公开(公告)号：US11744815B1

公开(公告)日：2023-09-05

申请号：US17663669

申请日：2022-05-17

申请人： Jongdae Lee

发明人： Jongdae Lee

IPC分类号： A61K31/198 ,  A61K31/352 ,  A61P19/02 ,  A61P35/00 ,  A61P37/06

CPC分类号： A61K31/198 ,  A61K31/352 ,  A61P19/02 ,  A61P35/00 ,  A61P37/06

摘要： The present invention relates to the technical field of disease treatment, and more specifically, it relates to a pharmaceutical composition, having arginine metabolite dimethylguanidino valeric acid (DMGV) or plant flavonoids to treat chronic inflammatory and cancers. Disclosed in the present invention are plant flavonoids including kaempferol, daidzein, and quercetin. Treated chronic inflammatory diseases include rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and cancer further including hematological cancers as well as solid tumor.

公开(公告)号：US20070004654A1

公开(公告)日：2007-01-04

申请号：US11359945

申请日：2006-02-21

申请人： Eyal Raz ,  Kyoko Katakura ,  Jongdae Lee ,  Daniel Rachmilewitz

发明人： Eyal Raz ,  Kyoko Katakura ,  Jongdae Lee ,  Daniel Rachmilewitz

IPC分类号： A61K31/7076 ,  A61K31/7072 ,  A61K31/7056 ,  A61K31/5377 ,  A61K31/4745

CPC分类号： A61K31/70 ,  A61K31/4745 ,  A61K31/5377 ,  A61K31/7056 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/7088

摘要： The present invention provides methods of treating gastrointestinal inflammation, methods of treating inflammatory bowel disease, methods of treating Crohn's Disease, and methods of treating ulcerative colitis in an individual. The methods generally involve administering an effective amount of an agent that increases the level of a Type I interferon and/or that activates a Type I interferon signaling pathway in the individual.

摘要翻译： 本发明提供治疗胃肠道炎症的方法，治疗炎症性肠病的方法，治疗克罗恩病的方法和治疗个体溃疡性结肠炎的方法。 所述方法通常包括施用有效量的增加I型干扰素水平的试剂和/或激活个体中的I型干扰素信号通路。

公开(公告)号：US07560436B2

公开(公告)日：2009-07-14

申请号：US11359945

申请日：2006-02-21

申请人： Eyal Raz ,  Kyoko Katakura ,  Jongdae Lee ,  Daniel Rachmilewitz

发明人： Eyal Raz ,  Kyoko Katakura ,  Jongdae Lee ,  Daniel Rachmilewitz

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： A61K31/70 ,  A61K31/4745 ,  A61K31/5377 ,  A61K31/7056 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/7088

摘要： The present invention provides methods of treating gastrointestinal inflammation, methods of treating inflammatory bowel disease, methods of treating Crohn's Disease, and methods of treating ulcerative colitis in an individual. The methods generally involve administering an effective amount of an agent that increases the level of a Type I interferon and/or that activates a Type I interferon signaling pathway in the individual.

摘要翻译： 本发明提供治疗胃肠道炎症的方法，治疗炎症性肠病的方法，治疗克罗恩病的方法和治疗个体溃疡性结肠炎的方法。 所述方法通常包括施用有效量的增加I型干扰素水平的试剂和/或激活个体中的I型干扰素信号通路。

公开(公告)号：US20050004144A1

公开(公告)日：2005-01-06

申请号：US10824833

申请日：2004-04-14

申请人： Dennis Carson ,  Howard Cottam ,  Jongdae Lee

发明人： Dennis Carson ,  Howard Cottam ,  Jongdae Lee

IPC分类号： A61K31/519 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D487/02 ,  C07D498/02

CPC分类号： A61K45/06 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  A61K2300/00

摘要： The present invention provides a broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal and treating diseases such as cancer and autoimmune disease. These agents include TLR-ligands and ligand analogs which induce interferon production, in combination with inhibitors of inosine monophosphate dehydrogenase (IMPDH), that further enhance the induction of interferon production.

摘要翻译： 本发明提供合成免疫刺激剂的广谱，持久且无毒的组合，其可用于激活哺乳动物的免疫系统并治疗疾病例如癌症和自身免疫性疾病。 这些药物包括TLR-配体和诱导干扰素产生的配体类似物，与肌苷一磷酸脱氢酶（IMPDH）的抑制剂组合，进一步增强干扰素产生的诱导。