公开(公告)号：US10676467B2

公开(公告)日：2020-06-09

申请号：US16025324

申请日：2018-07-02

Applicant: Zhude Tu ,  Adam Rosenberg ,  Hui Liu ,  Junbin Han

Inventor： Zhude Tu ,  Adam Rosenberg ,  Hui Liu ,  Junbin Han

IPC: C07D413/04 ,  C07D419/04 ,  C07D413/10 ,  C07D271/06 ,  C07B59/00 ,  C07D413/12

Abstract: Among the various aspects of the present disclosure is the provision of a compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof. Provided are imaging agents for imaging S1P1 and S1P1 associated diseases, disorders, and conditions. Also provided are therapeutic compositions and methods for the treatment of S1P1 associated diseases, disorders, and conditions.

公开(公告)号：US20190002450A1

公开(公告)日：2019-01-03

申请号：US16025324

申请日：2018-07-02

Applicant: Zhude Tu ,  Adam Rosenberg ,  Hui Liu ,  Junbin Han

Inventor： Zhude Tu ,  Adam Rosenberg ,  Hui Liu ,  Junbin Han

IPC: C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D271/06 ,  C07B59/00

CPC classification number: C07D413/04 ,  C07B59/002 ,  C07B2200/05 ,  C07D271/06 ,  C07D413/10 ,  C07D413/12

Abstract: Among the various aspects of the present disclosure is the provision of a compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof. Provided are imaging agents for imaging S1P1 and S1P1 associated diseases, disorders, and conditions. Also provided are therapeutic compositions and methods for the treatment of S1P1 associated diseases, disorders, and conditions.