公开(公告)号：US5229509A

公开(公告)日：1993-07-20

申请号：US849819

申请日：1992-03-11

申请人： Rosa M. Nieves Elvira ,  Santiago Conde Ruzafa ,  Jose R. Fernandez Lizarbe

发明人： Rosa M. Nieves Elvira ,  Santiago Conde Ruzafa ,  Jose R. Fernandez Lizarbe

IPC分类号： C07D501/04 ,  C07D501/59

CPC分类号： C07D501/59 ,  C07D501/02

摘要： The process comprises a series of stages essentially comprising the protection of the functional groups of the side chain of Ampicillin, esterification of the acid group, oxidation to sulphoxide, expansion of the thiazole ring to a thiazine ring, ozonolysis of the exomethylene cefam derivative obtained, substitution of the hydroxyl group by chlorine and de-protection of the functional groups, in which the order of some stages can be varied without affecting the final result.

摘要翻译： 该方法包括一系列阶段，主要包括保护氨苄青霉素侧链的官能团，酸基酯化，亚砜氧化，噻唑环向噻嗪环的扩展，所得到的异亚甲基头孢氨基衍生物的臭氧分解， 用氯取代羟基并除去官能团，其中可以改变一些阶段的顺序而不影响最终的结果。