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公开(公告)号:US20050170002A1
公开(公告)日:2005-08-04
申请号:US11052276
申请日:2005-02-07
申请人: James Kipp , Joseph Tak Wong , Mark Doty , Jane Werling , Christine Rebbeck , Sean Brynjelsen
发明人: James Kipp , Joseph Tak Wong , Mark Doty , Jane Werling , Christine Rebbeck , Sean Brynjelsen
IPC分类号: A61K9/10 , A61K9/14 , A61K9/16 , A61K31/495 , A61K31/496 , A61K7/32
CPC分类号: A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , A61K31/495 , A61K31/496
摘要: The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.