公开(公告)号：US09987239B1

公开(公告)日：2018-06-05

申请号：US15458071

申请日：2017-03-14

申请人： Julio César Villamil Torres ,  Camilo Rey Ferro

发明人： Julio César Villamil Torres ,  Camilo Rey Ferro

IPC分类号： A61K31/192 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K47/32 ,  A61K47/12 ,  A61K47/34 ,  A61K47/10 ,  A61K47/18

CPC分类号： A61K31/192 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K47/06 ,  A61K47/12 ,  A61K47/22

摘要： The present invention relates to compositions and manufacturing methods of topical adapalene preparations, which include a solvent-lipid complex in order to keep the active pharmaceutical ingredient dissolved in a vehicle whose external or continuous phase is aqueous. Thus, a pleasant non-oily sensation is achieved at the moment of application, while greater retention of the active pharmaceutical ingredient is reached in targeted skin layers, thereby reducing systemic uptake in the blood.