公开(公告)号：US20060222711A1

公开(公告)日：2006-10-05

申请号：US11425125

申请日：2006-06-19

申请人： James Kipp ,  Mark Doty ,  Christine Rebbeck ,  Sean Brynjelsen ,  Jamie Konkel

发明人： James Kipp ,  Mark Doty ,  Christine Rebbeck ,  Sean Brynjelsen ,  Jamie Konkel

IPC分类号： A61K31/573 ,  A61K31/496 ,  A61K9/14

CPC分类号： A61K8/044 ,  A61K8/02 ,  A61K9/10 ,  A61K9/145 ,  A61K9/146 ,  A61K31/12 ,  A61K31/4985 ,  A61K31/58 ,  A61K2800/92 ,  A61Q19/00

摘要： The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.

摘要翻译： 本发明公开了悬浮在冷冻水性基质中的药剂或化妆品颗粒形式的水溶性差的药剂或化妆品的稳定悬浮液的组合物及其制备方法。 该组合物长时间稳定，优选6个月或更长时间，适用于肠胃外，口服或非口服途径，如肺（吸入），眼科或局部给药。

公开(公告)号：US06221222B1

公开(公告)日：2001-04-24

申请号：US09204890

申请日：1998-12-03

申请人： James Kipp ,  Glenn Wehrmann ,  Richard Hammond ,  Christine Rebbeck

发明人： James Kipp ,  Glenn Wehrmann ,  Richard Hammond ,  Christine Rebbeck

IPC分类号： G01N2730

CPC分类号： G01N27/301

摘要： The present invention provides a reference electrode solution containing ammonium salts and phosphonium salts for the potentiometric measurement of pH and method of using the same. The use of the ammonium salts and the phosphonium salts to replace potassium chloride or sodium chloride as reference electrolytes in a standard reference electrode minimizes the formation of precipitates in sample solutions containing cation-sensitive compounds. Disruption of ion flow through the reference electrode is eliminated, and accurate pH measurements may be obtained in solutions that contain compounds having a strong affinity for hard cations.

摘要翻译： 本发明提供了含有铵盐和鏻盐的参比电极溶液，用于电位测量pH值和使用该方法。 在标准参考电极中使用铵盐和鏻盐代替氯化钾或氯化钠作为参考电解质，使含有阳离子敏感化合物的样品溶液中沉淀物的形成最小化。 消除了通过参比电极的离子流的破坏，并且可以在含有对硬质阳离子具有强亲和力的化合物的溶液中获得精确的pH值。

公开(公告)号：US20050170002A1

公开(公告)日：2005-08-04

申请号：US11052276

申请日：2005-02-07

申请人： James Kipp ,  Joseph Tak Wong ,  Mark Doty ,  Jane Werling ,  Christine Rebbeck ,  Sean Brynjelsen

发明人： James Kipp ,  Joseph Tak Wong ,  Mark Doty ,  Jane Werling ,  Christine Rebbeck ,  Sean Brynjelsen

IPC分类号： A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/495 ,  A61K31/496 ,  A61K7/32

CPC分类号： A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1688 ,  A61K31/495 ,  A61K31/496

摘要： The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.

公开(公告)号：US20050048126A1

公开(公告)日：2005-03-03

申请号：US10834541

申请日：2004-04-29

申请人： Barrett Rabinow ,  Randy White ,  Chong-Son Sun ,  Joseph Chung Wong ,  James Kipp ,  Mark Doty ,  Christine Rebbeck ,  Pavlos Papadopoulos

发明人： Barrett Rabinow ,  Randy White ,  Chong-Son Sun ,  Joseph Chung Wong ,  James Kipp ,  Mark Doty ,  Christine Rebbeck ,  Pavlos Papadopoulos

IPC分类号： A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K9/51 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4196

CPC分类号： A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1688 ,  A61K9/5015 ,  A61K9/5031 ,  A61K9/5036 ,  A61K9/5042 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5146 ,  A61K9/5192 ,  A61K31/495 ,  A61K31/496

摘要： The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron- to micron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 μm as measured by laser diffractometry.

摘要翻译： 本发明涉及抗微生物剂亚微米级微粒的组合物。 更具体地，本发明涉及一种抗微生物剂的组合物，其使得该试剂对通常被认为对该试剂具有抗性的生物有效。 该组合物包含亚微米级至微米级颗粒的含水悬浮液，其含有涂覆有选自以下的至少一种表面活性剂：离子表面活性剂，非离子表面活性剂，生物衍生的表面活性剂，以及氨基酸及其衍生物。 通过激光衍射测量，颗粒的体积加权平均粒度小于5um。

公开(公告)号：US20100086611A1

公开(公告)日：2010-04-08

申请号：US12414484

申请日：2009-03-30

申请人： Barrett Rabinow ,  Randy White ,  Chong-Son Sun ,  Joseph Chung Tak Wong ,  James E. Kipp ,  Mark J. Doty ,  Christine Rebbeck ,  Pavlos George Papadopoulos

发明人： Barrett Rabinow ,  Randy White ,  Chong-Son Sun ,  Joseph Chung Tak Wong ,  James E. Kipp ,  Mark J. Doty ,  Christine Rebbeck ,  Pavlos George Papadopoulos

IPC分类号： A61K9/14 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/4164 ,  A61K31/505 ,  A61P31/10

CPC分类号： A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1688 ,  A61K9/5015 ,  A61K9/5031 ,  A61K9/5036 ,  A61K9/5042 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5146 ,  A61K9/5192 ,  A61K31/495 ,  A61K31/496

摘要： The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron- to micron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 μm as measured by laser diffractometry.

摘要翻译： 本发明涉及抗微生物剂亚微米级微粒的组合物。 更具体地，本发明涉及一种抗微生物剂的组合物，其使得该试剂对通常被认为对该试剂具有抗性的生物有效。 该组合物包含亚微米级至微米级颗粒的含水悬浮液，其含有涂覆有选自以下的至少一种表面活性剂：离子表面活性剂，非离子表面活性剂，生物衍生的表面活性剂，以及氨基酸及其衍生物。 通过激光衍射测量，颗粒具有小于5μm的体积加权平均粒度。

公开(公告)号：US20060222710A1

公开(公告)日：2006-10-05

申请号：US11425122

申请日：2006-06-19

申请人： James Kipp ,  Mark Doty ,  Christine Rebbeck ,  Sean Brynjelsen ,  Jamie Konkel

发明人： James Kipp ,  Mark Doty ,  Christine Rebbeck ,  Sean Brynjelsen ,  Jamie Konkel

IPC分类号： A61K31/573 ,  A61K31/496 ,  A61K9/14

CPC分类号： A61K8/044 ,  A61K8/02 ,  A61K9/10 ,  A61K9/145 ,  A61K9/146 ,  A61K31/12 ,  A61K31/4985 ,  A61K31/58 ,  A61K2800/92 ,  A61Q19/00

摘要： The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.

公开(公告)号：US20050244503A1

公开(公告)日：2005-11-03

申请号：US10848765

申请日：2004-05-19

申请人： Barrett Rabinow ,  Jane Werling ,  Jamie Konkel ,  Mark Doty ,  Christine Rebbeck

发明人： Barrett Rabinow ,  Jane Werling ,  Jamie Konkel ,  Mark Doty ,  Christine Rebbeck

IPC分类号： A61K9/107 ,  A61K9/14 ,  A61K31/00 ,  A61K31/55 ,  A61K38/13

CPC分类号： A61K31/00 ,  A61K9/1075 ,  A61K9/145 ,  A61K9/146 ,  A61K31/55 ,  A61K38/13

摘要： This invention pertains to the formulation of small-particle suspensions of anticonvulsants and antidementia, particularly carbamazepine, for pharmaceutical use. This invention also pertains to the formulation of small-particle suspensions of immunosuppressive agents, particularly cyclosporin, for pharmaceutical use.

摘要翻译： 本发明涉及用于药物用途的抗惊厥药和抗痴呆（特别是卡马西平）的小颗粒悬浮液的制剂。 本发明还涉及用于药物用途的免疫抑制剂，特别是环孢菌素的小颗粒悬浮液的制剂。

公开(公告)号：US20050196416A1

公开(公告)日：2005-09-08

申请号：US11043314

申请日：2005-01-26

申请人： James Kipp ,  Mark Doty ,  Christine Rebbeck

发明人： James Kipp ,  Mark Doty ,  Christine Rebbeck

IPC分类号： A61K9/107 ,  A61K9/113 ,  A61K9/127 ,  A61K31/557 ,  A61K38/17 ,  A61K48/00

CPC分类号： A61K9/1075 ,  A61K9/113 ,  A61K31/557

摘要： The present invention relates to a dispersion of an active agent, which includes a multiphase system of an organic phase and an aqueous phase. The agent, preferably poorly water soluble, possesses surface active properties and itself serves as a dispersant or a stabilizer for the dispersion. The dispersion is suitable for pharmaceutical, veterinary, cosmetic, and agricultural applications, and is suitable for in vivo delivery, particularly by parenteral routes.

摘要翻译： 本发明涉及活性剂的分散体，其包括有机相和水相的多相体系。 优选水溶性差的试剂具有表面活性，并且其本身用作分散剂或分散体的稳定剂。 该分散体适用于药物，兽医，化妆品和农业应用，并且适合于体内递送，特别是通过肠胃外途径。