公开(公告)号：US20100105928A1

公开(公告)日：2010-04-29

申请号：US12565176

申请日：2009-09-23

申请人： WonHo Yih ,  Jung-Rae Rho ,  Hyung-Seop Kim ,  HeonJoong Kang

发明人： WonHo Yih ,  Jung-Rae Rho ,  Hyung-Seop Kim ,  HeonJoong Kang

IPC分类号： C07D493/22 ,  C12N1/10

CPC分类号： C12N1/10 ,  C07D493/22 ,  C12P17/181

摘要： Provided is a method for massive culture of Dinophysis acuminata which is a marine dinoflagellate causing diarrhetic shellfish poisoning, and methods for extracting, isolating and purifying the shellfish toxin pectenotoxin-2 from the cultured Dinophysis acuminata. Particularly, Dinophysis acuminata is cultured massively in massive culture apparatus comprising polycarbonate water bath having the bottom sinking down toward the center of the bottom; acryl tube (E) containing fluorescent lamp laid long in the center of the water bath; air supplying device (B) supplying the air to the sinking center of the bottom of the water bath; and air purifying device containing one or more devices selected from the group consisting of UV lamp (C) and carbon cartridge filter (D) purifying the air supplied by the said air supplying device.

摘要翻译： 本发明提供了一种海洋鞭毛藻引起腹泻贝类中毒的海参for鱼的大规模培养方法，以及从培养的嗜D螨中提取，分离和纯化贝类毒素果胶毒素-2的方法。 特别地，在含有底部朝向底部中心下沉的聚碳酸酯水浴的大规模培养装置中大量培养Dinophysis acuminata， 含有荧光灯的丙烯酸管（E）长在水浴中心; 空气供给装置（B）将空气供给到水浴底部的下沉中心; 以及空气净化装置，其包含从由所述空气供给装置供给的空气净化的UV灯（C）和碳筒过滤器（D）中选择的一个以上的装置。

公开(公告)号：US20110218240A1

公开(公告)日：2011-09-08

申请号：US13126979

申请日：2009-10-30

申请人： Heon-Joong Kang ,  Jung-Rae Rho ,  Jeong-Ho Hong ,  Seung-Bum Park ,  Chan-Soo Shin ,  Jae-Hwan Lee ,  Jun-Young Hong ,  Eun-O Kim ,  Jeong-Ah Kim ,  Sang-Mi Oh

发明人： Heon-Joong Kang ,  Jung-Rae Rho ,  Jeong-Ho Hong ,  Seung-Bum Park ,  Chan-Soo Shin ,  Jae-Hwan Lee ,  Jun-Young Hong ,  Eun-O Kim ,  Jeong-Ah Kim ,  Sang-Mi Oh

IPC分类号： A61K31/352 ,  C07D493/10 ,  A61P19/10 ,  A61P3/04 ,  A61P1/16

CPC分类号： C07D493/10

摘要： Provided are a novel compound with a spiro chiral carbon backbone, a stereoisomer thereof, an enantiomer thereof, an in vivo hydrolysable precursor thereof, or a pharmaceutically acceptable salt thereof. The novel compound with the spiro chiral carbon backbone has excellent osteoblast differentiation activity, mast cell inhibitory activity, and fatty acid synthesis inhibitory activity in the liver. Therefore, the novel compound can be expected to play an innovative role in treatment of osteoporosis, fatty liver, and obesity.

摘要翻译： 本发明提供一种具有螺状手性碳骨架的新化合物，其立体异构体，其对映异构体，其体内可水解的前体或其药学上可接受的盐。 具有螺旋手性碳骨架的新型化合物在肝脏中具有优异的成骨细胞分化活性，肥大细胞抑制活性和脂肪酸合成抑制活性。 因此，新化合物可以预期在骨质疏松症，脂肪肝和肥胖症的治疗中发挥创新作用。

公开(公告)号：US20080102513A1

公开(公告)日：2008-05-01

申请号：US11849973

申请日：2007-09-04

申请人： Won Ho YIH ,  Hyung Seop KIM ,  Myung Gil PARK ,  Jung-rae RHO

发明人： Won Ho YIH ,  Hyung Seop KIM ,  Myung Gil PARK ,  Jung-rae RHO

IPC分类号： C12N1/10

CPC分类号： C12N1/10 ,  Y10S435/947

摘要： Disclosed are a method and a medium for cultivating the marine dinoflagellate Dinophysis acuminata. The laboratory culture of D. acuminata causing diarrhetic shellfish poisoning, whose cultivation was known difficult, has been first established, thereby contributing to a better understanding of ecophysiology, biology and toxicology of Dinophysis species, as well as the evolution of dinoflagellate plastids.

摘要翻译： 公开了用于培养海洋鞭毛藻Dinophion acuminata的方法和培养基。 首先建立了引起腹泻贝类中毒的腹泻贝类中毒的实验室培养，从而有助于更好地了解Dinophysis物种的生态生物学，生物学和毒理学，以及鞭毛藻质体的演化。

公开(公告)号：US08703813B2

公开(公告)日：2014-04-22

申请号：US13126979

申请日：2009-10-30

申请人： Heon-Joong Kang ,  Jung-Rae Rho ,  Jeong-Ho Hong ,  Seung-Bum Park ,  Chan-Soo Shin ,  Jae-Hwan Lee ,  Jun-Young Hong ,  Eun-O Kim ,  Jeong-Ah Kim ,  Sang-Mi Oh

发明人： Heon-Joong Kang ,  Jung-Rae Rho ,  Jeong-Ho Hong ,  Seung-Bum Park ,  Chan-Soo Shin ,  Jae-Hwan Lee ,  Jun-Young Hong ,  Eun-O Kim ,  Jeong-Ah Kim ,  Sang-Mi Oh

IPC分类号： C07D307/94 ,  A61K31/35

CPC分类号： C07D493/10

摘要： Provided is a compound having a spiro chiral carbon backbone, a stereoisomer thereof, an enantiomer thereof, an in vivo hydrolysable precursor thereof, or a pharmaceutically acceptable salt thereof. The compound having the spiro chiral carbon backbone has excellent osteoblast differentiation activity, mast cell inhibitory activity, and fatty acid synthesis inhibitory activity in the liver. Therefore, the compound can be expected to play an innovative role in treatment of osteoporosis, fatty liver, and obesity.

摘要翻译： 本发明提供具有螺状手性碳骨架的化合物，其立体异构体，其对映异构体，其体内可水解的前体或其药学上可接受的盐。 具有螺状手性碳骨架的化合物在肝脏中具有优异的成骨细胞分化活性，肥大细胞抑制活性和脂肪酸合成抑制活性。 因此，该化合物可以预期在骨质疏松症，脂肪肝和肥胖症的治疗中发挥创新作用。

公开(公告)号：US08247213B2

公开(公告)日：2012-08-21

申请号：US12565176

申请日：2009-09-23

申请人： WonHo Yih ,  Jung-Rae Rho ,  Hyung-Seop Kim ,  HeonJoong Kang

发明人： WonHo Yih ,  Jung-Rae Rho ,  Hyung-Seop Kim ,  HeonJoong Kang

IPC分类号： C12N1/10 ,  C07D493/22

CPC分类号： C12N1/10 ,  C07D493/22 ,  C12P17/181

摘要： Provided is a method for massive culture of Dinophysis acuminata which is a marine dinoflagellate causing diarrhetic shellfish poisoning, and methods for extracting, isolating and purifying the shellfish toxin pectenotoxin-2 from the cultured Dinophysis acuminata. Particularly, Dinophysis acuminata is cultured massively in massive culture apparatus comprising polycarbonate water bath having the bottom sinking down toward the center of the bottom; acryl tube (E) containing fluorescent lamp laid long in the center of the water bath; air supplying device (B) supplying the air to the sinking center of the bottom of the water bath; and air purifying device containing one or more devices selected from the group consisting of UV lamp (C) and carbon cartridge filter (D) purifying the air supplied by the said air supplying device.

摘要翻译： 提供了一种海洋鞭毛藻引起腹泻贝类中毒的海参for鱼的大规模培养方法，以及从培养的嗜D螨中提取，分离和纯化贝类毒素果胶毒素-2的方法。 特别地，在含有底部朝向底部中心下沉的聚碳酸酯水浴的大规模培养装置中大量培养Dinophysis acuminata， 含有荧光灯的丙烯酸管（E）长在水浴中心; 空气供给装置（B）将空气供给到水浴底部的下沉中心; 以及空气净化装置，其包含从由所述空气供给装置供给的空气净化的UV灯（C）和碳筒过滤器（D）中选择的一个以上的装置。

公开(公告)号：US08084242B2

公开(公告)日：2011-12-27

申请号：US11849973

申请日：2007-09-04

申请人： Won Ho Yih ,  Hyung Seop Kim ,  Myung Gil Park ,  Jung-rae Rho

发明人： Won Ho Yih ,  Hyung Seop Kim ,  Myung Gil Park ,  Jung-rae Rho

IPC分类号： C12N1/00 ,  C12N1/10

CPC分类号： C12N1/10 ,  Y10S435/947

摘要： Disclosed are a method and a medium for cultivating the marine dinoflagellate Dinophysis acuminata. The laboratory culture of D. acuminata causing diarrhetic shellfish poisoning, whose cultivation was known difficult, has been first established, thereby contributing to a better understanding of ecophysiology, biology and toxicology of Dinophysis species, as well as the evolution of dinoflagellate plastids.

摘要翻译： 公开了用于培养海洋鞭毛藻Dinophion acuminata的方法和培养基。 首先建立了引起腹泻贝类中毒的腹泻贝类中毒的实验室培养，从而有助于更好地了解Dinophysis物种的生态生物学，生物学和毒理学，以及鞭毛藻质体的演化。

公开(公告)号：US06383521B1

公开(公告)日：2002-05-07

申请号：US09839393

申请日：2001-04-20

申请人： Jong-Heon Shin ,  Ki-Woong Cho ,  Young-Wan Seo ,  Jung-Rae Rho ,  Hyi-Seung Lee ,  Ho-Jeong Kwon

发明人： Jong-Heon Shin ,  Ki-Woong Cho ,  Young-Wan Seo ,  Jung-Rae Rho ,  Hyi-Seung Lee ,  Ho-Jeong Kwon

IPC分类号： C07D30700

CPC分类号： C07D405/06

摘要： The present invention provides Wondonin A of general formula (I), which is extracted from a two-sponge association of phylum Porifera (sponge) and has antiangiogenic activity, and a process for preparing the same. Wondonin A has no cytotoxicity, but has an inhibitory activity against angiogenesis which is one of the crucial mechanisms of cancer cell metastasis, thus, it can be applied not only as an anticancer drug but also as a therapeutic agent of angiogenesis-associated diseases such as cardiac ischemia, rheumatoid arthritis, and diabetes mellitus.

摘要翻译： 本发明提供了通式（I）的Wondonin A，其由Porifera（海绵）的双海绵结合物提取并具有抗血管生成活性及其制备方法。 Wondonin A没有细胞毒性，但对血管生成具有抑制作用，这是癌细胞转移的关键机制之一，因此不仅可以用作抗癌药物，还可以用作血管生成相关疾病的治疗剂，例如 心脏缺血，类风湿性关节炎和糖尿病。