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公开(公告)号:US06417203B1
公开(公告)日:2002-07-09
申请号:US09662241
申请日:2000-09-14
申请人: Julian Blagg , Alan Daniel Brown , Elisabeth Colette Louise Gautier , Julian Duncan Smith , Andrew Brian McElroy
发明人: Julian Blagg , Alan Daniel Brown , Elisabeth Colette Louise Gautier , Julian Duncan Smith , Andrew Brian McElroy
IPC分类号: A61K314439
CPC分类号: C07D401/14 , C07D403/12 , C07D403/14
摘要: Compounds of formula (I): are antithrombotic agents, having utility in a variety of therapeutic areas including the prevention and/or treatment of deep vein thrombosis (DVT) after surgery, major medical illness, paralysis, malignancy, prolonged immobilisation trauma, application of lower limb plaster casts, or fractures of the lower limbs or pelvis; recurrent DVT; DVT during pregnancy when there is a previous history thereof; reocclusion following thrombolytic therapy; chronic arterial obstruction; peripheral vascular disease; acute myocardial infarction; unstable angina; atrial fibrillation; thrombotic stroke; transient ischaemic attacks; disseminated intravascular coagulation; coagulation in extra-corporeal circuits; occlusion of arterio-venous shunts and blood vessel grafts (including coronary artery by-pass grafts); and restenosis and occlusion following angioplasty.
摘要翻译: 式(I)化合物是抗血栓形成剂,可用于各种治疗领域,包括手术后预防和/或治疗深静脉血栓形成(DVT),主要医学疾病,麻痹,恶性肿瘤,长期固定创伤,应用 下肢石膏或下肢或骨盆骨折; 复发DVT; 怀孕期间DVT有先前的病史; 溶栓治疗后再闭塞; 慢性动脉阻塞; 周边血管疾病; 急性心肌梗塞; 不稳定型心绞痛; 房颤; 血栓性脑卒中 短暂性脑缺血发作; 弥散性血管内凝血; 额外体内循环中的凝血; 静脉分流和血管移植物(包括冠状动脉旁路移植物)的闭塞; 以及血管成形术后的再狭窄和闭塞。
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公开(公告)号:US07022727B2
公开(公告)日:2006-04-04
申请号:US10934903
申请日:2004-09-03
CPC分类号: B82Y5/00 , A61K31/439 , A61K31/46 , A61K31/4745 , A61K31/70 , A61K31/7076 , A61K47/6951 , C07H19/16 , A61K2300/00
摘要: The present invention relates to a crystalline form of 6-[(2,2-diphenylethyl)amino]-9-(N-ethyl-β-D-ribofuranosyluronamide)-N-(2-{N′-[1-(2-pyridyl)-4-piperidyl]ureido}ethyl)-9H-purine-2-carboxamide and to a process for the preparation of, compositions containing and the uses of such a crystalline form.
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公开(公告)号:US06180627B2
公开(公告)日:2001-01-30
申请号:US09372200
申请日:1999-08-11
申请人: Julian Blagg , Alan Daniel Brown , Elisabeth Colette Louise Gautier , Julian Duncan Smith , Andrew Brian McElroy
发明人: Julian Blagg , Alan Daniel Brown , Elisabeth Colette Louise Gautier , Julian Duncan Smith , Andrew Brian McElroy
IPC分类号: A61K315355
CPC分类号: C07D401/14 , A61K38/00 , C07D403/14 , C07K5/06139 , C07K5/06191
摘要: Compounds of formula (I): Are antithrombotic agents, having utility in a variety of therapeutic areas including the prevention and/or treatment of deep vein thrombosis (DVT) after surgery, major medical illness, paralysis, malignancy, prolonged immobilisation trauma, application of lower limb plaster casts, or fractures of the lower limbs or pelvis; recurrent DVT; DVT during pregnancy when there is a previous history thereof; reocclusion following thrombolytic therapy; chronic arterial obstruction; peripheral vascular disease; acute myocardial infarction; unstable angina; atrial fibrillation; thrombotic stroke; transient ischaemic attacks; disseminated intravascular coagulation; coagulation in extra-corporeal circuits; occlusion of aterio-venous shunts and blood vessel grafts (including coronary artery by-pass grafts); and restenosis and occlusion following angioplasty.
摘要翻译: 式(I)化合物:抗血栓形成剂,可用于各种治疗领域,包括手术后预防和/或治疗深静脉血栓形成(DVT),主要医学疾病,麻痹,恶性肿瘤,长期固定创伤,应用 下肢石膏或下肢或骨盆骨折; 复发DVT; 怀孕期间DVT有先前的病史; 溶栓治疗后再闭塞; 慢性动脉阻塞; 周边血管疾病; 急性心肌梗塞; 不稳定型心绞痛; 房颤; 血栓性脑卒中 短暂性脑缺血发作; 弥散性血管内凝血; 额外体内循环中的凝血; 静脉分流术和血管移植物(包括冠状动脉旁路移植物)的闭塞; 以及血管成形术后的再狭窄和闭塞。
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公开(公告)号:US06852746B2
公开(公告)日:2005-02-08
申请号:US10308805
申请日:2002-12-03
IPC分类号: C07H19/167 , A61K31/46 , A61K31/4745 , A61K31/70 , A61K31/7076 , A61K47/48 , A61P1/00 , A61P1/04 , A61P3/10 , A61P7/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/08 , A61P15/10 , A61P15/12 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/08 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07H19/16 , C07H19/00
CPC分类号: B82Y5/00 , A61K31/439 , A61K31/46 , A61K31/4745 , A61K31/70 , A61K31/7076 , A61K47/6951 , C07H19/16 , A61K2300/00
摘要: The present invention relates to a crystalline form of 6-[(2,2-diphenylethyl)amino]-9-(N-ethyl-β-D-ribofuranosyluronamide)-N-(2-{N′-[1-(2-pyridyl)-4-piperidyl]ureido}ethyl)-9H-purine-2-carboxamide and to a process for the preparation of, compositions containing and the uses of such a crystalline form.
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公开(公告)号:US06610711B2
公开(公告)日:2003-08-26
申请号:US09646255
申请日:2000-05-11
申请人: Richard Edward Armer , Christopher James Dutton , David Morris Gethin , Stephen Paul Gibson , Julian Duncan Smith , Ivan Tommasini
发明人: Richard Edward Armer , Christopher James Dutton , David Morris Gethin , Stephen Paul Gibson , Julian Duncan Smith , Ivan Tommasini
IPC分类号: A61K31445
CPC分类号: C07D211/26 , C07D211/28 , C07D211/94
摘要: Novel compounds having general formula (I), and pharmaceutically and veterinarily acceptable salts thereof wherein R1, R2, R3, W, Y1, Y2, X, n and y are as defined above and processes for their preparation and intermediate compounds prepared therein. The novel compounds are useful for having utility in the treatment of pruritic dermatoses including allergic dermatitis and atopy in animals and humans.
摘要翻译: 具有通式(I)的新型化合物及其药学上可通用的盐,其中R 1,R 2,R 3,W,Y 1,Y 2,X,n和y如上所定义,其制备方法和其中制备的中间体化合物。 新型化合物可用于治疗瘙痒性皮肤病,包括过敏性皮炎和动物和人类中的特应性反应。
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