公开(公告)号：US20090004224A1

公开(公告)日：2009-01-01

申请号：US12192546

申请日：2008-08-15

申请人： Lance E. Steward ,  Jospeh Francis ,  Ester Fernandez-Salas ,  Marcella A. Gilmore ,  Shengwen Li ,  J. Oliver Dolly ,  Kei Roger Aoki

发明人： Lance E. Steward ,  Jospeh Francis ,  Ester Fernandez-Salas ,  Marcella A. Gilmore ,  Shengwen Li ,  J. Oliver Dolly ,  Kei Roger Aoki

IPC分类号： A61K39/08 ,  C07K14/00 ,  C07H21/04 ,  A61P27/02 ,  C12N15/63 ,  C12P21/00

CPC分类号： C07K14/33 ,  A61K38/00 ,  C12N9/52 ,  Y02A50/469

摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.