(公告)日：2008-04-29
申请号：US10524577
申请日：2003-09-16
申请人： Douglas Wade Beight , Rosanne Bonjouklian , Junkai Liao , William Thomas McMillen , Brandon Lee Parkhurst , Jason Scott Sawyer , Jonathan Michael Yingling , Jeremy Schulenburg York
发明人： Douglas Wade Beight , Rosanne Bonjouklian , Junkai Liao , William Thomas McMillen , Brandon Lee Parkhurst , Jason Scott Sawyer , Jonathan Michael Yingling , Jeremy Schulenburg York
IPC分类号： A61K31/535 , A61K31/50 , A01N43/42 , C07D471/02 , C07D413/00
CPC分类号： C07D471/04
摘要： Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.
摘要翻译： 公开了新的吡唑并吡啶衍生物化合物及其作为药剂的用途，特别是其用作TGF-β信号转导抑制剂的用途，其用于治疗受TGFβ影响的癌症和其它疾病状态。
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公开(公告)号：US06797723B1
公开(公告)日：2004-09-28
申请号：US10111544
申请日：2002-04-24
IPC分类号： A61K31415
CPC分类号： C07D207/08 , C07D207/333 , C07D231/12 , C07D233/64 , C07D249/06 , C07D261/08 , C07D275/02 , C07D277/24 , C07D285/01 , C07D285/06 , C07D285/10 , C07D285/12 , C07D307/12 , C07D307/42 , C07D333/16
摘要： The invention relates to novel heterocycle substituted diphenyl leukotriene B4 (LTB4) antagonists, to compositions containing such compounds, and to methods of using such compounds for treatment of inflammatory diseases.
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公开(公告)号：US06716855B2
公开(公告)日：2004-04-06
申请号：US10374124
申请日：2003-02-25
申请人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K3144
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：US06500851B2
公开(公告)日：2002-12-31
申请号：US10082453
申请日：2002-02-22
申请人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K31416
CPC分类号： C07D401/14 , C07D209/08 , C07D209/30 , C07D231/56 , C07D235/06 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：US07129245B2
公开(公告)日：2006-10-31
申请号：US10629817
申请日：2003-07-29
申请人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Pi{hacek over (n)}elro-Nú{hacek over (n)}ez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Pi{hacek over (n)}elro-Nú{hacek over (n)}ez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K31/506 , C07D239/04
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：US06689780B1
公开(公告)日：2004-02-10
申请号：US09857749
申请日：2001-06-08
申请人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Nuñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Nuñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： C07D40114
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14
摘要： This application relates to heteroaromatic amides (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译： 本申请涉及本文定义的杂芳族酰胺（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。
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公开(公告)号：US06417200B1
公开(公告)日：2002-07-09
申请号：US09445970
申请日：2000-05-09
申请人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Valentine Joseph Klimkowski , John Joseph Masters , David Mendel , Guy Milot , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Valentine Joseph Klimkowski , John Joseph Masters , David Mendel , Guy Milot , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K31445
CPC分类号： C07C271/66 , A61K31/00 , C07C257/18 , C07C259/18 , C07C271/64 , C07D209/44 , C07D211/60 , C07D261/20 , C07D333/38
摘要： This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：US06759414B2
公开(公告)日：2004-07-06
申请号：US10629760
申请日：2003-07-29
申请人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milet , Marta Maria Piñeiro-Nuñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milet , Marta Maria Piñeiro-Nuñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K315501
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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