公开(公告)号：US20050032764A1

公开(公告)日：2005-02-10

申请号：US10879710

申请日：2004-06-30

申请人： Zoltan Tuba ,  Sandor Maho ,  Gyorgy Keseru ,  Jozsef Kozma ,  Janos Horvath ,  Gabor Balogh

发明人： Zoltan Tuba ,  Sandor Maho ,  Gyorgy Keseru ,  Jozsef Kozma ,  Janos Horvath ,  Gabor Balogh

IPC分类号： A61K31/56 ,  C07J41/00

CPC分类号： C07J41/0016 ,  A61K31/567

摘要： The invention is directed to a process of preparing substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.

摘要翻译： 本发明涉及一种制备基本上纯的d-（17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3E-和-3Z-肟的方法 异构体，以及合成异构体和纯异构体混合物的方法。 本发明还涉及基本上纯的d-（17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3E-肟和基本上纯的d-（17α）-13 - 乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3Z-肟异构体。 本发明的其它方面包括包含基本上纯的d-（17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3E-肟或基本上纯的d-（ 17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3Z-肟异构体，以及使用所述组合物处理的方法。